Breast Cancer Treatment: The Potential of Organic and Inorganic Nanocarriers in Targeted Drug Delivery DOI Creative Commons

Saravanan Alamelu,

Kamalesh Balakumar Venkatesan, Kalist Shagirtha

et al.

Drugs and Drug Candidates, Journal Year: 2024, Volume and Issue: 3(4), P. 813 - 837

Published: Nov. 25, 2024

Breast cancer (BC) is the most prevalent form of malignancy among women on a global scale, ranking alongside lung cancer. Presently, conventional approaches to treatment include surgical procedures followed by chemotherapy or radiotherapy. Nonetheless, efficacy these treatments in battling BC often compromised due adverse effects they inflict healthy tissues and organs. In recent times, range nanoparticles (NPs) has emerged, exhibiting potential specifically target malignant cells while sparing normal organs from harm. This paved way for development nanoparticle-mediated targeted drug delivery systems, holding great promise as technique addressing BC. To increase this new method, several nanocarriers including inorganic NPs (such magnetic NPs, silica etc.) organic (e.g., dendrimers, liposomes, micelles, polymeric NPs) have been used. Herein, we discuss mechanism NP-targeted advancement therapeutic strategies anticancer We also future prospects challenges nanoparticle-based therapies

Language: Английский

Recent Progress and Challenges Regarding Magnetite-Based Nanoparticles for Targeted Drug Delivery DOI Creative Commons
Joanna Kurczewska, Bernadeta Dobosz

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(3), P. 1132 - 1132

Published: Jan. 29, 2024

Magnetite-based nanoparticles are of constant interest in the scientific community as potential systems for biomedical applications. Over years, ability to synthesize diverse based on iron (II, III) oxide has been mastered maximize their effectiveness targeted delivery active substances cancer therapy. The present review explores recent literature findings that detail various magnetic nanosystems. These encompass straightforward designs featuring a polymer coating core and more intricate matrices delivering chemotherapeutic drugs. This paper emphasizes novel synthetic approaches impact efficacy progress anticancer investigations, specifically targeting particular type. research also delves into combinations with alternative treatment methods diagnostic approaches. Additionally, it highlights critical aspect—the interaction cells—identifying least developed aspect current these systems.

Language: Английский

Citations

8

Tannic acid chitosan iron oxide nanocomposite for cervical cancer treatment DOI
Farahnaz Barahuie, Dena Dorniani, Bullo Saifullah

et al.

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 162, P. 112160 - 112160

Published: Feb. 5, 2024

Language: Английский

Citations

5

Exploring the Potential of Nanoparticles in the Treatment of Breast Cancer: Current Applications and Future Directions DOI Creative Commons
Puja Patel, Vadanasundari Vedarethinam,

Maame A. Korsah

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(5), P. 1809 - 1809

Published: Feb. 22, 2024

Breast cancer (BC) ranks among the most diagnosed solid tumors worldwide. For decades, significant research efforts have been dedicated to finding selective treatments for these tumors. Currently, primary treatment method BC involves surgery, with subsequent utilization of radiotherapy and chemotherapy. However, often fall short effectively treating due their side effects harm healthy tissues. Today, a range nanoparticles are being developed target cells without affecting surrounding This in-depth review, based on studies, seeks shed light specially designed potential in treatment. Typically, therapeutic drugs or naturally occurring bioactive compounds incorporated into precisely crafted nanoparticles. enhances solubility, longevity bloodstream, distribution body while also minimizing immune reactions. Nanoparticles address shortcomings standalone therapeutics traverse various biological obstacles spanning systemic, microenvironmental, cellular that differ patients diseases. We prioritize breakthroughs nanoparticle design surpass diverse delivery believe smart engineering not only effectiveness general but allows customized solutions specific needs, ultimately leading better outcomes patients.

Language: Английский

Citations

4

Carbon Nanomaterials (CNMs) in Cancer Therapy: A Database of CNM-Based Nanocarrier Systems DOI Creative Commons
Hugh Mohan, Andrew Fagan, Silvia Giordani

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(5), P. 1545 - 1545

Published: May 19, 2023

Carbon nanomaterials (CNMs) are an incredibly versatile class of materials that can be used as scaffolds to construct anticancer nanocarrier systems. The ease chemical functionalisation, biocompatibility, and intrinsic therapeutic capabilities many these nanoparticles leveraged design effective This article is the first comprehensive review CNM-based systems incorporate approved chemotherapy drugs, different types CNMs agents discussed. Almost 200 examples have been analysed compiled into a database. entries organised by drug type, composition, loading/release metrics, experimental results from compiled. Our analysis reveals graphene, particularly graphene oxide (GO), most frequently employed CNM, with carbon nanotubes dots following in popularity. Moreover, database encompasses various chemotherapeutic agents, antimicrotubule being common payload due their compatibility CNM surfaces. benefits identified discussed, factors affecting efficacy detailed.

Language: Английский

Citations

10

A review of chitosan-functionalized graphene oxide nanocomposites: A revolutionary drug delivery vehicle for cancer therapy DOI

Prachika Rajput,

Sunita Khanchandani

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143999 - 143999

Published: May 1, 2025

Language: Английский

Citations

0

Recent trending insights for enhancing silicon anode in lithium-ion battery via polymer coating DOI

Sarah L. Ibrahem,

Mostafa Y. Nassar,

Sherine M. Abd El. Kader

et al.

Ionics, Journal Year: 2024, Volume and Issue: 30(10), P. 5879 - 5901

Published: Aug. 9, 2024

Language: Английский

Citations

3

Development of quercetin loaded biosynthesized chitosan grafted iron oxide nanoformulationand their antibacterial and anti-cancer, andantioxidant properties DOI
Mohammed Ali Alshehri, Chellasamy Panneerselvam

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106247 - 106247

Published: Oct. 1, 2024

Language: Английский

Citations

2

Physicochemical Properties and Release Study of Antimetabolite-Incorporated Stearoyl Chitosan DOI Creative Commons
Anita Marlina, Misni Misran

ACS Omega, Journal Year: 2023, Volume and Issue: 8(43), P. 40494 - 40507

Published: Oct. 20, 2023

Stearoyl chitosan (SC), derived from the acylation of chitosan, contributes to efficiency drug delivery systems because its structure, which accommodates in a particle. Nonetheless, role chemotherapy has been largely unexplored. The present study involves synthesis stearoyl through reaction depolymerized with chloride under mild conditions. resulting compound was subjected structural analysis utilizing Fourier-transform infrared (FTIR) spectroscopy, 1H NMR, and X-ray diffraction (XRD) spectroscopy. dispersion SC molecules phosphate-buffered saline (PBS) forms nanoparticles. best solution achieved at 1:60 chitosan-to-stearoyl weight ratio. Three antimetabolite drugs, methotrexate, pemetrexed, raltitrexed, were selected examine loading efficacy SC. Pemetrexed had highest drug-loading value 36.8% among three antimetabolites incorporated into SC, along an encapsulation 85.1%. size loaded ranged 225 369 nm, their spherical form verified via transmission electron microscope. vitro release showed that demonstrated controlled release, suggesting nanoparticles have significant promise as strategy for chemotherapy.

Language: Английский

Citations

4

Efficacy of alumina nanoparticles as a controllable tool for mortality and biochemical parameters of Culex pipiens DOI Creative Commons

Nehad El-Barkey,

Mostafa Y. Nassar,

Aya H. El‐Khawaga

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Nov. 10, 2023

Mosquitoes still pose a clear risk to human and animal health. Recently, nanomaterials have been considered one of the cost-effective solutions this problem. Therefore, alumina nanoparticles (Al) were synthesized using an auto-combustion method, followed by calcination at 600 800 °C. Glucose (G) sucrose (Su) used as fuels combustion was performed pH 2, 7, 10. The as-synthesized Al2O3 characterized XRD, FTIR, SEM, TEM. Alumina prepared G Su 7 °C (Al-G7-800 Al-Su7-800) crystallite sizes 3.9 4.05 nm, respectively. While samples (Al-G7-600 Al-Su7-600) amorphous. applied larval pupal stages Culex pipiens. results showed that cause higher mortality in 1st instar than all other instars pipiens after treatment high concentration 200 ppm. Additionally, duration with LC50 concentrations 31.7 23.6 days, respectively, compared control (13.3 days). recorded data found content glutathione-S-transferase, alkaline/acid phosphatase, β/α-esterase, total protein altered upon (Al-G7-800) nanoparticles. Based on these findings, are promising candidate potential weapon pests mosquitoes.

Language: Английский

Citations

4

Hybrid nanoarchitecture of gelatin-modified silica-chitosan as an efficient delivery platform and functional role of crosslinking DOI

Zahra Niazi,

Mohsen Ashjari

International Journal of Polymeric Materials, Journal Year: 2023, Volume and Issue: 73(15), P. 1291 - 1304

Published: Nov. 15, 2023

A novel hybrid of a quercetin-loaded silica-chitosan, modified by crosslinked gelatin-folate was developed in the current study as pH-sensitive drug delivery system. The entrapment efficiency quercetin measured at about 77%. release pattern investigated acidic and natural media (pH 5.6 pH = 7.4) for 96 h. In-vitro from unmodified carriers exhibited rapid early times (57 39% after 24 h neutral media), which followed slower release. However, behavior improved modifying carrier with layer. In addition, further rate observed gelatin-modified an medium (31% h) compared to condition (20% h), confirming behavior. Furthermore, cumulative silica-chitosan approximately slow release, so that 23% 15% released conditions, respectively. date described Higuchi model, suggesting both diffusion polymer swelling control process. high loading, pH-triggered behavior, controlled platform, combined low toxicity, render this designed applicable targeted delivery.

Language: Английский

Citations

4