Isatin Conjugates as Antibacterial Agents: A Brief Review DOI
Firoj Hassan, Iqbal Azad, Mohd Asif

et al.

Medicinal Chemistry, Journal Year: 2022, Volume and Issue: 19(5), P. 413 - 430

Published: Sept. 30, 2022

Abstract: Pathogenic bacteria, with their innate resistance to drugs, pose a constant threat human health and well-being put persistent strain on the care system. Development of more effective safer novel antibacterial drugs is warranted counter menace unleashed by pathogenic bacteria. Integration privileged pharmacophores from various bioactive molecules into single template promising strategy obtain new leads unique mechanisms action overcome drug resistance. In past few years, numerous isatin-based hybrid were screened pharmacological properties explored in efforts develop therapeutics. The results screening show that isatin conjugates exhibit activity against broad range highly gram-positive gram-negative bacteria can serve as important discovery potent spectrum drugs. Herein, we review profile variety derivatives, including isatin–azole, isatin-quinoline/ quinolone, isatin-furan/coumarin, isatin-hydrazone/(thio)semicarbazone, dimers, isatin– indole hybrids.

Language: Английский

Characterization and Optimization of Polymeric Bispicolamine Chelating Resin: Performance Evaluation via RSM Using Copper in Acid Liquors as a Model Substrate through Ion Exchange Method DOI Creative Commons
Kowit Suwannahong,

Chadrudee Sirilamduan,

Anat Deepatana

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(21), P. 7210 - 7210

Published: Oct. 25, 2022

Advanced technologies of electronics industries have led to environmental contamination concerns, especially waste print circuit boards containing a very high concentration copper (II) ions, which can be discharged in wastewater many contaminated metals. A low pH is necessity for treating industrial heavy metals meet engineering process design. novel polymeric bispicolamine chelating resin, Dowex-M4195, was applied as an alternative investigating the behavior acidic solution via ion exchange method batch experiment system. Characterization physical and chemical properties before after were also explored through BET, SEM-EDX, FTIR XRD. Response surface methodology optimization removal capacity using design selective resin at pH. The results indicate that H+ Dowex-M4195 had high-carbon content specific area >64% 26.5060 m2/g, respectively. It predominantly macropore porous nature due N2 gas adsorption isotherm exhibited type IV with insignificant desorption hysteresis loop H1-type. spherical cylindrical. After (II)-loaded total pore volume decreased by about 17.82% 5.39%, respectively, compared Dowex-M4195. Hysteresis loop, size distribution similar. Regarding functional group, morphology crystalline structures showed compound based on structure confirmed effective behavior. indicated 31.33 mg/g achieved, could obtained 6.96 h, 2 (a desirable pH), dose 124.13 mg 525.15 mg/L. study (which commercially available market) successfully precursor further reuse regeneration electronic other applications needed respond policy biocircular green economy Thailand.

Language: Английский

Citations

21
Creating intense and refined NLO responses by utilizing dual donor structural designs in A-π-D-π-D-π-A type organic switches: computed device parameters DOI

Abrar U. Hassan,

Sajjad Hussain Sumrra, Ghulam Mustafa

et al.

Structural Chemistry, Journal Year: 2023, Volume and Issue: 34(6), P. 2021 - 2038

Published: Feb. 13, 2023

Language: Английский

Citations

12
An Insight into the Effect of Schiff Base and their d and f Block Metal Complexes on Various Cancer Cell Lines as Anticancer Agents: A Review DOI

Presenjit,

Shubhra Chaturvedi, Akanksha Singh

et al.

Anti-Cancer Agents in Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 24(7), P. 488 - 503

Published: Jan. 26, 2024

Abstract: Over the last few decades, an alarming rise in percentage of individuals with cancer and those multi-resistant illnesses has forced researchers to explore possibilities for novel therapeutic approaches. Numerous medications currently exist treat various disorders, development small molecules as anticancer agents considerable potential. However, widespread prevalence resistance multiple drugs indicates that it is necessary discover promising compounds ideal characteristics could overcome multidrug issue. The utilisation metallo-drugs served a productive chemotherapeutic method, this approach may be implemented combating tumours more successfully. Schiff bases have been receiving lot attention group due their adaptable metal chelating abilities, innate biologic properties, versatility tweak structure optimise specific biological purpose. relevance base related complexes, notably effects, increased popularity bio-inorganic chemistry progressed. As result learning about antitumor efficacy against cell lines are motivated develop novel, side-effect-free treatments. According study reports from past ten years, we still seeking powerful contender. This highlights potential bases, broad class chemical molecules, potent agents. In combination other strategies, they enhance treatment by elevating cytotoxicity chemotherapy, surmounting drug resistance, promoting targeted therapy. also cause DNA repair, improve immunotherapy, prevent angiogenesis, apoptosis, lessen side effects chemotherapy. present review explores d f block complexes lines.

Language: Английский

Citations

4
Influence of benzothiophene acceptor moieties on the non-linear optical properties of pyreno-based chromophores: first-principles DFT framework DOI Creative Commons
Iqra Shafiq, S. Haq,

Tayyaba Javed

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(23), P. 15964 - 15978

Published: Jan. 1, 2024

Herein, a series of heterocyclic organic compounds (PYFD1-PYFD7) are designed with different acceptor moieties at the terminal position reference compound (PYFR) for nonlinear optical (NLO) active materials. The optoelectronic characteristics chromophores were investigated using density functional theory (DFT) calculations M06/6-311G(d,p) functional. Frontier molecular orbital (FMO) analysis revealed significant decrease in energy band gaps (2.340-2.602 eV) derivatives as compared to PYFR (3.12 eV). An efficient transfer charge from highest occupied (HOMO) lowest unoccupied (LUMO) was seen, which further corroborated by states (DOS) and transition matrix (TDM) heat maps. results global reactivity parameters (GRPs) indicated that all exhibited greater softness (σ = 0.384-0.427 lower hardness (η 0.394-1.302 PYFR, indicating higher level polarizability derivatives. Moreover, showed findings terms chromophore. PYFD2 most effective NLO response (α 1.861 × 10-22 βtot 2.376 10-28 esu), including lowered gap 2.340 eV, maximum value 0.4273 1.170 eV other chromophores. incorporation acceptors thiophene π-spacer this structural alteration significantly contributed achieving remarkable responses. Therefore, our may motivate experimentalists synthesize these materials current advanced technological applications.

Language: Английский

Citations

4
Isatin Conjugates as Antibacterial Agents: A Brief Review DOI
Firoj Hassan, Iqbal Azad, Mohd Asif

et al.

Medicinal Chemistry, Journal Year: 2022, Volume and Issue: 19(5), P. 413 - 430

Published: Sept. 30, 2022

Abstract: Pathogenic bacteria, with their innate resistance to drugs, pose a constant threat human health and well-being put persistent strain on the care system. Development of more effective safer novel antibacterial drugs is warranted counter menace unleashed by pathogenic bacteria. Integration privileged pharmacophores from various bioactive molecules into single template promising strategy obtain new leads unique mechanisms action overcome drug resistance. In past few years, numerous isatin-based hybrid were screened pharmacological properties explored in efforts develop therapeutics. The results screening show that isatin conjugates exhibit activity against broad range highly gram-positive gram-negative bacteria can serve as important discovery potent spectrum drugs. Herein, we review profile variety derivatives, including isatin–azole, isatin-quinoline/ quinolone, isatin-furan/coumarin, isatin-hydrazone/(thio)semicarbazone, dimers, isatin– indole hybrids.

Language: Английский

Citations

17