Asian Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: Nov. 26, 2022
Abstract
In
multicomponent
reactions,
three
or
more
reactants
combine
in
one
pot
to
form
a
product
without
the
isolation
of
intermediate
and
most
contribute
newly
formed
reducing
number
steps
involved
waste
generated.
Molecular
iodine
is
mild,
efficient,
relatively
nontoxic,
inexpensive,
commercially
available,
catalyzes
various
organic
reactions
due
its
Lewis
acidic
behaviour.
The
development
catalyzed
by
molecular
indeed
good
green
alternative
for
synthetic
chemistry.
aim
this
article
review
all
important
reported
since
2013
order
envisage
some
new
efficient
protocols
synthesis
structurally
complex
molecules.
Anti-Cancer Agents in Medicinal Chemistry,
Journal Year:
2022,
Volume and Issue:
22(19), P. 3291 - 3303
Published: June 15, 2022
Heterocyclic
compounds
are
that
type
of
substances
deeply
intertwined
with
biological
processes.
Heterocycles
found
in
about
90%
commercially
available
medicines.
In
medicinal
chemistry,
finding
new
synthetic
molecules
drug-like
characteristics
is
a
regular
problem,
which
triggered
the
development
pharmacological
molecules,
majority
based
on
N-heterocyclic
motifs.
Among
heterocycles,
pyrrole
scaffold
most
commonly
heterocycle
both
natural
and
bioactive
compounds.
Pyrrole
has
fivemembered
heterocyclic
ring
plethora
pharmacophores,
resulting
library
different
lead
derivatives
physiologically
active
can
be
used
as
scaffolds
for
antibacterial,
antiviral,
anticancer,
antitubercular,
anti-inflammatory,
enzyme
inhibitors.
On
account
their
extensive
profile,
its
various
have
drawn
much
attention
from
researchers
to
explore
it
benefit
humankind.
This
review
presents
an
overview
recent
developments
against
multiple
therapeutic
targets.
Chemical Biology & Drug Design,
Journal Year:
2022,
Volume and Issue:
100(5), P. 682 - 698
Published: Sept. 5, 2022
Histone-modifying
enzymes
are
the
key
regulators
involved
in
post-translational
modification
of
histone
and
non-histone.
These
responsible
for
epigenetic
control
cellular
functions.
However,
deregulation
activity
these
results
uncontrolled
disorders
such
as
cancer
inflammatory
neurological
diseases.
The
study
includes
acetyltransferases,
deacetylases,
methyl
transferases,
demethylases,
DNA
their
potent
inhibitors
which
a
clinical
trial
used
medicinal
drugs.
present
review
covers
heterocycles
target-specific
histone-modifying
enzyme,
more
specifically
acetyltransferases.
This
also
confers
recent
reports
on
potential
HAT
covered
from
2016
to
2022
future
perspectives
therapy.
Arabian Journal of Chemistry,
Journal Year:
2022,
Volume and Issue:
15(11), P. 104242 - 104242
Published: Sept. 13, 2022
Human
immunodeficiency
virus
(HIV)
especially
HIV-1
infection
and
its
progression
to
acquired
immune
deficiency
syndrome
(AIDS)
remains
a
significant
global
health
challenge.
The
advent
of
the
highly
active
antiretroviral
therapy
(HAART)
has
greatly
extended
life
expectancy
patients
living
with
HIV,
but
it
become
evident
that
long-term
HAART
will
not
eliminate
HIV
reservoir
cure
infection.
Moreover,
drug
resistance
undesirable
side
effects
hamper
efficacious
therapy,
creating
an
urgent
need
develop
novel,
more
effective
less
toxic
anti-HIV
therapeutics.
Imidazole,
oxazole
thiazole
two
heteroatoms
at
meta-position
five-membered
rings
are
fascinating
structures
constitute
important
class
heterocycles
in
discovery.
Their
derivatives
could
exert
activity
through
diverse
mechanisms
possess
promising
antiviral
against
both
drug-sensitive
drug-resistant
strains.
This
review
summarizes
research
progress
made
regarding
potential
imidazole,
hybrids,
structure–activity
relationships
(SARs)
also
discussed
facilitate
further
rational
design
candidates,
covering
articles
published
from
2012
2022.
Asian Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: Nov. 26, 2022
Abstract
In
multicomponent
reactions,
three
or
more
reactants
combine
in
one
pot
to
form
a
product
without
the
isolation
of
intermediate
and
most
contribute
newly
formed
reducing
number
steps
involved
waste
generated.
Molecular
iodine
is
mild,
efficient,
relatively
nontoxic,
inexpensive,
commercially
available,
catalyzes
various
organic
reactions
due
its
Lewis
acidic
behaviour.
The
development
catalyzed
by
molecular
indeed
good
green
alternative
for
synthetic
chemistry.
aim
this
article
review
all
important
reported
since
2013
order
envisage
some
new
efficient
protocols
synthesis
structurally
complex
molecules.
