Journal of Clinical Monitoring and Computing, Journal Year: 2023, Volume and Issue: 38(2), P. 455 - 461
Published: Dec. 29, 2023
Language: Английский
Critical Care, Journal Year: 2023, Volume and Issue: 27(1)
Published: Feb. 28, 2023
Abstract Background During high-flow nasal cannula (HFNC) therapy, flow plays a crucial role in the physiological effects. However, there is no consensus on initial settings and subsequent titration. Thus, we aimed to systematically synthesize effects of flows during HFNC treatment. Methods In this systematic review, two investigators independently searched PubMed, Embase, Web Science, Scopus, Cochrane for vitro vivo studies investigating treatment published English before July 10, 2022. We excluded that investigated pediatric population (< 18 years) or used only one flow. Two extracted data assessed risk bias. The study protocol was prospectively registered with PROSPERO, CRD42022345419. Results total, 32,543 were identified, 44 included. evaluated fraction inspired oxygen (F I O 2 ), positive end-expiratory pressure, carbon dioxide (CO ) washout. These are flow-dependent maximized when exceeds patient peak inspiratory flow, which varies between patients disease conditions. report higher result improved oxygenation dead space washout can reduce work breathing. Higher also lead alveolar overdistention non-dependent lung regions discomfort. impact different largely heterogeneous. Interpretation Individualizing necessary, titrating based clinical findings like oxygenation, respiratory rates, ROX index, comfort pragmatic way forward.
Language: Английский
Citations
28
Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12
Published: May 9, 2025
Background High-flow nasal cannula (HFNC) delivers a continuous, unidirectional high flow of oxygen (Uniflow) throughout the respiratory cycle. Despite its positive pressure effects in nasopharynx, persistent during expiration imposes additional work breathing and disrupts patient’s neural We devised bi-level high-flow system (Biflow) allowing separate rate adjustments for inspiration expiration. Methods conducted randomized crossover pilot study which we included healthy volunteer at ASAN Medical Center (April 2021 to June 2021). The data 12 volunteers (7 male, 5 female, average age 46.3 years) were analyzed. For Uniflow, settings 30 (U30), 40 (U40), 50 (U50) L/min tested. In Biflow, inspiratory rates matched Uniflow settings, while expiratory varied from 10 L/min. sequence each (Uniflow vs. Biflow) was setting maintained 3 min. Physiologic parameters, nasopharyngeal pressure-time product (N-PTP) as an energy cost proxy, end-expiratory lung impedance (EELI), participant comfort assessed. Results decreased elongated time compared natural breathing. However, these less pronounced Biflow. Compared with both N-PTP lower Transcutaneous CO 2 Biflow or Uniflow. EELI did not differ between modes. All participants completed protocol without side effects. Conclusion participants, conventional HFNC (Uniflow), showed interference cycle participants. occurring nasopharynx Clinical trial registration http://cris.nih.go.kr/cris/ , identifier KCT0006100.
Language: Английский
Citations
0
Nursing in Critical Care, Journal Year: 2024, Volume and Issue: 29(6), P. 1489 - 1495
Published: Feb. 6, 2024
Patients with respiratory disease often need oxygen supplements through a High-flow nasal cannula (HFNC), both hypoxia and hyperoxia can be harmful. Proper therapy requires careful monitoring of levels adjustments to levels. A new automated system called Targeted SpO2 Feedback (TSF) improved the delivery compared manual adjustments. [Correction added on 25 October 2024, after first online publication: Background subsection in Abstract has been this version.] AIM: To test whether targeted feedback (TSF), an automatic control for fraction inspired (FiO2), achieves more time optimal range and/or reduces frequency administered FiO2 conventional titration patients high-flow (HFNC) therapy.
Language: Английский
Citations
1
Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(8), P. 2878 - 2878
Published: April 14, 2023
This article is a review of the physiological and technological processes underpinning high-flow nasal therapy with oxygen (HFNT or HFOT) for treatment hypoxemic respiratory failure. A mathematical model was carefully built to represent relationships between settings on HFNT device resultant diffusion into hypoxemic, arterial blood. The analysis used recommend strategy setting flow rate at above patient's peak inspiratory when blender equal bleed-in used. also teaches how titrate achieve desired fraction inhaled oxygen, (FiO2), in trachea using simple ratio compare as method improve efficacy other forms therapy. this relates HFOT/HFNT that CPAP supplemental by computing versus breathing room air. We predicted non-atelectatic lungs, considering oxygenation, can be equally effective treating
Language: Английский
Citations
2
Acute and Critical Care, Journal Year: 2023, Volume and Issue: 38(4), P. 435 - 441
Published: Nov. 23, 2023
Concerns regarding positive-pressure-ventilation for the treatment of coronavirus disease 2019 (COVID-19) hypoxemia led search alternative oxygenation techniques. This study aimed to assess one such method, dual oxygenation, i.e., addition a reservoir mask (RM) on top high-flow nasal cannula (HFNC).In this retrospective cohort study, records all patients hospitalized with COVID-19 during 2020-2022 were reviewed. Patients over age 18 years necessitating HFNC included. Exclusion criteria any indication other than hypoxemic respiratory failure, transfer another facility while still and "do-not-intubate/resuscitate" orders. The primary outcome was mortality within 30 days from first application HFNC. Secondary outcomes intubation admission intensive care unit.Of 659 included in final analysis, 316 treated 343 alone. Propensity estimated based background diagnoses, laboratories vital signs upon admission, gender glucocorticoid dose. Inverse probability weighted regression including age, body mass index, Sequential Organ Failure Assessment (SOFA) score rate index showed be associated lower 30-day (adjusted hazard ratio, 0.615; 95% confidence interval, 0.469-0.809). Differences secondary did not reach statistical significance.Our suggests that RM may decreased severe hypoxemia.
Language: Английский
Citations
1
Respiratory Care, Journal Year: 2024, Volume and Issue: 69(7), P. 847 - 853
Published: March 14, 2024
Optimal aerosol delivery methods for spontaneously breathing patients with a tracheostomy remain unclear. Thus, we aimed to assess the impact of nebulizer placement, flow settings, and interfaces on by using vibrating mesh jet in line unheated humidification.
Language: Английский
Citations
0
Therapeutic Advances in Respiratory Disease, Journal Year: 2024, Volume and Issue: 18
Published: Jan. 1, 2024
Background: Although high-flow nasal cannula (HFNC) oxygenation is currently recommended to prevent desaturation during sedation for bronchoscopy, there no consensus on an optimal flow rate. Objective: To determine the oxygen rate HFNC effectively bronchoscopy. Design: Prospective, randomized, and controlled study. Methods: Patients ( n = 240) scheduled bronchoscopy were randomized receive with propofol (fraction of inspired oxygen, 100%) at one six rates 10, 20, 30, 40, 50, 60 L/min, designated as groups 1–6, respectively. Results: The incidence significantly decreased by increasing (42.5%, 17.5%, 15%, 10%, 2.5%, 0% respectively, p < 0.0001). determined probit regression in 95% patients was 43.20 (95% confidence interval, 36.43–55.96) L/min. requirement airway intervention Conclusion: An 50–60 L/min Registration: NCT05298319 ClinicalTrials.gov.
Language: Английский
Citations
0
Journal of the Formosan Medical Association, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 1, 2024
Purpose: High-flow nasal cannula (HFNC) has many benefits in various clinical conditions. The original hypothesis suggests that the high and constant fraction of inspired oxygen (FiO
Language: Английский
Citations
0
Journal of Clinical Monitoring and Computing, Journal Year: 2023, Volume and Issue: 38(2), P. 455 - 461
Published: Dec. 29, 2023
Language: Английский
Citations
0