Ginsenoside Re Prevents Depression-like Behaviors via Inhibition of Inflammation, Oxidative Stress, and Activating BDNF/TrkB/ERK/CREB Signaling: An In Vivo and In Vitro Study
Hongyu Chen,
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Mengmeng Dong,
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Huihan He
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et al.
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(36), P. 19838 - 19851
Published: Aug. 26, 2024
Depression
is
a
widespread
disease,
with
high
mortality
and
recurrence
rates.
Recent
studies
have
shown
that
elevated
cytokine
levels
are
implicated
in
the
molecular
mechanisms
of
depression.
Oxidative
stress
contributes
to
stimulation
production.
Growing
evidence
suggests
ginsenoside
Re
(Gs-Re)
exerts
neuroprotective
effect
on
hippocampus
by
suppressing
oxidative
inflammation.
However,
mechanism
Gs-Re
treatment
depression
remain
understudied.
This
study
aimed
evaluate
antidepressant-like
effects
possible
underlying
mechanisms.
In
this
article,
was
studied
both
vitro
(H
Language: Английский
Effect of Ginseng Supplementation on Exercise Endurance as a Support for Cardiovascular Disease Management: A Systematic Review and Meta-Analysis
Angelika Szymańska,
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Anna Nowak,
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Anna Lipert
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et al.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
14(1), P. 32 - 32
Published: Dec. 29, 2024
Ginseng
has
multi-directional
pharmacological
properties.
Some
data
suggest
that
ginseng
can
enhance
physical
endurance,
which,
in
turn,
leads
to
protection
of
the
cardiovascular
system.
However,
not
all
experiments
are
conclusive.
For
this
reason,
main
aim
research
was
perform
a
meta-analysis
and
review
studies
published
between
years
2013
2023
concerning
effect
on
performance
animal
human
models.
Medline,
Pubmed,
ClinicalKey
electronic
databases
were
used
analyze
data.
The
search
strategy
included
following
criteria:
exercise;
supplementation;
supplements.
results
supplementation
may
have
positive
CK
levels
studies.
Similar
observations
stated
relation
serum
lactate
BUN.
Furthermore,
study
showed
significant
increase
exercise
time
exhaustion
VO2
max
after
supplementation.
literature
conducted
identified
endurance.
Due
fact
most
current
based
models,
further
models
is
needed
identify
effective
dosage
or
form
applied
be
supportive
element
CVD
management.
Language: Английский