Acta Pharmaceutica Sinica B,
Journal Year:
2022,
Volume and Issue:
12(8), P. 3427 - 3447
Published: Jan. 13, 2022
Platelets
buoy
up
cancer
metastasis
via
arresting
cells,
enhancing
their
adhesion,
and
facilitating
extravasation
through
the
vasculature.
When
deprived
of
intracellular
granular
contents,
platelet
decoys
could
prevent
metastatic
tumor
formation.
Inspired
by
these,
we
developed
nanoplatesomes
fusing
membranes
with
lipid
(P-Lipo)
to
restrain
formation
more
efficiently.
It
was
shown
nanoplateletsomes
bound
circulating
cells
(CTC)
efficiently,
interfered
CTC
arrest
vessel
endothelial
layers,
epithelial-mesenchymal
transition
as
nanodecoys.
More
importantly,
in
mouse
breast
model,
decrease
survival
blood
counteract
growth
efficiently
inhibiting
inflammation
suppressing
escape.
Therefore,
nanoplatelesomes
might
usher
a
new
avenue
suppress
lung
metastasis.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
35(3)
Published: Nov. 7, 2022
Microbiota-based
therapeutics
offer
innovative
strategies
to
treat
inflammatory
bowel
diseases
(IBDs).
However,
the
poor
clinical
outcome
so
far
and
limited
flexibility
of
bacterial
approach
call
for
improvement.
Inspired
by
health
benefits
probiotics
in
alleviating
symptoms
diseases,
bioartificial
are
designed
restore
intestinal
microenvironment
colitis
regulating
redox
balance,
immune
responses,
gut
microbiome.
The
probiotic
comprises
two
components:
an
E.
coli
Nissle
1917-derived
membrane
(EM)
as
surface
biodegradable
diselenide-bridged
mesoporous
silica
nanoparticles
(SeM)
core.
When
orally
administered,
probiotic-inspired
nanomedicine
(SeM@EM)
adheres
strongly
mucus
layer
restored
balance
regulation
homeostasis
a
murine
model
acute
induced
dextran
sodium
sulfate.
In
addition,
respective
properties
EM
SeM
synergistically
alter
microbiome
favorable
state
increasing
diversity
shifting
profile
anti-inflammatory
phenotype.
This
work
suggests
safe
effective
that
can
IBDs
therapy.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(14)
Published: Feb. 1, 2022
Both
tumor-associated
macrophages
(TAMs)
and
hypoxia
condition
severely
restrict
the
antitumor
potency
during
cancer
immunotherapy.
It
is
essential
to
overcome
two
issues
for
improving
therapeutic
efficacy.
In
this
study,
a
hollow
mesoporous
Prussian
blue
(HMPB)
nanosystem
with
mannose
decoration
hydroxychloroquine
(HCQ)
adsorption
built,
form
Man-HMPB/HCQ.
can
facilitate
cellular
internalization
via
mannose-receptor
mediated
endocytosis
induce
TAM
polarization
iron
ion/HCQ
release
HMPB
degradation.
The
hybrid
macrophage
thylakoid
(TK)
membrane
camouflaged
on
Man-HMPB/HCQ
surface,
denoted
as
TK-M@Man-HMPB/HCQ,
reduce
in
vivo
reticuloendothelial
system
uptake,
enhance
tumor
accumulation,
mitigate
hypoxia.
results
indicate
that
TK-M@Man-HMPB/HCQ
notably
inhibits
growth,
induces
polarization,
facilitates
cytotoxic
T
lymphocytes
infiltration,
alleviates
microenvironment.
rational
design
may
provide
new
pathway
modulate
microenvironment
promoting
immunotherapy
effects.
Acta Pharmaceutica Sinica B,
Journal Year:
2023,
Volume and Issue:
13(11), P. 4391 - 4416
Published: May 20, 2023
Owing
to
the
inherent
shortcomings
of
traditional
therapeutic
drugs
in
terms
inadequate
efficacy
and
toxicity
clinical
treatment,
nanomedicine
designs
have
received
widespread
attention
with
significantly
improved
reduced
non-target
side
effects.
Nanomedicines
hold
tremendous
theranostic
potential
for
treating,
monitoring,
diagnosing,
controlling
various
diseases
are
attracting
an
unfathomable
amount
input
research
resources.
Against
backdrop
exponentially
growing
number
publications,
it
is
imperative
help
audience
get
a
panorama
image
activities
field
nanomedicines.
Herein,
this
review
elaborates
on
development
trends
nanomedicines,
emerging
nanocarriers,
vivo
fate
safety
their
extensive
applications.
Moreover,
challenges
obstacles
hindering
translation
nanomedicines
also
discussed.
The
elaboration
aspects
may
enlighten
readers
set
route
future
endeavors.
Abstract
Poly(lactic‐
co
‐glycolic
acid)
(PLGA)
nanoparticles
(NPs)
are
commonly
used
for
drug
delivery
because
of
their
favored
biocompatibility
and
suitability
sustained
controlled
release.
To
prolong
NP
circulation
time,
enable
target‐specific
overcome
physiological
barriers,
NPs
camouflaged
in
cell
membranes
have
been
developed
evaluated
to
improve
delivery.
Here,
we
discuss
recent
advances
membrane‐coated
PLGA
NPs,
preparation
methods,
application
cancer
therapy,
management
inflammation,
treatment
cardiovascular
disease
control
infection.
We
address
the
current
challenges
highlight
future
research
directions
needed
effective
use
membrane‐camouflaged
NPs.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
34(46)
Published: Dec. 8, 2021
Multiple
myeloma
(MM)
is
the
second
most
common
hematological
malignancy.
It
characterized
by
abnormal
transformation
and
uncontrolled
clonal
proliferation
of
malignant
plasma
cells
in
bone
marrow
(BM),
which
can
destroy
structure
inhibit
hematopoiesis.
Although
there
are
new
therapeutic
methods,
they
not
curative,
mainly
because
it
difficult
to
deliver
an
effective
amount
drug
BM,
leading
a
failure
eradicate
MM
inside
BM.
BM
homing
important
unique
characteristic
affected
surface
molecules
on
tumor
cell
membrane.
Inspired
this
mechanism,
MM-mimicking
nanocarrier
developed
coating
bortezomib
(BTZ)-loaded
poly(ε-caprolactone)-poly(ethylene
glycol)-poly(ε-caprolactone)
(PCEC)
nanoparticles
with
The
enter
based
as
"Trojan
horse"
target
through
homologous
targeting.
In
way,
availability
at
site
enhanced
so
growth.
addition,
these
escape
phagocytosis
MPS
have
long
circulation
effect.
vivo
results
demonstrate
excellent
treatment
efficacy
for
MM.
Accordingly,
strategy
may
be
promising
platform
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(16)
Published: March 31, 2022
Abstract
The
blood–brain
barrier
(BBB)
severely
blocks
the
intracranial
accumulation
of
most
systemic
drugs.
Inspired
by
contribution
bacterial
outer
membrane
to
Escherichia
coli
K1
(EC‐K1)
binding
and
invasion
BBB
endothelial
cells
in
meningitis,
utilization
ability
EC‐K1
for
brain‐targeted
drug
delivery
construction
a
biomimetic
self‐assembled
nanoparticle
with
surface
featuring
lipopolysaccharide‐free
are
proposed.
penetration
nanoparticles
is
demonstrated
occur
through
transcellular
vesicle
transport
pathway,
which
at
least
partially
dependent
on
internalization,
endosomal
escape,
transcytosis
mediated
interactions
between
protein
A
gp96
cells.
This
nanoengineering
strategy
endows
loaded
drugs
prolonged
circulation,
interstitial
distribution,
extremely
high
biocompatibility.
Based
critical
roles
cancer
biology,
this
reveals
enormous
potential
delivering
therapeutics
treat
gp96‐overexpressing
malignancies.
Theranostics,
Journal Year:
2022,
Volume and Issue:
13(1), P. 20 - 39
Published: Nov. 29, 2022
Currently,
biological
membrane-derived
nanoparticles
(NPs)
have
shown
enormous
potential
as
drug
delivery
vehicles
due
to
their
outstanding
biomimetic
properties.To
make
these
NPs
more
adaptive
complex
systems,
some
methods
been
developed
modify
biomembranes
and
endow
them
with
functions
while
preserving
inherent
natures.In
this
review,
we
introduce
five
common
approaches
used
for
biomembrane
decoration:
membrane
hybridization,
the
postinsertion
method,
chemical
methods,
metabolism
engineering
gene
engineering.These
can
functionalize
a
series
of
derived
from
red
blood
cells,
white
tumor
platelets,
exosomes
so
on.Biomembrane
could
markedly
facilitate
targeted
delivery,
treatment
diagnosis
cancer,
inflammation,
immunological
diseases,
bone
diseases
Alzheimer's
disease.It
is
anticipated
that
modification
techniques
will
advance
biomembrane-derived
into
broader
applications
in
future.
