Frontiers in Cellular and Infection Microbiology,
Journal Year:
2022,
Volume and Issue:
12
Published: March 25, 2022
Peptides
comprise
a
versatile
class
of
biomolecules
that
present
unique
chemical
space
with
diverse
physicochemical
and
structural
properties.
Some
classes
peptides
are
able
to
naturally
cross
the
biological
membranes,
such
as
cell
membrane
blood-brain
barrier
(BBB).
Cell-penetrating
(CPPs)
barrier-penetrating
(B3PPs)
have
been
explored
by
biotechnological
pharmaceutical
industries
develop
new
therapeutic
molecules
carrier
systems.
The
computational
prediction
peptides’
penetration
into
membranes
has
emerged
an
interesting
strategy
due
their
high
throughput
low-cost
screening
large
libraries.
Structure-
sequence-based
information
peptides,
well
atomistic
biophysical
models,
in
computer-assisted
discovery
strategies
classify
identify
structures
pharmacokinetic
properties
related
translocation
through
biomembranes.
Computational
predict
permeability
biomembranes
include
cheminformatic
filters,
molecular
dynamics
simulations,
artificial
intelligence
algorithms,
statistical
choice
most
adequate
method
depends
on
purposes
investigation.
Here,
we
exhibit
discuss
some
principles
applications
these
methods
widely
used
biomembranes,
exhibiting
applications.
Frontiers in Oncology,
Journal Year:
2021,
Volume and Issue:
10
Published: Feb. 2, 2021
Obesity
and
type
2
diabetes
have
both
been
associated
with
increased
cancer
risk
are
becoming
increasingly
prevalent.
Metabolic
abnormalities
such
as
insulin
resistance
dyslipidemia
obesity
implicated
in
the
obesity-cancer
relationship.
Multiple
mechanisms
proposed
to
link
progression,
including
an
increase
insulin/IGF-1
signaling,
lipid
glucose
uptake
metabolism,
alterations
profile
of
cytokines,
chemokines,
adipokines,
well
changes
adipose
tissue
directly
adjacent
sites.
This
review
aims
summarize
provide
update
on
epidemiological
mechanistic
evidence
linking
cancer,
focusing
roles
insulin,
lipids,
tissue.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
35(21)
Published: Nov. 29, 2022
Abstract
Emerging
as
a
potent
anticancer
treatment,
subcellular
targeted
cancer
therapy
has
drawn
increasing
attention,
bringing
great
opportunities
for
clinical
application.
Here,
two
targeting
strategies
four
main
organelles
(mitochondria,
lysosome,
endoplasmic
reticulum,
and
nucleus),
including
molecule‐
nanomaterial
(inorganic
nanoparticles,
micelles,
organic
polymers,
others)‐based
delivery
or
therapeutic
strategies,
are
summarized.
Phototherapy,
chemotherapy,
radiotherapy,
immunotherapy,
“all‐in‐one”
combination
among
the
covered
in
detail.
Such
materials
constructed
based
on
specific
properties
relevant
mechanisms
of
organelles,
enabling
elimination
tumors
by
inducing
dysfunction
corresponding
destroying
structures.
The
challenges
faced
organelle‐targeting
therapies
also
Looking
forward,
paradigm
with
enhanced
efficacy
compared
to
current
approaches
is
envisioned.
Cancers,
Journal Year:
2020,
Volume and Issue:
12(12), P. 3529 - 3529
Published: Nov. 26, 2020
With
improved
understanding
of
the
immunogenicity
triple-negative
breast
cancer
(TNBC),
immunotherapy
has
emerged
as
a
promising
candidate
to
treat
this
lethal
disease
owing
lack
specific
targets
and
effective
treatments.
While
immune
checkpoint
inhibition
(ICI)
been
effectively
used
in
for
several
types
solid
tumor,
monotherapies
targeting
programmed
death
1
(PD-1),
its
ligand
PD-L1,
or
cytotoxic
T
lymphocyte-associated
protein
4
(CTLA-4)
have
shown
little
efficacy
TNBC
patients.
Over
past
few
years,
various
therapeutic
candidates
reviewed,
attempting
improve
ICI
on
through
combinatorial
treatment.
In
review,
we
describe
clinical
limitations
illustrate
from
an
immunological,
pharmacological,
metabolic
perspective
that
may
potentiate
therapy
outcomes
NMR in Biomedicine,
Journal Year:
2022,
Volume and Issue:
36(6)
Published: June 1, 2022
Magnetic
resonance
(MR)
is
a
powerful
technique
for
noninvasively
probing
molecular
species
in
vivo
but
suffers
from
low
signal
sensitivity.
Saturation
transfer
(ST)
MRI
approaches,
including
chemical
exchange
saturation
(CEST)
and
conventional
magnetization
contrast
(MTC),
allow
imaging
of
low-concentration
components
with
enhanced
sensitivity
using
indirect
detection
via
the
abundant
water
proton
pool.
Several
recent
studies
have
shown
utility
relayed
nuclear
Overhauser
effect
(rNOE)
originating
nonexchangeable
carbon-bound
protons
mobile
macromolecules
solution.
In
this
review,
we
describe
mechanisms
leading
to
occurrence
rNOE-based
signals
spectrum
(Z-spectrum),
those
immobile
sources
binding.
While
it
becoming
clear
that
MTC
mainly
an
signal,
continue
use
classical
nomenclature
separate
rNOE
macromolecules,
which
will
refer
as
rNOEs.
Some
emerging
applications
rNOEs
macromolecular
solution
such
proteins
carbohydrates
or
studying
binding
small
substrates
are
discussed.
