Journal of Molecular Modeling, Journal Year: 2024, Volume and Issue: 31(1)
Published: Dec. 5, 2024
Language: Английский
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106811 - 106811
Published: March 1, 2025
Language: Английский
Citations
1
Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(9), P. 5650 - 5669
Published: Aug. 20, 2024
Liposomes, made up of phospholipid bilayers, are efficient nanocarriers for drug delivery because they can encapsulate both hydrophilic and lipophilic drugs. Conventional cancer treatments sometimes involve considerable toxicities adverse reactions (ADRs), which limits their clinical value. Despite liposomes' promise in addressing these concerns, trials have revealed significant limitations, including stability, targeted distribution, scaling challenges. Recent focused on enhancing liposome formulations to increase therapeutic efficacy while minimizing negative effects. Notably, the approval liposomal medications like Doxil demonstrates potential treatment. However, intricacy preparation requirement comprehensive regulatory remain substantial impediments. Current trial updates show continued efforts improve targeting mechanisms, payload capacity order address issues. The future therapy depends challenges provide patients with more effective safer treatment alternatives.
Language: Английский
Citations
7
Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(5), P. 2118 - 2147
Published: April 25, 2024
The various kinds of nanocarriers (NCs) have been explored for the delivery therapeutics designed management skin manifestations. NCs are considered as one promising approaches attributable to sustained release and enhanced penetration. Despite extensive applications NCs, challenges in their via barrier (majorly stratum corneum) persisted. To overcome all associated with microneedle (MN) technology has emerged a beacon hope. Programmable drug release, being painless, its minimally invasive nature make it an intriguing strategy circumvent multiple systems. integration positive traits MNs boosts therapeutic effectiveness by evading corneum, facilitating through enhancing targeted delivery. This review discusses function skin, importance MNs, types superiority NC-loaded MNs. We highlighted NC-integrated ailments, combinational delivery, active targeting, vivo imaging, theranostics. clinical trials, patent portfolio, marketed products drug/NC-integrated covered. Finally, regulatory hurdles toward benchtop-to-bedside translation, along prospects needed scale up MN technology, deliberated. current is anticipated deliver thoughtful visions researchers, clinicians, formulation scientists successful development MN-technology-based product carefully optimizing variables.
Language: Английский
Citations
6
Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101054 - 101054
Published: April 1, 2025
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 1054 - 1054
Published: Aug. 9, 2024
The diversity of cyclodextrins and their derivatives is increasing with continuous research. In addition to monomolecular different branched chains, cyclodextrin-based polymers have emerged. aim this review summarize these innovations, a special focus on the study applications in nano-delivery systems. areas covered include nanospheres, nano-sponges, nanogels, cyclodextrin metal–organic frameworks, liposomes, emulsions, providing comprehensive in-depth understanding design development
Language: Английский
Citations
3
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 310, P. 143440 - 143440
Published: April 23, 2025
Language: Английский
Citations
0
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 24, 2025
The advancement in exclusively tailored therapeutic delivery systems has escalated a great deal of interest targeted to augment efficacy and lessen adverse effects. approach promisingly helps surmount the unmet clinical needs conventional therapies, including chemoresistance, limited penetration, side In case melanoma, various receptors were overexpressed on tumor site, among which folate receptor (FR) targeting is considered be progressive for managing melanoma. FRs are macromolecules glycosyl phosphatidylinositol-attached protein that possess globular assembly with greater affinity toward specific ligands. So, functional ligands can utilized design nanocarriers (NCs) effectively bind FRs. Hence, folate-adorned NCs (FNCs) offer benefits such as site-specific targeting, cargo protection, minimizing toxicity. This review focuses insights implications FRs, mechanisms, challenges, advantages FNCs. Further, applications FNCs, liposomes, polymeric NCs, albumin nanoparticles, inorganic liquid crystalline nanogels, have been elaborated melanoma therapy. Likewise, potential FNCs immunotherapy, photodynamic therapy, chemotherapy, gene photothermal imaging exhaustively discussed. Furthermore, translational hurdles solutions discussed detail. present expected give thoughtful ideas researchers, industry stakeholders, formulation scientists efficacious development
Language: Английский
Citations
0
Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 92, P. 105325 - 105325
Published: Dec. 30, 2023
Language: Английский
Citations
3
ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(10), P. 3216 - 3227
Published: Sept. 25, 2024
Combination therapy has been proven as an effective strategy for cancer treatment. To this end, we report herein a self-assembled nucleic acid-based complex dual photodynamic and antisense therapy. It contains nucleolin-targeting As1411-based G-quadruplex platform, partially hybridized oligonucleotide 4625, which can inhibit the antiapoptotic protein B cell lymphoma-xL inducing apoptotic death, zinc(II) phthalocyanine (ZnPc)-based photosensitizer held by noncovalent interactions. Through series of in vitro experiments, have demonstrated that DNA be internalized selectively to nucleolin-overexpressed MCF-7 A549 cells through receptor-mediated endocytosis is localized lysosomes. Upon light irradiation, photosensitization ZnPc triggers formation reactive oxygen species killing promotes lysosomal escape 4625 The combined therapeutic effect eliminate effectively with half maximal inhibitory concentration ca. 0.5 μM.
Language: Английский
Citations
0
Journal of Molecular Modeling, Journal Year: 2024, Volume and Issue: 31(1)
Published: Dec. 5, 2024
Language: Английский
Citations
0