Anti-inflammatory role of gold nanoparticles in the prevention and treatment of Alzheimer's disease DOI Creative Commons

Munire Aili,

Kebing Zhou,

Jun Zhan

et al.

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(36), P. 8605 - 8621

Published: Jan. 1, 2023

Alzheimer's disease (AD) is a neurodegenerative that causes memory and cognitive dysfunction reduces person's decision-making reasoning functions. AD the leading cause of dementia in elderly. Patients with have increased expression pro-inflammatory cytokines nervous system, sustained inflammatory response impairs neuronal function. Meanwhile, long-term use anti-inflammatory drugs can reduce incidence to some extent. This confirms anti-neuroinflammation may be an effective treatment for AD. Gold nanoparticles (AuNPs) are emerging nanomaterial promising physicochemical properties, antioxidant. AuNPs neuroinflammation by inducing macrophage polarization toward M2 phenotype, reducing cytokine expression, blocking leukocyte adhesion, decreasing oxidative stress. Therefore, gradually attracting interest scholars used treating diseases drug delivery. Herein, we explored role mechanism The topic worth exploring future, not only help solve global public health problem but also provide reference other neuroinflammatory diseases.

Language: Английский

Deep learning detection of nanoparticles and multiple object tracking of their dynamic evolution during in situ ETEM studies DOI Creative Commons

Khuram Faraz,

Thomas Grenier, Christophe Ducottet

et al.

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Feb. 15, 2022

In situ transmission electron microscopy (TEM) studies of dynamic events produce large quantities data especially under the form images. important case heterogeneous catalysis, environmental TEM (ETEM) gas and temperature allows to follow a population supported nanoparticles (NPs) evolving reactive conditions. Interpreting properly image sequences gives precious information on catalytic properties active phase by identifying causes for its deactivation. To perform quantitative, objective robust treatment, we propose an automatic procedure track observed in Scanning ETEM (STEM ETEM). Our approach involves deep learning computer vision developments multiple object tracking. At first, registration step corrects displacements misalignment inherent acquisition. Then, detects all frames video sequences. Finally, iterative tracking algorithm reconstructs their trajectories. This treatment deduce quantitative statistical features about evolution or motion, such as Brownian behavior merging crossing events. We treat calcination palladium (oxide) / delta-alumina, where present discussion operating processes Ostwald ripening NP aggregative coalescence.

Language: Английский

Citations

43

Flexible pressure and temperature sensors towards e-skin: material, mechanism, structure and fabrication DOI Open Access

Sheng-Rui Tian,

Yilin Wang, Haitao Deng

et al.

Soft Science, Journal Year: 2023, Volume and Issue: 3(3)

Published: Aug. 7, 2023

Electronic skin (E-skin) has gained significant attention due to its potential applications in the Internet of Things (IoT), artificial intelligence (AI), and flexible multi-sensing systems. Mimicking human skin, e-skin sensing devices can be employed various scenarios. Among most important elements for tactile sensors are pressure temperature sensors, which have increasingly garnered research interest over past few decades. However, design fabrication advanced challenging owing complications such as signal interference, complex mechanism integration, structural issues. This review provides an overview used e-skin, covering four main perspectives: material selection, design, manufacturing methods. The materials different entire system comprehensively discussed, along with single compound mechanisms sensing. Pressure divided into two types based on their electric output signals, exemplified detail. methods fabricate these including printing methods, outlined. Lastly, a summary future challenges faced by is presented.

Language: Английский

Citations

31

Efficient removal of Cr(VI) from aqueous solutions using chitosan/Na‐alginate bio‐based nanocomposite hydrogel DOI
Ghada A. Mahmoud, Asmaa Sayed, Manar El‐Sayed Abdel‐Raouf

et al.

Journal of Applied Polymer Science, Journal Year: 2023, Volume and Issue: 140(21)

Published: March 24, 2023

Abstract This research article aimed to assist the works conducted save water resources, which are rapidly depleted as a result of climate change by eliminating toxic chromium ions Cr(VI) from simulated solution. In this regard, chitosan/Na‐alginate/polyacrylic acid (CS/Na‐Alg/PAAc) and Ni/chitosan/Na‐alginate/polyacrylic (Ni@CS/Na‐Alg/PAAc) were created eco‐friendly hydrogel composites via gamma radiation. The matrix served basin for in‐situ formation Ni nanoparticles. prepared characterized FTIR XRD analyses. surface morphology nanocomposite was also verified SEM. It exhibited dense packing nanoparticles representing about 2.5% atomic percentage depicted EDX analysis. swelling performance investigated versus different pH values maximum percent attained non‐Fickian character at = 13 5 CS/Na‐Alg/PAAc Ni@CS/Na‐Alg/PAAc, respectively. Furthermore, topographies Ni@CS/Na‐Alg/PAAc loaded with examined AFM values. removal top achieved 8 (58.06 74.5 mg/g respectively) best fit Freundlich isotherm model calculated R L indicated favorable adsorption.

Language: Английский

Citations

27

Au@MOFs used as peroxidase-like catalytic nanozyme for bacterial infected wound healing through bacterial membranes disruption and protein leakage promotion DOI Creative Commons

Xiuli Ren,

Linna Chang,

Yanan Hu

et al.

Materials & Design, Journal Year: 2023, Volume and Issue: 229, P. 111890 - 111890

Published: April 1, 2023

Bacterial biofilms often hinder the healing of infected chronic wounds. Hence, it is significant to explore ways destroy bacterial biofilms. In this work, a photothermal therapy strategy designing Au clusters modified ZIF-8 MOFs (Au@ZIF-8) as peroxidase-like catalytic nanozyme was proposed for wound healing. Under near-infrared laser (NIR), prepared Au@ZIF-8 present enhanced activity and excellent response properties. achieved membrane disruption rate 66.3% MRSA clearance up 97%. also catalyzed endogenous H2O2 OH almost 97.4% in animal experiments. The with properties has great potential treatment diabetic wounds through membranes protein leakage promotion.

Language: Английский

Citations

27

Anti-inflammatory role of gold nanoparticles in the prevention and treatment of Alzheimer's disease DOI Creative Commons

Munire Aili,

Kebing Zhou,

Jun Zhan

et al.

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(36), P. 8605 - 8621

Published: Jan. 1, 2023

Alzheimer's disease (AD) is a neurodegenerative that causes memory and cognitive dysfunction reduces person's decision-making reasoning functions. AD the leading cause of dementia in elderly. Patients with have increased expression pro-inflammatory cytokines nervous system, sustained inflammatory response impairs neuronal function. Meanwhile, long-term use anti-inflammatory drugs can reduce incidence to some extent. This confirms anti-neuroinflammation may be an effective treatment for AD. Gold nanoparticles (AuNPs) are emerging nanomaterial promising physicochemical properties, antioxidant. AuNPs neuroinflammation by inducing macrophage polarization toward M2 phenotype, reducing cytokine expression, blocking leukocyte adhesion, decreasing oxidative stress. Therefore, gradually attracting interest scholars used treating diseases drug delivery. Herein, we explored role mechanism The topic worth exploring future, not only help solve global public health problem but also provide reference other neuroinflammatory diseases.

Language: Английский

Citations

27