Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102504 - 102504
Published: Sept. 1, 2024
Language: Английский
Sclerosis, Journal Year: 2025, Volume and Issue: 3(1), P. 8 - 8
Published: March 5, 2025
Background/Objectives: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive degeneration of motor neurons. The gut microbiota, community microorganisms in digestive tract, has recently been implicated ALS pathogenesis through its influence on neuroinflammation and metabolic pathways. This review explores potential role microbiota metabolites progression investigates therapeutic approaches targeting microbiota. Methods: A comprehensive current literature was conducted to assess relationship between composition, microbial metabolites, patients. We searched for published reports ALS, emphasizing complex interplay dysbiosis, neuroinflammation, systemic metabolism. Special emphasis placed studies exploring short-chain fatty acids (SCFAs), bacterial amyloids (curli-like factors), neurotoxins such as β-methylamino-L-alanine (BMAA). liver–gut axis evaluated well. changes would sustain rationale strategies probiotics, prebiotics, fecal transplantation (FMT), dietary interventions. Results: patients exhibit reduced SCFA-producing bacteria an increase potentially pathogenic genera. Of note, different do not agree common patterns being linked supporting need further, more extensive studies. Dysbiosis sometimes correlates with inflammation disrupted liver function, amplifying neuroinflammatory responses. Key including SCFAs, amyloids, BMAA, may exacerbate neuron promoting protein misfolding, oxidative stress, neuroinflammation. Emerging strategies, probiotics FMT, show restoring balance, although clinical data remain limited. Conclusions: could modulate metabolism ALS. Microbiota-targeted therapies, interventions, represent promising avenues mitigating disease progression. Further research required validate these interventions large-scale, longitudinal develop personalized microbiota-based treatments tailored individual phenotypes.
Language: Английский
Citations
1
Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 393 - 393
Published: March 27, 2025
Background: Autophagy, a catabolic process essential for maintaining cellular homeostasis, declines with age and unhealthy lifestyles, contributing to neurodegenerative diseases. Probiotics, including Milmed yeast, have demonstrated anti-inflammatory antioxidant properties. This study evaluated the activity of on BV-2 microglial cells in vitro vivo model Caenorhabditis elegans (C. elegans) restoring autophagic processes. Methods: were incubated S. cerevisiae (Milmed treated yeast or untreated yeast) then stimulated lipopolysaccharide (LPS). mRNAs factors enzymes assessed by qPCR; mTOR NRF2 ELISA. pNRF2 compared cytosolic was immunofluorescence. The longevity, body size, reactive oxygen species (ROS) levels C. measured fluorescence microscopy. Results: Treatment YPD cultured dried powder obtained from it promoted flux, as shown increased expression Beclin-1, ATG7, LC3, p62 inhibition mTOR, It also enhanced response increasing NRF2, SOD1, GPX; moreover, enhanced, dietary supplementation prolonged survival reduced age-related ROS accumulation without changing gst-4. pro-longevity effect found be dependent SKN-1/Nrf2 activation, absence benefit skn-1 mutants. Conclusions: demonstrates significant pro-autophagy effects elegans, thereby extending lifespan improving stress resistance, which, together previously activity, highlights its role highly effective probiotic beneficial health effects. Activation SKN-1/NRF2 pathway modulation autophagy support therapeutic potential neuroprotection healthy aging.
Language: Английский
Citations
1
Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3689 - 3689
Published: Oct. 29, 2024
The intestinal microbiota is a complex ecosystem where the microbial community (including bacteria) can metabolize available substrates via metabolic pathways specific to each species, often related in symbiotic relations. As consequence of using and growth, beneficial metabolites be produced. When this reflects health benefits for host, these categorized as prebiotics. Given that most prebiotic candidates must have low molecular weight further metabolized by microbiota, role preliminary biological pretreatment crucial. To provide proper strategy could decrease complexity polysaccharides reduce levels polymerization target molecules, driving better solubilization consequent use bacteria. high pectin degraded (partially depolymerized), its solubility increases, thereby improving utilization gut microbiota. With regards application, prebiotics well-documented advantages when applied food additives, they improve enhance drug effects, all shown vitro, vivo, clinical trials. In review, we aim systematic evidence mechanisms action modulation pectin-derived oligosaccharides produced decreasing overall after physical and/or chemical treatments compare with other types
Language: Английский
Citations
6
Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 105990 - 105990
Published: Dec. 1, 2024
The rising prevalence of treatment-resistant neuropsychiatric disorders underscores the need for innovative and effective treatment strategies. gut microbiota (GM) plays a pivotal role in progression these diseases, influencing brain mental health through gut-brain axis (GBA). vagus nerve significant GBA, making it key area focus potential novel therapeutic interventions. Vagus stimulation (VNS) was introduced approved as refractory forms some neuropsychological disorders, such depression epilepsy. Considering its impact on several regions that play vital part mood, motivation, affection, cognitive function, VNS has shown treating variety disorders. Harnessing to target bidirectional communication pathways linking GM VN could present an exciting approach Imbalances GM, dysbiosis, can impair between brain, contributing development shows modulating interconnected systems, helping restore balance. Interestingly, composition may also influence effectiveness VNS, modify brain's response this approach. This study provides comprehensive analysis relatively unexplored but noteworthy interaction In addition, we discussed mechanisms, potential, clinical implications GBA across
Language: Английский
Citations
5
The Journal of Nutritional Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 109904 - 109904
Published: March 1, 2025
Language: Английский
Citations
0
BMC Bioinformatics, Journal Year: 2025, Volume and Issue: 26(1)
Published: March 27, 2025
Abstract Background Understanding the metabolic activities of gut microbiome is vital for deciphering its impact on human health. While direct measurement these metabolites through metabolomics effective, it often expensive and time-consuming. In contrast, microbial composition data obtained sequencing more accessible, making a promising resource predicting metabolite profiles. However, current computational models frequently face challenges related to limited prediction accuracy, generalizability, interpretability. Method Here, we present Deep Mixture Variational Gaussian Process Experts (DMoVGPE) model, designed overcome issues. DMoVGPE utilizes dynamic gating mechanism, implemented neural network with fully connected layers dropout regularization, select most relevant experts. During training, refines expert selection, dynamically adjusting their contribution based input features. The model also incorporates an Automatic Relevance Determination (ARD) which assigns relevance scores features by evaluating predictive power. Features linked profiles are given smaller length scales increase influence, while irrelevant down-weighted larger scales, improving both accuracy Conclusions Through extensive evaluations various datasets, consistently achieves higher performance than existing models. Furthermore, our reveals significant associations between specific taxa metabolites, aligning well findings from studies. These results highlight DMoVGPE’s potential provide accurate predictions uncover biologically meaningful relationships, paving way application in disease research personalized healthcare strategies.
Language: Английский
Citations
0
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102504 - 102504
Published: Sept. 1, 2024
Language: Английский
Citations
1