The neuroprotective effect of vitamin D in Parkinson's disease: association or causation DOI
Amin A. Hafiz

Nutritional Neuroscience, Journal Year: 2023, Volume and Issue: 27(8), P. 870 - 886

Published: Sept. 20, 2023

ABSTRACTParkinson's disease (PD) is a chronic neurodegenerative (NDD) due to the degeneration of dopaminergic neurons (DNs) in substantia nigra (SN). PD characterized by diverse motor symptoms such as rigidity, resting tremors, and bradykinesia, non-motor cognitive dysfunction sleep disturbances. Vitamin D (VD), VD receptor (VDR), metabolites are present brain play role maintaining development, differentiation, functions DNs. VDRs exert protective effects against neuropathology modulating functional capacity DNs neurotransmission SN. In virtue its anti-inflammatory antioxidant activities, could be effective prevention treatment PD. exerts neuroprotective effect reducing oxidative stress mitochondrial dysfunction, increasing autophagy brain-derived neurotrophic factor (BDNF). Low serum level connected with development dementia The VD-mediated augmenting interrelated safeguarding synaptic plasticity modulation neurotransmitter release. deficiency linked severity olfactory which precedes progression symptomatic However, precise remains unidentified, there conflict about whether can ameliorate or not.KEYWORDS: Parkinson's diseaseVitamin DVD receptorBDNFsubstantia nigraAutophagyOxidative stressdopaminergic AcknowledgementsNot applicable.Authors' contributionsAAH conceptualized manuscript, wrote, edited, reviewed main text approved final edition manuscript.Disclosure statementNo potential interest was reported author(s).Additional informationFundingThe author(s) no funding associated work featured this article.

Language: Английский

Sleep disorders cause Parkinson's disease or the reverse is true: Good GABA good night DOI Creative Commons
Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb,

Ali K. Albuhadily

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(3)

Published: March 1, 2024

Parkinson's disease (PD) is a progressive neurodegenerative brain due to degeneration of dopaminergic neurons (DNs) presented with motor and non-motor symptoms. PD symptoms are developed in response the disturbance diverse neurotransmitters including γ-aminobutyric acid (GABA). GABA has neuroprotective effect against neuropathology by protecting DNs substantia nigra pars compacta (SNpc). It been shown that GABAergic linked progression neurotransmission necessary pathway for normal sleep patterns, thus deregulation could be potential cause disorders PD.

Language: Английский

Citations

18
The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation DOI Open Access

Haydar M. Al‐kuraishy,

Majid S. Jabir,

Ali K. Albuhadily

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 91, P. 102084 - 102084

Published: Oct. 5, 2023

Language: Английский

Citations

32
Pathogenic Role of Fibrinogen in the Neuropathology of Multiple Sclerosis: A Tale of Sorrows and Fears DOI Creative Commons

Mubarak Alruwaili,

Hayder M. Al‐kuraishy, Αθανάσιος Αλεξίου

et al.

Neurochemical Research, Journal Year: 2023, Volume and Issue: 48(11), P. 3255 - 3269

Published: July 13, 2023

Abstract Multiple sclerosis (MS) is an autoimmune demyelinating neurodegenerative disease of the central nervous system (CNS) due to injury myelin sheath by immune cells. The clotting factor fibrinogen involved in pathogenesis MS triggering microglia and progress neuroinflammation. Fibrinogen level correlated with severity; consequently, inhibition cascade may reduce neuropathology. Thus, this review aimed clarify potential role how targeting affects Accumulation CNS occur independently or disruption blood–brain barrier (BBB) integrity MS. acts as transduction increases activation which induces progression inflammation, oxidative stress, neuronal injury. Besides, brain impairs remyelination process inhibiting differentiation oligodendrocyte precursor These findings proposed that associated neuropathology through interruption BBB integrity, induction neuroinflammation, demyelination suppressing oligodendrocytes. Therefore, and/or CD11b/CD18 receptors metformin statins might decrease In conclusion, expression pro-inflammatory effect on

Language: Английский

Citations

25
BDNF/TrkB activators in Parkinson's disease: A new therapeutic strategy DOI Creative Commons

Naif H. Ali,

Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(10)

Published: May 1, 2024

Parkinson's disease (PD) is a neurodegenerative disorder of the brain and manifested by motor non-motor symptoms because degenerative changes in dopaminergic neurons substantia nigra. PD neuropathology associated with mitochondrial dysfunction, oxidative damage apoptosis. Thus, modulation apoptosis growth factors could be novel boulevard management PD. Brain-derived neurotrophic factor (BDNF) its receptor tropomyosin kinase type B (TrkB) are chiefly involved neuropathology. BDNF promotes survival nigra enhances functional activity striatal neurons. Deficiency TrkB triggers degeneration accumulation α-Syn As well, BDNF/TrkB signalling reduced early phase Targeting specific activators may attenuate this review aimed to discuss potential role against In conclusion, decreased linked severity long-term complications. Activation

Language: Английский

Citations

15
Depression and type 2 diabetes: A causal relationship and mechanistic pathway DOI Creative Commons
Wael Y. Khawagi, Hayder M. Al‐kuraishy,

Nawar R. Hussein

et al.

Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: 26(8), P. 3031 - 3044

Published: May 27, 2024

Abstract Depression is a mood disorder that may increase risk for the development of insulin resistance (IR) and type 2 diabetes (T2D), vice versa. However, mechanistic pathway linking depression T2D not fully elucidated. The aim this narrative review, therefore, was to discuss possible link between T2D. coexistence twice as great compared occurrence either condition independently. Hyperglycaemia dyslipidaemia promote incidence by enhancing inflammation reducing brain serotonin (5‐hydroxytryptamine [5HT]). Dysregulation signalling in impairs 5HT signalling, leading depression. Furthermore, associated with hyperglycaemia poor glycaemic control. Psychological stress In conclusion, could be potential factor through induction inflammatory reactions oxidative affect neurotransmission. addition, chronic induce dysregulation hypothalamic–pituitary–adrenal axis circulating cortisol levels, which triggers IR

Language: Английский

Citations

12
Defective autophagy and autophagy activators in myasthenia gravis: a rare entity and unusual scenario DOI
Hayder M. Al‐kuraishy, Ghassan M. Sulaiman, Majid S. Jabir

et al.

Autophagy, Journal Year: 2024, Volume and Issue: 20(7), P. 1473 - 1482

Published: Feb. 12, 2024

Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction (NMJ) that results from autoantibodies against nicotinic acetylcholine receptors (nAchRs) at NMJs. These are mainly originated autoreactive B cells bind and destroy nAchRs NMJs preventing nerve impulses activating end-plates skeletal muscle. Indeed, immune dysregulation plays a crucial role in pathogenesis MG. Autoreactive increased MG due to defect central peripheral tolerance mechanisms. As well, T augmented diversion regulatory (T

Language: Английский

Citations

11
Therapeutic Potential Effect of Glycogen Synthase Kinase 3 Beta (GSK-3β) Inhibitors in Parkinson Disease: Exploring an Overlooked Avenue DOI Creative Commons
Areej Turkistani, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(9), P. 7092 - 7108

Published: Feb. 17, 2024

Abstract Parkinson’s disease (PD) is a progressive neurodegenerative of the brain due to degeneration dopaminergic neurons in substantia nigra (SN). Glycogen synthase kinase 3 beta (GSK-3β) implicated pathogenesis PD. Therefore, purpose present review was revise mechanistic role GSK-3β PD neuropathology, and how inhibitors affect neuropathology. GSK-3 conserved threonine/serine protein that intricate regulation cellular anabolic catabolic pathways by modulating glycogen synthase. Over-expression also interconnected with development different diseases. However, underlying mechanism neuropathology not fully clarified. induces triggering mitochondrial dysfunction oxidative stress SN. NF-κB NLRP3 inflammasome are activated response dysregulated leading neuronal injury. Higher expression early stages might contribute reduction neuroprotective brain-derived neurotrophic factor (BDNF). Thus, may be effective reducing inflammatory disorders which associated

Language: Английский

Citations

11
The conceivable role of prolactin hormone in Parkinson disease: The same goal but with different ways DOI

Haydar M. Al‐kuraishy,

Majid S. Jabir, Ali I. Al‐Gareeb

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 91, P. 102075 - 102075

Published: Sept. 14, 2023

Language: Английский

Citations

21
The potential role of brain renin‐angiotensin system in the neuropathology of Parkinson disease: Friend, foe or turncoat? DOI Creative Commons
Zainah Al‐Qahtani, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(12)

Published: June 1, 2024

Abstract Parkinson disease (PD) is one of the most common neurodegenerative diseases brain. Of note, brain renin‐angiotensin system (RAS) intricate in PD neuropathology through modulation oxidative stress, mitochondrial dysfunction and neuroinflammation. Therefore, RAS by angiotensin receptor blockers (ARBs) angiotensin‐converting enzyme inhibitors (ACEIs) may be effective reducing risk neuropathology. It has been shown that all components including peptides enzymes are present different areas. Brain plays a critical role regulation memory cognitive function, controlling central blood pressure. However, exaggerated implicated pathogenesis PD. Two well‐known pathways recognized including; classical pathway which mainly mediated AngII/AT1R detrimental effects. Conversely, non‐classical mostly ACE2/Ang1‐7/MASR AngII/AT2R beneficial effects against Exaggerated affects viability dopaminergic neurons. fundamental mechanism was not fully elucidated. Consequently, purpose this review to disclose mechanistic In addition, we try revise how ACEIs ARBs can developed for therapeutics

Language: Английский

Citations

7
Role of uric acid in neurodegenerative diseases, focusing on Alzheimer and Parkinson disease: A new perspective DOI Creative Commons
Mohammed Alrouji, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Neuropsychopharmacology Reports, Journal Year: 2024, Volume and Issue: 44(3), P. 639 - 649

Published: July 29, 2024

Abstract Neurodegenerative diseases (NDs) such as Alzheimer disease (AD) and Parkinson (PD) are group of affecting the central nervous system (CNS) characterized by progressive neurodegenerations cognitive impairment. Findings from different studies highlighted beneficial detrimental effects serum uric acid on development progression NDs. Therefore, this mini‐review aims to discuss The neuroprotective effect is mainly related antioxidant which alleviates oxidative stress‐induced neurodegeneration in AD PD. However, long‐term hyperuricemia prompts for Hyperuricemia associated with impairment dementia, gout increases dementia risk. In addition, can cause cerebral vascular injury a risk factor Taken together, relationship between NDs remains conflicting. Hence, preclinical clinical indicated regard.

Language: Английский

Citations

7