Pharmacological Activities, Therapeutic Effects, and Mechanistic Actions of Trigonelline

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3385 - 3385

Published: March 16, 2024

Trigonelline (TRG) is a natural polar hydrophilic alkaloid that found in many plants such as green coffee beans and fenugreek seeds. TRG potentially acts on multiple molecular targets, including nuclear factor erythroid 2-related 2 (Nrf2), peroxisome proliferator-activated receptor γ, glycogen synthase kinase, tyrosinase, nerve growth factor, estrogen receptor, amyloid-β peptide, several neurotransmitter receptors. In this review, we systematically summarize the pharmacological activities, medicinal properties, mechanistic actions of potential therapeutic agent. Mechanistically, can facilitate maintenance restoration metabolic homeostasis glucose lipids. It counteract inflammatory constituents at levels by hampering pro-inflammatory release, alleviating propagation, attenuating tissue injury. concurrently modulates oxidative stress blockage detrimental Nrf2 pathway when autophagy impaired. Therefore, it exerts diverse effects variety pathological conditions associated with chronic diseases age-related disorders. shows multidimensional effects, neuroprotection from neurodegenerative disorders diabetic peripheral neuropathy, neuromodulation, mitigation cardiovascular disorders, skin diseases, mellitus, liver kidney injuries, anti-pathogen anti-tumor activities. Further validations are required to define its specific targeting molecules, dissect underlying networks, corroborate efficacy clinical trials.

Language: Английский

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Development and validation of an eco-friendly, stability-indicating UV spectroscopic method for trigonelline analysis in nanoformulation using quality by design approach

Analytical Chemistry Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: Jan. 8, 2025

Language: Английский

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Coffee and Alzheimer's disease

Progress in brain research, Journal Year: 2024, Volume and Issue: unknown, P. 21 - 55

Published: Jan. 1, 2024

Language: Английский

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Trigonelline as an anticonvulsant agent: mechanistic insights into NMDA receptor expression and oxidative stress balance

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 20, 2024

Abstract Glutamatergic neurotransmission and oxidative stress are involved in the pathophysiology of seizures. Some anticonvulsants exert their effects through modulation these pathways. Trigonelline (TRG) has been shown to possess various pharmacological like neuroprotection. Therefore, this study was performed determine TRG’s anticonvulsant effects, focusing on its potential N-methyl-D-aspartate (NMDA) receptors, a type glutamate receptor, state prefrontal cortex (PFC) PTZ-induced seizure mice. Seventy-two male mice were randomly divided into nine groups. The groups included that received normal saline, TRG at doses 10, 50, 100 mg/kg, diazepam, NMDA (an agonist), ketamine antagonist), effective dose with NMDA, as well sub-effective ketamine, respectively. All agents administrated intraperitoneally 60 min before induction seizures by PTZ. Latency seizure, total antioxidant capacity (TAC), malondialdehyde (MDA) levels serum PFC measured. Furthermore, gene expression NR2A NR2B, subunits measured PFC. administration increased latency onset enhanced TAC while reducing MDA both serum. also decreased NR2B Unexpectedly, findings revealed concurrent amplified, whereas mitigated, impact seizure. diminished positive stress, amplified beneficial indicating complex interaction between receptor modulation. In results showed significantly when co-administrated TRG. It found that, least partially, effect mediated attenuation glutamatergic reduction stress.

Language: Английский

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Molecular Docking Analysis Reveals the Promising Role of Apigenin as a Potential Treatment for Neurological Disorders

Clinical Neuropharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Objectives Neurological disorders represent a significant global health challenge, necessitating the exploration of novel therapeutic agents. Apigenin, natural flavonoid abundantly found in various plants, has garnered attention for its potential neuroprotective properties. In this study, we employed molecular docking simulations to investigate interaction between apigenin and key targets associated with neurological disorders. Methods The analysis focused on receptors implicated neuroinflammation, oxidative stress, neurotransmission regulation. Results Our results reveal high binding affinity towards critical targets, including GABA, mACh, nACh, NMDA, 5HTA, AMPA, insulin, dopamine receptors. findings suggest that may exert effects through multifaceted mechanisms, anti-inflammatory, antioxidant, regulatory pathways. Additionally, absence adverse poses emphasizes safety profile apigenin. Conclusions This study provides valuable insights into role mitigating pathways Further vitro vivo investigations are warranted validate elucidate mechanisms apigenin, paving way development as promising treatment option conditions.

Language: Английский

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Safranal’s Neurological Nexus: Unveiling Therapeutic Potential through Molecular Docking

Neurochemical Journal, Journal Year: 2024, Volume and Issue: 18(3), P. 469 - 482

Published: Sept. 1, 2024

Language: Английский

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A Systematic Review on the Effectiveness of Trigonelline, Safranal and Chamomile in Cure and Prevention of Alzheimer’s Disease and Dementia

Neurochemical Journal, Journal Year: 2024, Volume and Issue: 18(3), P. 415 - 433

Published: Sept. 1, 2024

Language: Английский

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