Drugs and Drug Candidates,
Journal Year:
2024,
Volume and Issue:
3(4), P. 813 - 837
Published: Nov. 25, 2024
Breast
cancer
(BC)
is
the
most
prevalent
form
of
malignancy
among
women
on
a
global
scale,
ranking
alongside
lung
cancer.
Presently,
conventional
approaches
to
treatment
include
surgical
procedures
followed
by
chemotherapy
or
radiotherapy.
Nonetheless,
efficacy
these
treatments
in
battling
BC
often
compromised
due
adverse
effects
they
inflict
healthy
tissues
and
organs.
In
recent
times,
range
nanoparticles
(NPs)
has
emerged,
exhibiting
potential
specifically
target
malignant
cells
while
sparing
normal
organs
from
harm.
This
paved
way
for
development
nanoparticle-mediated
targeted
drug
delivery
systems,
holding
great
promise
as
technique
addressing
BC.
To
increase
this
new
method,
several
nanocarriers
including
inorganic
NPs
(such
magnetic
NPs,
silica
etc.)
organic
(e.g.,
dendrimers,
liposomes,
micelles,
polymeric
NPs)
have
been
used.
Herein,
we
discuss
mechanism
NP-targeted
advancement
therapeutic
strategies
anticancer
We
also
future
prospects
challenges
nanoparticle-based
therapies
Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(3), P. 1132 - 1132
Published: Jan. 29, 2024
Magnetite-based
nanoparticles
are
of
constant
interest
in
the
scientific
community
as
potential
systems
for
biomedical
applications.
Over
years,
ability
to
synthesize
diverse
based
on
iron
(II,
III)
oxide
has
been
mastered
maximize
their
effectiveness
targeted
delivery
active
substances
cancer
therapy.
The
present
review
explores
recent
literature
findings
that
detail
various
magnetic
nanosystems.
These
encompass
straightforward
designs
featuring
a
polymer
coating
core
and
more
intricate
matrices
delivering
chemotherapeutic
drugs.
This
paper
emphasizes
novel
synthetic
approaches
impact
efficacy
progress
anticancer
investigations,
specifically
targeting
particular
type.
research
also
delves
into
combinations
with
alternative
treatment
methods
diagnostic
approaches.
Additionally,
it
highlights
critical
aspect—the
interaction
cells—identifying
least
developed
aspect
current
these
systems.
Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(5), P. 1809 - 1809
Published: Feb. 22, 2024
Breast
cancer
(BC)
ranks
among
the
most
diagnosed
solid
tumors
worldwide.
For
decades,
significant
research
efforts
have
been
dedicated
to
finding
selective
treatments
for
these
tumors.
Currently,
primary
treatment
method
BC
involves
surgery,
with
subsequent
utilization
of
radiotherapy
and
chemotherapy.
However,
often
fall
short
effectively
treating
due
their
side
effects
harm
healthy
tissues.
Today,
a
range
nanoparticles
are
being
developed
target
cells
without
affecting
surrounding
This
in-depth
review,
based
on
studies,
seeks
shed
light
specially
designed
potential
in
treatment.
Typically,
therapeutic
drugs
or
naturally
occurring
bioactive
compounds
incorporated
into
precisely
crafted
nanoparticles.
enhances
solubility,
longevity
bloodstream,
distribution
body
while
also
minimizing
immune
reactions.
Nanoparticles
address
shortcomings
standalone
therapeutics
traverse
various
biological
obstacles
spanning
systemic,
microenvironmental,
cellular
that
differ
patients
diseases.
We
prioritize
breakthroughs
nanoparticle
design
surpass
diverse
delivery
believe
smart
engineering
not
only
effectiveness
general
but
allows
customized
solutions
specific
needs,
ultimately
leading
better
outcomes
patients.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(5), P. 1545 - 1545
Published: May 19, 2023
Carbon
nanomaterials
(CNMs)
are
an
incredibly
versatile
class
of
materials
that
can
be
used
as
scaffolds
to
construct
anticancer
nanocarrier
systems.
The
ease
chemical
functionalisation,
biocompatibility,
and
intrinsic
therapeutic
capabilities
many
these
nanoparticles
leveraged
design
effective
This
article
is
the
first
comprehensive
review
CNM-based
systems
incorporate
approved
chemotherapy
drugs,
different
types
CNMs
agents
discussed.
Almost
200
examples
have
been
analysed
compiled
into
a
database.
entries
organised
by
drug
type,
composition,
loading/release
metrics,
experimental
results
from
compiled.
Our
analysis
reveals
graphene,
particularly
graphene
oxide
(GO),
most
frequently
employed
CNM,
with
carbon
nanotubes
dots
following
in
popularity.
Moreover,
database
encompasses
various
chemotherapeutic
agents,
antimicrotubule
being
common
payload
due
their
compatibility
CNM
surfaces.
benefits
identified
discussed,
factors
affecting
efficacy
detailed.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(43), P. 40494 - 40507
Published: Oct. 20, 2023
Stearoyl
chitosan
(SC),
derived
from
the
acylation
of
chitosan,
contributes
to
efficiency
drug
delivery
systems
because
its
structure,
which
accommodates
in
a
particle.
Nonetheless,
role
chemotherapy
has
been
largely
unexplored.
The
present
study
involves
synthesis
stearoyl
through
reaction
depolymerized
with
chloride
under
mild
conditions.
resulting
compound
was
subjected
structural
analysis
utilizing
Fourier-transform
infrared
(FTIR)
spectroscopy,
1H
NMR,
and
X-ray
diffraction
(XRD)
spectroscopy.
dispersion
SC
molecules
phosphate-buffered
saline
(PBS)
forms
nanoparticles.
best
solution
achieved
at
1:60
chitosan-to-stearoyl
weight
ratio.
Three
antimetabolite
drugs,
methotrexate,
pemetrexed,
raltitrexed,
were
selected
examine
loading
efficacy
SC.
Pemetrexed
had
highest
drug-loading
value
36.8%
among
three
antimetabolites
incorporated
into
SC,
along
an
encapsulation
85.1%.
size
loaded
ranged
225
369
nm,
their
spherical
form
verified
via
transmission
electron
microscope.
vitro
release
showed
that
demonstrated
controlled
release,
suggesting
nanoparticles
have
significant
promise
as
strategy
for
chemotherapy.
Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Nov. 10, 2023
Mosquitoes
still
pose
a
clear
risk
to
human
and
animal
health.
Recently,
nanomaterials
have
been
considered
one
of
the
cost-effective
solutions
this
problem.
Therefore,
alumina
nanoparticles
(Al)
were
synthesized
using
an
auto-combustion
method,
followed
by
calcination
at
600
800
°C.
Glucose
(G)
sucrose
(Su)
used
as
fuels
combustion
was
performed
pH
2,
7,
10.
The
as-synthesized
Al2O3
characterized
XRD,
FTIR,
SEM,
TEM.
Alumina
prepared
G
Su
7
°C
(Al-G7-800
Al-Su7-800)
crystallite
sizes
3.9
4.05
nm,
respectively.
While
samples
(Al-G7-600
Al-Su7-600)
amorphous.
applied
larval
pupal
stages
Culex
pipiens.
results
showed
that
cause
higher
mortality
in
1st
instar
than
all
other
instars
pipiens
after
treatment
high
concentration
200
ppm.
Additionally,
duration
with
LC50
concentrations
31.7
23.6
days,
respectively,
compared
control
(13.3
days).
recorded
data
found
content
glutathione-S-transferase,
alkaline/acid
phosphatase,
β/α-esterase,
total
protein
altered
upon
(Al-G7-800)
nanoparticles.
Based
on
these
findings,
are
promising
candidate
potential
weapon
pests
mosquitoes.
International Journal of Polymeric Materials,
Journal Year:
2023,
Volume and Issue:
73(15), P. 1291 - 1304
Published: Nov. 15, 2023
A
novel
hybrid
of
a
quercetin-loaded
silica-chitosan,
modified
by
crosslinked
gelatin-folate
was
developed
in
the
current
study
as
pH-sensitive
drug
delivery
system.
The
entrapment
efficiency
quercetin
measured
at
about
77%.
release
pattern
investigated
acidic
and
natural
media
(pH
5.6
pH
=
7.4)
for
96
h.
In-vitro
from
unmodified
carriers
exhibited
rapid
early
times
(57
39%
after
24
h
neutral
media),
which
followed
slower
release.
However,
behavior
improved
modifying
carrier
with
layer.
In
addition,
further
rate
observed
gelatin-modified
an
medium
(31%
h)
compared
to
condition
(20%
h),
confirming
behavior.
Furthermore,
cumulative
silica-chitosan
approximately
slow
release,
so
that
23%
15%
released
conditions,
respectively.
date
described
Higuchi
model,
suggesting
both
diffusion
polymer
swelling
control
process.
high
loading,
pH-triggered
behavior,
controlled
platform,
combined
low
toxicity,
render
this
designed
applicable
targeted
delivery.
