DEVELOPMENT AND EVALUATION OF ACECLOFENAC-LOADED NANOSPONGE HYDROGEL FOR ENHANCED TOPICAL ANTI-INFLAMMATORY DELIVERY

International Journal of Applied Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 104 - 114

Published: March 7, 2025

Objective: Aceclofenac (ACE) is a derivative of phenylacetic acid and non-steroidal anti-inflammatory drug (NSAID) known for its anti-inflammatory, analgesic, antipyretic properties. This study aims to enhance ACE's solubility therapeutic efficacy by developing NanoSponges (NS) loaded into hydrogel topical delivery, addressing the limitations current ACE formulations, such as rapid metabolism short half-life. Methods: NS were synthesized using emulsion solvent diffusion technique with varying concentrations Ethyl Cellulose (EC) Poly Vinyl Alcohol (PVA). Ten formulations evaluated particle size (PS), Particle Dispersion Index (PDI), Production Yield percentage (PY%), Entrapment Efficiency (EE%). Fourier Transform Infrared Spectroscopy (FTIR) Differential Scanning Calorimetry (DSC) analyses confirmed compatibility between excipients. The surface morphology was examined Field Emission Electron Microscopy (FESEM). optimal Formulation (F2) integrated seven based on Hydroxy Propyl Methyl (HPMC). Results: F2 had PY% 77.92±2.2%, an EE% 90.05±1.1%, PS 127.3±3.2 nm, PDI 0.1±0.02. formulation (G1) showed pH 6.2±0.15, Drug Content (DC%) 95.19±0.23%, spreadability 9.5±0.2 cm, permeation rate 55.94±1.4% over 8 h. Additionally, G1 demonstrated in vivo activity 65.38±1.1% 24 h cumulative release 84.5±3.8% same period. Conclusion: NS-loaded presents promising strategy enhancing potential providing extended improved stability, effectively existing formulations.

Language: Английский

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In vitro and preclinical evaluation of the antifungal activity of 6-methoxy-1 H-indole-2-carboxylic acid produced by Bacillus toyonensis strain OQ071612 formulated as nanosponge hydrogel

Microbial Cell Factories, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 1, 2025

Abstract Background In a previous study, 6-methoxy-1 H-indole-2-carboxylic acid (MICA) was isolated from the culture broth of Bacillus toyonensis strain OQ071612 soil isolate in our laboratory, and it demonstrated promising antifungal activities. The current study designed to create nanosponge (NS)-hydrogel (HG)-containing MICA followed by vitro preclinical evaluation for potential clinical use topical treatment mycotic infections. Results enhanced NS formula created using Box Behnken Design (BBD), with independent process parameters including polyvinyl alcohol percentage (w/v%), homogenization time, speed polymer: linker ratio. Dependent were particle size (PS), polydispersity index (PDI), entrapment efficiency percent (EE%). A hydrogel formulated NS. drug release data indicated that best matched Higuchi’s kinetic model. NS-HG stable when compared fluconazole, exhibited increased antimycotic activity against C. albicans . An vivo investigation revealed MICA-NS-HG survival rates, wound gap repair, reduction, inflammation inhibition. Masson’s trichrome staining histological analyses collagen deposition improved healing. Moreover, 1.5-fold greater permeability through rat skin control, 1% isoconazole. Conclusion formulation is viable vehicle better more effective MICA. These findings represent significant advancement derived naturally occurring bacteria.

Language: Английский

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Comprehensive Narrative Review on Nanotechnology for the Treatment of Glaucoma

Asian Journal of Pharmacy and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 39 - 47

Published: March 5, 2025

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Language: Английский

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Microfluidic generation of drug-loaded polymer microcapsules with modulated core–shell morphologies and drug release profiles

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163244 - 163244

Published: May 1, 2025

Language: Английский

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Nanosponge-mediated oligonucleotide delivery: A cutting-edge technology towards cancer management

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 91, P. 105226 - 105226

Published: Dec. 3, 2023

Language: Английский

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