Journal of Molecular Biology, Journal Year: 2025, Volume and Issue: unknown, P. 169115 - 169115
Published: March 1, 2025
Language: Английский
ChemBioChem, Journal Year: 2024, Volume and Issue: 25(10)
Published: March 29, 2024
Abstract Peptides have become an indispensable tool in engineering of multifunctional nanostructure platforms for biomedical applications such as targeted drug and gene delivery, imaging biosensing. They can be covalently incorporated into a variety nanoparticles (NPs) including polymers, metallic nanoparticles, others. Using different bioconjugation techniques, peptide‐modified NPs formulated to produce therapeutical diagnostic offering high specificity, lower toxicity, biocompatibility, stimuli responsive behavior. Targeting peptides direct the specific tissues delivery due their specificity towards certain receptors. Furthermore, stimuli‐responsive features, they offer controlled release therapeutics desired sites disease. In addition, peptide‐based biosensors agents provide non‐invasive detection monitoring diseases cancer, infectious diseases, neurological disorders. this review, we covered design formulation recent NP platforms, well utilization vitro vivo targeting, sensing, applications. end, provided future outlook new peptide conjugated nanomaterials
Language: Английский
Citations
15
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 240 - 240
Published: Feb. 6, 2024
Effective drug delivery is essential for cancer treatment. Drug systems, which can be tailored to targeted transport and integrated tumor therapy, are vital in improving the efficiency of Peptides play a significant role various biological physiological functions offer high design flexibility, excellent biocompatibility, adjustable morphology, biodegradability, making them promising candidates delivery. This paper reviews peptide-mediated focusing on self-assembled peptides peptide–drug conjugates. It discusses mechanisms structural control peptides, varieties roles conjugates, strategies augment peptide stability. The review concludes by addressing challenges future directions.
Language: Английский
Citations
11
3 Biotech, Journal Year: 2024, Volume and Issue: 14(4)
Published: March 18, 2024
Language: Английский
Citations
11
Medicinal Research Reviews, Journal Year: 2024, Volume and Issue: 44(6), P. 2420 - 2471
Published: May 5, 2024
The development of peptide drugs has made tremendous progress in the past few decades because advancements modification chemistry and analytical technologies. novel-designed have been modified through various biochemical methods with improved diagnostic, therapeutic, drug-delivery strategies. Researchers found it a helping hand to overcome inherent limitations peptides bring continued their applications. Furthermore, emergence peptide-drug conjugates (PDCs)-utilizes target-oriented moieties as vehicle for cytotoxic payloads via conjugation cleavable chemical agents, resulting key foundation new era targeted drugs. This review summarizes classifications drugs, suitable strategies improve ADME (adsorption, distribution, metabolism, excretion) features recent (2015-early 2024) progress/achievements peptide-based drug delivery systems well fruitful implication preclinical clinical studies. we also summarized brief description other types PDCs, including peptide-MOF peptide-UCNP conjugates. principal aim is provide scattered diversified knowledge one place help researchers understand pinching knots science PDC toward bright future novel
Language: Английский
Citations
11
Current Medical Research and Opinion, Journal Year: 2024, Volume and Issue: 40(11), P. 1943 - 1961
Published: Oct. 16, 2024
The development of therapies followed a generalized approach for long time, assuming that single treatment could effectively address various patient populations. However, recent breakthroughs have revealed the limitations this one-size-fits-all paradigm. More recently, field therapeutics has witnessed shift toward other modules, including cell therapies, high molecular weight remedies, personalized medicines, and gene therapies. Such advancements in therapeutic modules potential to revolutionize healthcare pave way medicines are more efficient with minimal side effects. Cell gained considerable attention regenerative medicine. Stem cell-based instance, hold promise tissue repair regeneration, ongoing research focusing on enhancing their efficacy safety. High drugs like peptides proteins emerged as promising because specificity diverse biological functions. Engineered developed targeted drug delivery, immunotherapy, disease-modulation. In medicine, tailored treatments individuals based specific genetic profiling, lifestyle, biomarkers, disease characteristics all implemented. Clinicians optimize outcomes minimize adverse effects, using mutations, yielding remarkable results. Gene revolutionized disorders by directly targeting underlying abnormalities. Innovative techniques, such CRISPR-Cas9 allowed precise editing, opening up possibilities curing previously incurable conditions. conclusion,
Language: Английский
Citations
11
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7264 - 7264
Published: July 1, 2024
Cancer is one of the leading causes morbidity and death worldwide, making it a serious global health concern. Chemotherapy, radiotherapy, surgical treatment are most used conventional therapeutic approaches, although they show several side effects that limit their effectiveness. For these reasons, discovery new effective alternative therapies still represents an enormous challenge for tumour diseases. Recently, anticancer peptides (ACPs) have gained attention cancer diagnosis treatment. ACPs small bioactive molecules which selectively induce cell through variety mechanisms such as apoptosis, membrane disruption, DNA damage, immunomodulation, well inhibition angiogenesis, survival, proliferation pathways. can also be employed targeted delivery drugs into cells. With over 1000 clinical trials using ACPs, potential application in therapy seems promising. Peptides utilized conjunction with imaging agents molecular methods, MRI, PET, CT, NIR, improving detection classification cancer, monitoring response. In this review we will provide overview biological activity some natural synthetic common malignant tumours affecting people around world.
Language: Английский
Citations
10
Peptide Science, Journal Year: 2024, Volume and Issue: 116(4)
Published: Feb. 1, 2024
Abstract In the realm of therapeutic peptides, tremendous progress has been achieved in last two decades. The building block peptides that is, ‘Amino Acid’ modified by various chemical modifications such as side‐chain alteration linear cyclization, back‐bone modification, pro‐drug moiety, conjugation with heterocycles, and natural products to make a foremost candidate drug. Since advent insulin 1922, have immensely affected development pharmaceutical industry giving rise peptide‐based drug industry. recent years, having antimicrobial, antiviral, anti‐tumor, anti‐inflammatory, anti‐aging, antioxidant properties developed. Also, it now entered potent field oncology also become valuable tool radiolabeled peptide for detection diseases. Generally, were extracted from sources olden days, but presently work is directed towards finding alternate sustainable ways developing synthetic peptides. present review covers discussion about historic evaluation available effective processes, current advancements, use bioinformatic tools, computational strategies, methodology overcome barrier making future world.
Language: Английский
Citations
9
Heliyon, Journal Year: 2024, Volume and Issue: 10(22), P. e40265 - e40265
Published: Nov. 1, 2024
Due to the spread of antibiotic resistance, global attention is focused on its inhibition and expansion effective medicinal compounds. The novel functional properties peptides have opened up new horizons in personalized medicine. With artificial intelligence methods combined with therapeutic peptide products, pharmaceuticals biotechnology advance drug development rapidly reduce costs. Short-chain inhibit a wide range pathogens great potential for targeting diseases. To address challenges synthesis sustainability, methods, namely machine learning, must be integrated into their production. Learning can use complicated computations select active toxic compounds metabolic activity. Through this comprehensive review, we investigated method as tool finding peptide-based drugs providing more accurate analysis through introduction predictable databases selection development.
Language: Английский
Citations
9
Nanomaterials, Journal Year: 2023, Volume and Issue: 13(17), P. 2476 - 2476
Published: Sept. 1, 2023
Breast cancer represents the most common type and one of major leading causes death in female worldwide population. Overexpression HER2, a transmembrane glycoprotein related to epidermal growth factor receptor, results biologically clinically aggressive breast subtype. It is also primary driver for tumor detection progression and, addition being an important prognostic women diagnosed with cancer, HER2 widely known therapeutic target drug development. The aim this review provide updated overview main approaches diagnosis treatment HER2-positive proposed literature over past decade. We focused on different targeting strategies involving antibodies peptides that have been explored their relative outcomes current limitations need be improved. encompasses discussion targeted acting as probes molecular imaging. By using types HER2-targeting strategies, nanotechnology promises overcome some clinical challenges by developing novel HER2-guided nanosystems suitable powerful tools imaging, targeting, therapy.
Language: Английский
Citations
20
Nanoscale Horizons, Journal Year: 2023, Volume and Issue: 9(1), P. 14 - 43
Published: Sept. 13, 2023
Discussion on how to overcome the current failures of synthetic and cell-derived nanomaterials bypass or temporally open tight junctions brain eye using recent advancements in various nanotechnological strategies.
Language: Английский
Citations
18