The Role of Exosomes in Central Immune Tolerance and Myasthenia Gravis DOI
Hanlu Zhang,

Siyuan Luan,

Fuqiang Wang

et al.

Immunological Investigations, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: Dec. 16, 2024

Background Immune homeostasis plays a crucial role in immunology andis dependent on both central and peripheral tolerance. Centraltolerance tolerance occur the thymus thesecondary lymphoid tissues, respectively. Tolerance breakdown andimmune regulation defects can lead to autoimmune disorders. In thisreview article, we aimed describe of exosomes inregulating provide summary their effectson pathogenesis, diagnosis, therapeutic potential inmyasthenia gravis (MG).

Language: Английский

The role of autophagy in Graves disease: knowns and unknowns DOI Creative Commons
Hayder M. Al‐kuraishy, Ghassan M. Sulaiman, Hamdoon A. Mohammed

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 6, 2025

Graves disease (GD), an autoimmune affects the thyroid gland, results in hyperthyroidisms and goiter. The main cause of GD is not clearly defined; however, stimulating autoantibodies for hormone receptor (TSHR) known as thyroid-stimulating immunoglobulins (TSIs) are primary proposed mechanism. TSI activation TSHRs gland excessive release hormones with subsequent development hyperthyroidism cellular process macroautophagy/autophagy implicated pathogenesis other diseases. Autophagy plays a critical role many diseases different stages same through modulation immunity inflammatory response. In addition, autophagy also thyroid-associated ophthalmopathy (TAO). However, exact well explained. Therefore, this review discusses how intricately involved regarding its protective harmful effects.

Language: Английский

Citations

2
The potential therapeutic role of berberine in treating epilepsy focusing on temporal lobe epilepsy: State of art and ongoing perspective DOI Creative Commons
Bshra A. Alsfouk, Hayder M. Al‐kuraishy,

Ali K. Albuhadily

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 221, P. 111189 - 111189

Published: Jan. 5, 2025

Epilepsy is a neurological disease characterized by unprovoked recurrent epileptic seizures. Temporal lobe epilepsy (TLE) the commonest type of focal in adults that resist to conventional anti-seizure medications (ASMs). Interestingly, ASMs do not affect epileptogenesis and progression disease. Therefore, repurposing natural products with anti-inflammatory, anti-oxidant effects such as berberine (BRB) may be logical treating refractory TLE. However, molecular mechanism BRB against development seizure mainly TLE was fully elucidated. we attempt this review discuss potential underlying

Language: Английский

Citations

1
Beyond Amyloid Plaque, Targeting α-Synuclein in Alzheimer Disease: The Battle Continues DOI
Hayder M. Al‐kuraishy, Ghassan M. Sulaiman, Hamdoon A. Mohammed

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: 105, P. 102684 - 102684

Published: Feb. 4, 2025

Language: Английский

Citations

0
Decrypting the Possible Mechanistic Role of Fenofibrate in Alzheimer's Disease and Type 2 Diabetes: The Truth and Mystery DOI Creative Commons
Mansour Alsaleem, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(5)

Published: March 1, 2025

Alzheimer's disease (AD) is a neurodegenerative caused by the progressive deposition of extracellular amyloid beta (Aβ) and intracellular neurofibrillary tangles (NFTs). Of note, metabolic disorders such as insulin resistance (IR) type 2 diabetes (T2D) are associated with development brain IR neurodegeneration. In addition, AD neuropathology linked cognitive impairment accelerate peripheral progression T2D. Therefore, there bidirectional relationship between T2D AD. It has been demonstrated that induce dysregulation peroxisome proliferator-activated receptor alpha (PPAR-α) leading to central disturbances. Hence, dysregulated PPAR-α could be shared mechanism in both T2D, restoration signalling agonist fenofibrate (FN) may alleviate this review aims shed light on potential involvement AD, how FN effective management seems dual neuroprotective antidiabetic effects can mitigate T2D-related complications modulating various cellular processes inflammatory pathways. conclusion, possible candidate different pathways involved pathogenesis these conditions.

Language: Английский

Citations

0
The neuroprotective role of Humanin in Alzheimer's disease: The molecular effects DOI Creative Commons
Saad Misfer Alqahtani, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177510 - 177510

Published: March 1, 2025

Humanin (HN) is an endogenous micropeptide also known as a mitochondria-derived peptide. It has neuroprotective effect against Alzheimer's disease (AD) and other neurodegenerative diseases by improving hippocampal acetylcholine attenuating the development of oxidative stress associated neurotoxicity. HN protects neuron from toxic effects amyloid beta (Aβ). regarded biomarker mitochondrial stress. Interestingly, aging reduces brain expression HN, leading to cognitive impairment elevating risk neurodegeneration, including AD. However, in old subjects AD patients, circulating levels increase compensatory mechanism reduce neurodegeneration dysfunction Conversely, studies demonstrated reduction These findings indicated controversial points regarding precise mechanistic role Therefore, aim this review was discuss exact neuropathology molecular mechanisms

Language: Английский

Citations

0
Insight into the Mechanistic role of Colchicine in Atherosclerosis DOI
Hayder M. Al‐kuraishy, Ghassan M. Sulaiman, Hamdoon A. Mohammed

et al.

Current Atherosclerosis Reports, Journal Year: 2025, Volume and Issue: 27(1)

Published: March 20, 2025

Language: Английский

Citations

0
Targeting of AMPK/MTOR signaling in the management of atherosclerosis: Outmost leveraging DOI
Hayder M. Al‐kuraishy, Ghassan M. Sulaiman, Mayyadah H. Mohsin

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 309, P. 142933 - 142933

Published: April 8, 2025

Language: Английский

Citations

0
To establish and validate autophagy related biomarkers for the diagnosis of IgA nephropathy DOI Creative Commons
Sijia Ma, Chao Wang, Jing Liu

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 22, 2025

Language: Английский

Citations

0
The Compelling Role of Brain‐Derived Neurotrophic Factor Signaling in Multiple Sclerosis: Role of BDNF Activators DOI Creative Commons
Hayder M. Al‐kuraishy, Ghassan M. Sulaiman, Hamdoon A. Mohammed

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(12)

Published: Dec. 1, 2024

Brain-derived neurotrophic factor (BDNF) is a neurotrophin, acting as signal and neuromodulator in the central nervous system (CNS). BDNF synthesized from its precursor proBDNF within CNS peripheral tissues. Through activation of NTRK2/TRKB (neurotrophic receptor tyrosine kinase 2), promotes neuronal survival, synaptic plasticity, growth, whereas it inhibits microglial release pro-inflammatory cytokines. dysregulated different neurodegenerative diseases depressions. However, there major controversy concerning levels stages multiple sclerosis (MS). Therefore, this review discusses potential role signaling MS, how modulators affect pathogenesis outcomes disease.

Language: Английский

Citations

2
Identification of key regulatory factors for m6A in myasthenia gravis and characteristics of the immune characteristics DOI Creative Commons

Yaoqi Wu,

Xiaoqing Cai,

Yingying Jiao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract Myasthenia gravis (MG), a rare autoimmune disorder, presents complex pathogenesis involving various immune molecules. The modification of N6-methyladenosine (m6A) regulates diverse metabolic and immunopathological processes; however, its role in MG remains unclear. We downloaded dataset GSE85452 from the GEO database to identify differentially expressed genes regulated by m6A. Random Forest (RF) method was utilized pivotal regulatory associated with m6A modification. Subsequently, prognostic model crafted confirmed using this gene set. Patients were stratified according expression levels these key genes. Additionally, MG-specific signatures delineated examining cell infiltration patterns their correlations. Further functional annotation, protein-protein interaction mapping, molecular docking analyses performed on biomarkers, leading discovery three that exhibited significant differential within dataset: RBM15, CBLL1, YTHDF1.The random forest algorithm as MG, validated constructing clinical prediction model. Based expression, we divided patients into two groups, revealing distinct varying abundances. also discovered 61 phenotype conducted an in-depth exploration biological roles. YTHDF1 found positively correlated CD56dim natural killer cells, T type 1 helper cells. These stable diagnostic m6A-related markers both validation cohorts. Our findings suggest for MG. analysis may elucidate roles microenvironment

Language: Английский

Citations

0