Cuproptosis: a promising new target for breast cancer therapy DOI Creative Commons
Qianqian Jiang, Fei Tong, Yun Xu

et al.

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 19, 2024

Language: Английский

Interplay of Ferroptosis and Cuproptosis in Cancer: Dissecting Metal-Driven Mechanisms for Therapeutic Potentials DOI Open Access
Jinjiang Wang, Jiaxi Li, Jiao Liu

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(3), P. 512 - 512

Published: Jan. 24, 2024

Iron (Fe) and copper (Cu), essential transition metals, play pivotal roles in various cellular processes critical to cancer biology, including cell proliferation, mitochondrial respiration, distant metastases, oxidative stress. The emergence of ferroptosis cuproptosis as distinct forms non-apoptotic death has heightened their significance, particularly connection with these metal ions. While initially studied separately, recent evidence underscores the interdependence cuproptosis. Studies reveal a link between accumulation induction. This interconnected relationship presents promising strategy, especially for addressing refractory cancers marked by drug tolerance. Harnessing toxicity iron clinical settings becomes crucial. Simultaneous targeting cuproptosis, exemplified combination sorafenib elesclomol-Cu, represents an intriguing approach. Strategies mitochondria further enhance precision approaches, providing hope improving treatment outcomes drug-resistant cancers. Moreover, chelators copper-lowering agents established therapeutic modalities exhibits synergy that holds promise augmentation anti-tumor efficacy malignancies. review elaborates on complex interplay underlying mechanisms, explores potential druggable targets both research settings.

Language: Английский

Citations

24

Regulated cell death‐amplified sonodynamic anti‐tumor immune nanotherapeutics DOI Creative Commons
Liqiang Zhou, Yangmengfan Chen, Dong Xie

et al.

BMEMat, Journal Year: 2024, Volume and Issue: unknown

Published: March 4, 2024

Abstract Nanomedicine‐assisted sonodynamic therapy (SDT) has emerged as one of the most promising cancer therapies due to its unique advantages high penetration, non‐radiation, and excellent oxidative stress effect, but always suffered from self‐protection mechanism apoptosis resistance characteristics evolutionarily mutated cells. Regulated cell death (RCD) received increasing attention in precision treatments because significant role synergistically sensitizing reversing immunosuppressive microenvironment during SDT nanomedicine‐triggered immunogenic death. Herein, paradigmatic research RCD‐augmented tumor immunotherapeutics are typically introduced, such autophagy blockade, ferroptosis targeting, pyroptosis induction, necroptosis initiation, cuproptosis actuation, PANoptosis trigger, coordinated anti‐tumor mechanisms discussed detail. Multiple analysis focusing on currently unsolved problems future development prospects RCD‐based nano‐oncology medicine also prospected further strengthen expand scope therapeutic applications.

Language: Английский

Citations

16

Taxifolin regulates SLC31A1-mediated cuproptosis and tumor progression in hepatocellular carcinoma DOI
Jike Li,

Yuelian Wang,

Lei Bao

et al.

Human Cell, Journal Year: 2025, Volume and Issue: 38(2)

Published: Jan. 3, 2025

Language: Английский

Citations

1

A cuproptosis score model and prognostic score model can evaluate clinical characteristics and immune microenvironment in NSCLC DOI Creative Commons
Yijie Tang, Tianyi Wang, Qixuan Li

et al.

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: Feb. 10, 2024

Abstract Background Cuproptosis-related genes (CRGs) are associated with lung adenocarcinoma. However, the links between CRGs and non-small-cell cancer (NSCLC) not clear. In this study, we aimed to develop two cuproptosis models investigate their correlation NSCLC in terms of clinical features tumor microenvironment. Methods CRG expression profiles data from normal tissues was obtained GEO (GSE42127) TCGA datasets. Molecular clusters were classified into three patterns based on cluster-related specific differentially expressed (CRDEGs). Then, established. First, a prognostic score model CRDEGs established using univariate/multivariate Cox analysis. through principal component analysis, prognosis-related acquired via univariate analysis CRDEGs. patients divided high/low risk groups. Results Eighteen acquired, all upregulated tissues, 15 which significantly ( P < 0.05). Among clusters, cluster B had best prognosis. CRDEG C survival. model, high-risk group worse prognosis, higher mutation load, lower immune infiltration while high represented better survival, high-level infiltration. Conclusions The may be prognosis These novel findings progression landscape facilitate provision more personalized immunotherapy interventions for patients.

Language: Английский

Citations

4

Copper and cuproptosis: new therapeutic approaches for Alzheimer’s disease DOI Creative Commons
Xiao Li, Xinwang Chen, Xiyan Gao

et al.

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: Dec. 19, 2023

Copper (Cu) plays a crucial role as trace element in various physiological processes humans. Nonetheless, free copper ions accumulate the brain over time, resulting range of pathological changes. Compelling evidence indicates that excessive deposition contributes to cognitive decline individuals with Alzheimer’s disease (AD). Free levels serum and AD patients are notably elevated, leading reduced antioxidant defenses mitochondrial dysfunction. Moreover, accumulation triggers specific form cell death, namely copper-dependent death (cuproptosis). This article aimed review correlation between dysregulation pathogenesis AD, along primary pathways regulating homoeostasis copper-induced AD. Additionally, efficacy safety natural synthetic agents, including chelators, lipid peroxidation inhibitors, antioxidants, were examined. These treatments can restore equilibrium prevent cases. Another aim this was highlight significance promote development pharmaceutical interventions address it.

Language: Английский

Citations

11

Cuproptosis Regulation by Long Noncoding RNAs: Mechanistic Insights and Clinical Implications in Cancer DOI

Nahla E. El‐Ashmawy,

Eman G. Khedr, Mariam A. Abo-Saif

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown, P. 110324 - 110324

Published: Feb. 1, 2025

Language: Английский

Citations

0

Fabrication of etoposide-loaded folic-acid-clocked mesoporous nanoparticles: Investigation of lung cancer proliferation and induction of apoptosis and ferroptosis DOI

Wanwan Chen,

Xuezhen Cao,

Songsong Wu

et al.

Process Biochemistry, Journal Year: 2024, Volume and Issue: 141, P. 19 - 29

Published: March 6, 2024

Language: Английский

Citations

3

Bioinformatics analysis and experimental validation of m6A and cuproptosis-related lncRNA NFE4 in clear cell renal cell carcinoma DOI Creative Commons
Rui Feng, Haolin Li, Tong Meng

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 26, 2024

Abstract Purpose This study aimed to construct an m6A and cuproptosis-related long non-coding RNAs (lncRNAs) signature accurately predict the prognosis of kidney clear cell carcinoma (KIRC) patients using information acquired from The Cancer Genome Atlas (TCGA) database. Methods First, co-expression analysis was performed identify lncRNAs linked with N6-methyladenosine (m6A) cuproptosis in ccRCC. Then, a model encompassing four candidate constructed via univariate, least absolute shrinkage together selection operator (LASSO), multivariate regression analyses. Furthermore, Kaplan–Meier, principal component, functional enrichment annotation, nomogram analyses were develop risk that could effectively assess medical outcomes for ccRCC cases. Moreover, cellular function NFE4 Caki-1/OS-RC-2 cultures elucidated through CCK-8/EdU assessments Transwell experiments. Dataset indicated can have possible implications cuproptosis, may promote progression. Results We panel prognostic prediction model. Kaplan–Meier ROC curves showed feature had acceptable predictive validity TCGA training, test, complete groups. lncRNA higher diagnostic efficiency than other clinical features. gene associated It also revealed proliferation migration Caki-1 /OS-RC-2 cells inhibited knockdown group. Conclusion Overall, this our potential value.

Language: Английский

Citations

3

Deciphering the role of cuproptosis‐related lncRNAs in shaping the lung cancer immune microenvironment: A comprehensive prognostic model DOI Creative Commons
Hai Huang,

Guoxi Chen,

Zongqi Zhang

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(13)

Published: July 1, 2024

Abstract Cuproptosis plays an important role in cancer, but its lung cancer remains unknown. Transcriptional profiles, clinical details and mutation data were acquired from the Cancer Genome Atlas database through a variety of methods. The analysis this publicly available was comprehensively performed using R software along with relevant packages, ensuring thorough examination information. In study, we conducted detailed cuproptosis‐related genes lncRNA co‐expression, identifying 129 lncRNAs establishing prognostic model four key (LINC00996, RPARP‐AS1, SND1‐IT1, TMPO‐AS1). Utilizing TCGA GEO databases, effectively categorized patients into high‐ low‐risk groups, showing significant survival differences. Correlation highlighted specific relationships between individual cuproptosis genes. Our indicated higher rate group across various cohorts. Additionally, model's predictive accuracy confirmed independent ROC curve evaluations. Functional enrichment revealed distinct biological pathways immune functions risk groups. Tumour load differentiated groups by their profiles. Drug sensitivity infiltration studies CIBERSORT algorithm further elucidated potential treatment responses different This comprehensive evaluation underscores significance as biomarkers for prognosis microenvironment.

Language: Английский

Citations

3

Quercetin Attenuates Acute Kidney Injury Caused by Cisplatin by Inhibiting Ferroptosis and Cuproptosis DOI

Mengqi Shi,

Youchaou Mobet, Hong C. Shen

et al.

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(3), P. 2687 - 2699

Published: July 18, 2024

Language: Английский

Citations

3