Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)
Published: Dec. 19, 2024
Language: Английский
Cancers, Journal Year: 2024, Volume and Issue: 16(3), P. 512 - 512
Published: Jan. 24, 2024
Iron (Fe) and copper (Cu), essential transition metals, play pivotal roles in various cellular processes critical to cancer biology, including cell proliferation, mitochondrial respiration, distant metastases, oxidative stress. The emergence of ferroptosis cuproptosis as distinct forms non-apoptotic death has heightened their significance, particularly connection with these metal ions. While initially studied separately, recent evidence underscores the interdependence cuproptosis. Studies reveal a link between accumulation induction. This interconnected relationship presents promising strategy, especially for addressing refractory cancers marked by drug tolerance. Harnessing toxicity iron clinical settings becomes crucial. Simultaneous targeting cuproptosis, exemplified combination sorafenib elesclomol-Cu, represents an intriguing approach. Strategies mitochondria further enhance precision approaches, providing hope improving treatment outcomes drug-resistant cancers. Moreover, chelators copper-lowering agents established therapeutic modalities exhibits synergy that holds promise augmentation anti-tumor efficacy malignancies. review elaborates on complex interplay underlying mechanisms, explores potential druggable targets both research settings.
Language: Английский
Citations
24
BMEMat, Journal Year: 2024, Volume and Issue: unknown
Published: March 4, 2024
Abstract Nanomedicine‐assisted sonodynamic therapy (SDT) has emerged as one of the most promising cancer therapies due to its unique advantages high penetration, non‐radiation, and excellent oxidative stress effect, but always suffered from self‐protection mechanism apoptosis resistance characteristics evolutionarily mutated cells. Regulated cell death (RCD) received increasing attention in precision treatments because significant role synergistically sensitizing reversing immunosuppressive microenvironment during SDT nanomedicine‐triggered immunogenic death. Herein, paradigmatic research RCD‐augmented tumor immunotherapeutics are typically introduced, such autophagy blockade, ferroptosis targeting, pyroptosis induction, necroptosis initiation, cuproptosis actuation, PANoptosis trigger, coordinated anti‐tumor mechanisms discussed detail. Multiple analysis focusing on currently unsolved problems future development prospects RCD‐based nano‐oncology medicine also prospected further strengthen expand scope therapeutic applications.
Language: Английский
Citations
16
Human Cell, Journal Year: 2025, Volume and Issue: 38(2)
Published: Jan. 3, 2025
Language: Английский
Citations
1
Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)
Published: Feb. 10, 2024
Abstract Background Cuproptosis-related genes (CRGs) are associated with lung adenocarcinoma. However, the links between CRGs and non-small-cell cancer (NSCLC) not clear. In this study, we aimed to develop two cuproptosis models investigate their correlation NSCLC in terms of clinical features tumor microenvironment. Methods CRG expression profiles data from normal tissues was obtained GEO (GSE42127) TCGA datasets. Molecular clusters were classified into three patterns based on cluster-related specific differentially expressed (CRDEGs). Then, established. First, a prognostic score model CRDEGs established using univariate/multivariate Cox analysis. through principal component analysis, prognosis-related acquired via univariate analysis CRDEGs. patients divided high/low risk groups. Results Eighteen acquired, all upregulated tissues, 15 which significantly ( P < 0.05). Among clusters, cluster B had best prognosis. CRDEG C survival. model, high-risk group worse prognosis, higher mutation load, lower immune infiltration while high represented better survival, high-level infiltration. Conclusions The may be prognosis These novel findings progression landscape facilitate provision more personalized immunotherapy interventions for patients.
Language: Английский
Citations
4
Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15
Published: Dec. 19, 2023
Copper (Cu) plays a crucial role as trace element in various physiological processes humans. Nonetheless, free copper ions accumulate the brain over time, resulting range of pathological changes. Compelling evidence indicates that excessive deposition contributes to cognitive decline individuals with Alzheimer’s disease (AD). Free levels serum and AD patients are notably elevated, leading reduced antioxidant defenses mitochondrial dysfunction. Moreover, accumulation triggers specific form cell death, namely copper-dependent death (cuproptosis). This article aimed review correlation between dysregulation pathogenesis AD, along primary pathways regulating homoeostasis copper-induced AD. Additionally, efficacy safety natural synthetic agents, including chelators, lipid peroxidation inhibitors, antioxidants, were examined. These treatments can restore equilibrium prevent cases. Another aim this was highlight significance promote development pharmaceutical interventions address it.
Language: Английский
Citations
11
Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown, P. 110324 - 110324
Published: Feb. 1, 2025
Language: Английский
Citations
0
Process Biochemistry, Journal Year: 2024, Volume and Issue: 141, P. 19 - 29
Published: March 6, 2024
Language: Английский
Citations
3
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: May 26, 2024
Abstract Purpose This study aimed to construct an m6A and cuproptosis-related long non-coding RNAs (lncRNAs) signature accurately predict the prognosis of kidney clear cell carcinoma (KIRC) patients using information acquired from The Cancer Genome Atlas (TCGA) database. Methods First, co-expression analysis was performed identify lncRNAs linked with N6-methyladenosine (m6A) cuproptosis in ccRCC. Then, a model encompassing four candidate constructed via univariate, least absolute shrinkage together selection operator (LASSO), multivariate regression analyses. Furthermore, Kaplan–Meier, principal component, functional enrichment annotation, nomogram analyses were develop risk that could effectively assess medical outcomes for ccRCC cases. Moreover, cellular function NFE4 Caki-1/OS-RC-2 cultures elucidated through CCK-8/EdU assessments Transwell experiments. Dataset indicated can have possible implications cuproptosis, may promote progression. Results We panel prognostic prediction model. Kaplan–Meier ROC curves showed feature had acceptable predictive validity TCGA training, test, complete groups. lncRNA higher diagnostic efficiency than other clinical features. gene associated It also revealed proliferation migration Caki-1 /OS-RC-2 cells inhibited knockdown group. Conclusion Overall, this our potential value.
Language: Английский
Citations
3
Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(13)
Published: July 1, 2024
Abstract Cuproptosis plays an important role in cancer, but its lung cancer remains unknown. Transcriptional profiles, clinical details and mutation data were acquired from the Cancer Genome Atlas database through a variety of methods. The analysis this publicly available was comprehensively performed using R software along with relevant packages, ensuring thorough examination information. In study, we conducted detailed cuproptosis‐related genes lncRNA co‐expression, identifying 129 lncRNAs establishing prognostic model four key (LINC00996, RPARP‐AS1, SND1‐IT1, TMPO‐AS1). Utilizing TCGA GEO databases, effectively categorized patients into high‐ low‐risk groups, showing significant survival differences. Correlation highlighted specific relationships between individual cuproptosis genes. Our indicated higher rate group across various cohorts. Additionally, model's predictive accuracy confirmed independent ROC curve evaluations. Functional enrichment revealed distinct biological pathways immune functions risk groups. Tumour load differentiated groups by their profiles. Drug sensitivity infiltration studies CIBERSORT algorithm further elucidated potential treatment responses different This comprehensive evaluation underscores significance as biomarkers for prognosis microenvironment.
Language: Английский
Citations
3
Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(3), P. 2687 - 2699
Published: July 18, 2024
Language: Английский
Citations
3