Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(3), P. 705 - 705
Published: March 13, 2025
The
circadian
clock
is
a
fundamental
timekeeping
system
that
regulates
rhythmic
biological
processes
in
response
to
environmental
light–dark
cycles.
In
mammals,
core
genes
(CLOCK,
BMAL1,
PER,
and
CRY)
orchestrate
these
rhythms
through
transcriptional–translational
feedback
loops,
influencing
various
physiological
functions,
including
bone
remodeling.
Bone
homeostasis
relies
on
the
coordinated
activities
of
osteoblasts,
osteoclasts,
osteocytes,
with
increasing
evidence
highlighting
role
regulation
maintaining
skeletal
integrity.
Disruptions
are
linked
disorders
such
as
osteoporosis.
Posttranslational
modifications
(PTMs),
phosphorylation,
acetylation,
ubiquitination,
serve
crucial
regulators
both
mechanisms
metabolism.
However,
specific
PTMs
integrating
timing
remodeling
remains
underexplored.
This
review
examines
intersection
biology,
elucidating
their
impact
cell
function
homeostasis.
Understanding
interactions
may
uncover
novel
therapeutic
targets
for
diseases
associated
disruptions.
Life,
Journal Year:
2023,
Volume and Issue:
13(10), P. 1968 - 1968
Published: Sept. 26, 2023
Environmental
light
entrains
many
physiological
and
behavioural
processes
to
the
24
h
solar
cycle.
Such
light-driven
circadian
rhythms
are
centrally
controlled
by
suprachiasmatic
nucleus
(SCN),
which
receives
information
from
short-wavelength-sensitive
intrinsically
photosensitive
retinal
ganglion
cells.
The
SCN
synchronizes
local
clocks
throughout
body
affecting
sleep/wake
routines
secretion
of
neuroendocrine-linked
hormones
such
as
melatonin
pineal
gland
cortisol
via
hypothalamic
pituitary
adrenal
(HPA)
axis.
Although
effects
parameters
on
have
been
recently
reviewed,
whether
experimental
variation
spectral
power
distribution
intensity
can
induce
changes
in
remains
unclear.
Thus,
this
systematic
review
evaluated
daytime
exposure
lights
different
wavelength
characteristics
luminance
levels
healthy
individuals.
A
search
PubMed,
Web
Science,
EMBASE,
CINAHL,
Medline,
PsycINFO
Cochrane
Library
databases
19
June
2023
identified
3418
articles,
12
studies
(profiling
337
participants)
met
inclusion
risk
bias
criteria.
An
analysis
literature
indicated
that
bright
any
colour
during
late
night
or
early
morning
significant
increases
relative
time-matched
dim
comparison
conditions.
Furthermore,
with
stronger
short-wavelength
(blue/green)
components
typically
induced
greater
long-wavelength
(red)
components.
regulation
is
sensitive
composition
environmental
lighting,
line
more
commonly
studied
melatonin.
As
such,
should
be
optimized
reported
intervention
(particularly
for
investigation
cortisol-associated
disorders
HPA
axis
function),
periods
carefully
considered
constructed
environments
(e.g.,
bedroom
classroom
lighting
device
screens).
World Journal of Clinical Oncology,
Journal Year:
2024,
Volume and Issue:
15(7), P. 818 - 834
Published: July 16, 2024
This
review
delved
into
the
intricate
relationship
between
circadian
clocks
and
physiological
processes,
emphasizing
their
critical
role
in
maintaining
homeostasis.
Orchestrated
by
interlocked
clock
genes,
timekeeping
system
regulates
fundamental
processes
like
sleep-wake
cycle,
energy
metabolism,
immune
function,
cell
proliferation.
The
central
oscillator
hypothalamic
suprachiasmatic
nucleus
synchronizes
with
light-dark
cycles,
while
peripheral
tissue
are
influenced
cues
such
as
feeding
times.
Circadian
disruption,
linked
to
modern
lifestyle
factors
night
shift
work,
correlates
adverse
health
outcomes,
including
metabolic
syndrome,
cardiovascular
diseases,
infections,
cancer.
We
explored
molecular
mechanisms
of
genes
impact
on
disorders
cancer
pathogenesis.
Specific
associations
disruption
endocrine
tumors,
spanning
breast,
ovarian,
testicular,
prostate,
thyroid,
pituitary,
adrenal
gland
cancers,
highlighted.
Shift
work
is
associated
increased
breast
risk,
Asian Journal of Pharmaceutical Research,
Journal Year:
2024,
Volume and Issue:
unknown, P. 309 - 314
Published: Sept. 20, 2024
As
modern
technologies
advance,
new
methods
of
drug
delivery
systems
are
constantly
being
developed.
Pulsatile
system
is
becoming
increasingly
popular
because
it
can
deliver
the
at
correct
location,
time,
and
dosage,
improving
patient
adherence.
These
designed
to
align
with
body's
inherent
circadian
rhythm.
release
mainly
preferred
when
continuous
not
needed.
Understanding
clock's
design,
illness
rhythm
pathophysiology,
chrono
pharmacology’s
medication
knowledge
helps
create
utilize
chronotherapeutic
dosage
forms
for
effective
disease
treatment,
reducing
side
effects,
targeted
delivery,
maintaining
consistent
dosing.
Proper
design
pulsatile
enhances
adherence,
targets
distribution,
decreases
effects.
Like
many
other
medical
conditions,
outlook
chronotherapy
using
seems
very
optimistic.
either
one
or
multiple
mechanisms
administer
a
specific
time
location.
Formulation
flow
achieved
by
incorporating
different
polymers,
thickness
coating
layer
dictating
speed
active
medicinal
ingredient.
Frontiers in Neuroscience,
Journal Year:
2021,
Volume and Issue:
15
Published: Oct. 7, 2021
Current
approaches
to
quantify
and
diagnose
sleep
disorders
circadian
rhythm
disruption
are
imprecise,
laborious,
often
do
not
relate
well
key
clinical
health
outcomes.
Newer
emerging
that
aim
overcome
the
practical
technical
constraints
of
current
metrics
have
considerable
potential
better
explain
disorder
pathophysiology
thus
more
precisely
align
diagnostic,
treatment
management
underlying
pathology.
These
include
fine-grained
continuous
EEG
signal
feature
detection
novel
oxygenation
encapsulate
hypoxia
duration,
frequency,
magnitude
readily
possible
via
advanced
data
acquisition
scoring
algorithm
approaches.
Recent
technological
advances
may
also
soon
facilitate
simple
assessment
physiology
at
home
enable
diagnostics
even
for
“non-circadian
rhythm”
disorders,
such
as
chronic
insomnia
apnea,
which
in
many
cases
a
component.
Bringing
these
into
clinic
settings
should
be
priority
field.
Modern
tracking
technology
can
further
transition
from
laboratory
home,
where
environmental
factors
noise
light
could
usefully
inform
decision-making.
The
“endpoint”
new
assessments
will
targeted
therapies
directly
address
an
individualized,
precision
medicine
approach.
This
review
outlines
state-of-the-art
monitoring
covers
several
define
its
consequences.
Current Opinion in Systems Biology,
Journal Year:
2024,
Volume and Issue:
37, P. 100506 - 100506
Published: Feb. 29, 2024
The
growing
numbers
of
cancer
cases
represent
a
medical
and
societal
burden
worldwide.
More
than
half
all
patients
are
treated
with
chemotherapy.
Yet,
chemotherapeutic
drugs
kill
not
only
cells,
but
also
healthy
tissue,
causing
massive
adverse
side
effects.
Recent
research
on
circadian
medicine
suggests
that
side-effects
can
be
reduced,
treatment
efficacy
increased,
by
considering
the
biological
clock
patients.
Integrating
profiles
molecular
markers
in
personalized
mathematical
models
simulate
individual
dynamics
drug
uptake,
action
cellular
response
to
This
requires
advanced
computational
tools
balance
prediction
quality
overfitting.
Personalized
will
eventually
lead
an
optimal
alignment
timing
inner
patient,
reducing
effects,
increasing
enhancing
patient
well-being.
Circulation Research,
Journal Year:
2024,
Volume and Issue:
134(6), P. 727 - 747
Published: March 14, 2024
The
blood-brain
barrier
(BBB)
is
a
critical
interface
separating
the
central
nervous
system
from
peripheral
circulation,
ensuring
brain
homeostasis
and
function.
Recent
research
has
unveiled
profound
connection
between
BBB
circadian
rhythms,
endogenous
oscillations
synchronizing
biological
processes
with
24-hour
light-dark
cycle.
This
review
explores
significance
of
rhythms
in
context
functions,
an
emphasis
on
substrate
passage
through
BBB.
Our
discussion
includes
efflux
transporters
molecular
timing
mechanisms
that
regulate
their
activities.
A
significant
focus
this
potential
implications
chronotherapy,
leveraging
our
knowledge
for
improving
drug
delivery
to
brain.
Understanding
temporal
changes
can
lead
optimized
administration,
enhance
therapeutic
efficacy
neurological
disorders
while
reducing
side
effects.
By
elucidating
interplay
transport
across
BBB,
offers
insights
into
innovative
interventions.
Aging and Disease,
Journal Year:
2025,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2025
Circadian
rhythm
is
the
internal
homeostatic
physiological
clock
that
regulates
24-hour
sleep/wake
cycle.
This
biological
helps
to
adapt
environmental
changes
such
as
light,
dark,
temperature,
and
behaviors.
Aging,
on
other
hand,
a
process
of
results
in
progressive
decline
cells,
tissues,
vital
systems
body.
Both
aging
circadian
are
highly
interlinked
phenomena
with
bidirectional
relationship.
The
leads
disruptions
while
dysfunctional
rhythms
promote
age-related
complications.
processes
involve
diverse
physiological,
molecular,
cellular
modifications
DNA
repair
mechanisms,
ROS
generation,
apoptosis,
cell
proliferation.
review
aims
examine
role
context
lung
cancer.
will
also
existing
literature
vice
versa.
Various
molecular
pathways
genes
BMAL1,
SIRT1,
HLF,
PER1
their
implications
aging,
rhythms,
cancer
be
discussed.
JCO Precision Oncology,
Journal Year:
2025,
Volume and Issue:
9
Published: Jan. 1, 2025
PURPOSE
Chronoradiobiology
has
emerged
as
a
potential
field
of
study
with
therapeutic
implications
for
cancer
treatment.
We
aimed
to
investigate
the
association
between
radiation
chronotherapy
and
efficacy
toxicity
patients
nasopharyngeal
carcinoma
(NPC).
PATIENTS
AND
METHODS
Patients
nonmetastatic
NPC
treated
intensity-modulated
radiotherapy
in
Fujian
Cancer
Hospital
January
2017
December
2019
were
included.
Propensity
score
matching
(PSM)
1:1:1
was
used
account
selection
bias.
Cox
regression
analysis
performed
explore
impact
timing
on
patient
survival.
Sensitivity
implemented
determine
size
directional
stability.
RESULTS
One
thousand
forty
met
inclusion
criteria
332
included
PSM
cohort.
In
unmatched
cohort
analysis,
morning
exhibited
significantly
superior
overall
survival
(OS)
outcome
(hazard
ratio
[HR],
0.60
[95%
CI,
0.40
0.91],
adjusted
log-rank
P
=
.028)
than
afternoon
one.
After
it
observed
that
individuals
undergoing
group
(HR,
5.88
2.55
13.58],
.004)
night
4.81
1.91
12.11],
.018)
displayed
tendency
toward
shorter
OS
compared
group.
No
significant
differences
acute
treatment-related
adverse
effects
among
three
groups.
Morning
demonstrated
consistent
robustness
multivariable
thereby
establishing
an
higher
OS.
The
directionality
effect
across
sensitivity
analysis.
CONCLUSION
These
results
underscore
benefits
scheduling
management,
although
prospective
studies
are
needed
confirm
these
findings.
