Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Feb. 10, 2023
Abstract
Medicinal
plants
possess
range
of
phytochemicals
accountable
for
their
diverse
biological
activities.
Presently,
such
compounds
have
been
isolated
from
medicinal
plants,
characterized
and
evaluated
pharmacological
potential.
In
the
present
study,
efforts
made
to
isolate
compound(s)
Grewia
tiliaefolia
Vahl.,
plant
known
its
ameliorative
effect
on
brain
related
diseases
as
anxiety,
depression,
cognitive
disorders
Parkinson’s
disease.
Plant
extract
was
subjected
isolation
using
column
chromatography
compound
by
NMR
FTIR
LCMS.
The
novel
with
IUPAC
name
is
propyl
3-hydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylate,
designated
A-1
has
not
reported
before.
further
antioxidant
potential
in
vitro
assays
(2,2-diphenyl-1-picryl-hydrazyl-hydrate,
DPPH
assay
reducing
power
assay,
RPA).
Also,
Acetylcholinesterase
(AChE)
inhibitory
analysed.
Results
showed
that
exhibited
significantly
higher
activity
both
RPA
compared
extract.
case
AChE
again,
shown
silico
study
conducted
predict
action
proteins
playing
crucial
role
neurological
neurodegenerative
gamma
amino
butyric
acid
(GABA)
receptor
glutamate
α
amino-3-hydroxyl-5-methyl-4-isoxazolepropionic
(Glu
AMPA)
epilepsy
enzyme
Alzheimer’s
diseases.
interaction
following
order:
>
GABA
Glu
AMPA
receptor.
Further,
molecular
dynamic
simulations
ADME
studies
revealed
yielded
good
results
all
parameters
hence
can
relieve
like
symptoms.
Archiv der Pharmazie,
Journal Year:
2024,
Volume and Issue:
357(8)
Published: May 21, 2024
Abstract
Novel
synthesized
pyrimidine
derivatives
were
investigated
against
carbonic
anhydrase
isoenzymes
I
and
II
(hCA
II),
acetylcholinesterase
(AChE),
butyrylcholinesterase
(BChE),
α‐glycosidase,
aldose
reductase
(AR)
enzymes
associated
with
some
common
diseases
such
as
epilepsy,
glaucoma,
Alzheimer's
disease,
diabetes,
neuropathy.
When
the
results
examined,
novel
found
to
have
effective
inhibition
abilities
toward
metabolic
enzymes.
IC
50
values
K
i
calculated
for
each
derivative
compared
positive
controls.
The
exhibited
in
range
of
39.16
±
7.70–144.62
26.98
nM
hCA
I,
18.21
3.66–136.35
21.48
II,
which
is
different
pathological
physiological
processes,
33.15
4.85–52.98
19.86
on
AChE,
31.96
8.24–69.57
21.27
BChE.
Also,
determined
17.37
1.11–253.88
39.91
α‐glycosidase
648.82
53.74–1902.58
98.90
AR
Within
scope
study,
types
evaluated.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Jan. 2, 2024
Abstract
Xanthine
oxidase
(XO)
is
a
crucial
enzyme
in
the
development
of
hyperuricemia
and
gout.
This
study
focuses
on
LWM
ALPM,
two
food-derived
inhibitors
XO.
We
used
molecular
docking
to
obtain
three
systems
then
conducted
200
ns
dynamics
simulations
for
Apo,
LWM,
ALPM
systems.
The
results
reveal
stronger
binding
affinity
peptide
XO,
potentially
due
increased
hydrogen
bond
formation.
Notable
changes
were
observed
XO
tunnel
upon
inhibitor
binding,
particularly
with
which
showed
thinner,
longer,
more
twisted
configuration
compared
ALPM.
highlights
importance
residue
F914
allosteric
pathway.
Methodologically,
we
utilized
perturbed
response
scan
(PRS)
based
Python,
enhancing
tools
MD
analysis.
These
findings
deepen
our
understanding
anti-XO
could
inform
food-based
therapeutics
reducing
uric
acid
levels
minimal
side
effects.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(24), P. 15893 - 15893
Published: Dec. 14, 2022
Redox
equilibria
and
the
modulation
of
redox
signalling
play
crucial
roles
in
physiological
processes.
Overproduction
reactive
oxygen
species
(ROS)
disrupts
body's
antioxidant
defence,
compromising
homeostasis
increasing
oxidative
stress,
leading
to
development
several
diseases.
Manganese
superoxide
dismutase
(MnSOD)
is
a
principal
enzyme
that
protects
cells
from
damage
by
converting
anion
radicals
hydrogen
peroxide
mitochondria.
Systematic
studies
have
demonstrated
MnSOD
plays
an
indispensable
role
multiple
This
review
focuses
on
preclinical
evidence
describes
mechanisms
diseases
accompanied
with
imbalanced
status,
including
fibrotic
diseases,
inflammation,
diabetes,
vascular
neurodegenerative
cancer.
The
potential
therapeutic
effects
activators
mimetics
are
also
discussed.
Targeting
this
specific
radical
scavenger
may
be
clinically
beneficial
strategy,
understanding
provide
positive
insight
into
preventing
treating
related
Chemistry & Biodiversity,
Journal Year:
2022,
Volume and Issue:
19(8)
Published: July 7, 2022
Abstract
In
the
current
study,
some
phenolic
compounds,
including
acteoside,
isoacteoside,
echinacoside,
and
arenarioside
purified
characterized
from
Plantago
subulata
.
These
compounds
were
tested
for
its
antioxidant
potential,
Fe
3+
Cu
2+
reductive
ability
chelating
effects.
The
inhibitory
effects
of
isolated
towards
human
carbonic
anhydrase
I
II
isoenzymes
(hCA
hCA
II),
butyrylcholinesterase
(BChE)
acetylcholinesterase
(AChE),
aldose
reductase
(AR)
α‐glycosidase
(α‐gly).
K
i
values
found
these
in
range
0.24±0.05–1.38±0.34
μM
against
I,
0.194±0.018–1.03±0.06
II,
0.043±0.01–0.154±0.02
AChE,
3.92±1.08–11.93±4.45
BChE,
0.082±0.0008–1.68±0.42
AR,
6.93±2.74–17.17±6.70
α‐glycosidase.
As
a
result,
displayed
inhibition
studied
all
metabolic
enzymes.
They
are
promising
candidates
treating
disorders
like
Alzheimer's
disease,
diabetes
mellitus,
glaucoma,
leukemia,
epilepsy.
