Complex gene-dependent and-independent mechanisms control daily rhythms of hematopoietic cells

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117803 - 117803

Published: Jan. 2, 2025

Language: Английский

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Role of Melatonin in Viral, Bacterial and Parasitic Infections

Biomolecules, Journal Year: 2024, Volume and Issue: 14(3), P. 356 - 356

Published: March 16, 2024

In all mammals, the circulating pool of MLTs is synthesized in pineal gland during night’s darkness hours. Its main function synchronizing organism photoperiod. contrast, extra-pineal MLT peripheral organs, does not follow any circadian rhythm or circulate, and plays a detoxifying cytoprotective role. Circulating may stimulate both innate acquired immune responses through its action by activating high-affinity receptors on immunocompetent cells. Extra-pineal have antioxidant anti-inflammatory effects that dampen response. These two seemingly divergent roles be considered to sides same coin. fact, integration functions might generate balanced effective response against microbial pathogens. The studies described this review investigated exogenous various models infectious diseases using extremely different doses treatment schedules. None them evaluated possibility integrating non-circadian effect with immunoenhancing MLT. As consequence, spite fact most agree has beneficial infections, it seems difficult draw definite conclusion about possible therapeutic use.

Language: Английский

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Modulations of circadian blood pressure rhythm in the COVID-19 risk model in individuals with arterial hypertension under Arctic watch conditions

Arterial’naya Gipertenziya (Arterial Hypertension), Journal Year: 2025, Volume and Issue: 30(5), P. 487 - 496

Published: Jan. 21, 2025

Objective. To study the characteristics of daily rhythm and chronostructure blood pressure (BP) in relation to viral infection determine factors influencing risk COVID-19 men (M) with arterial hypertension (HTN) during rotational shift work Arctic. Design methods. In Yamburg settlement, 166 M HTN were randomly selected from database physical examinations medical unit gazprom dobycha LLC. They underwent 24-hour ambulatory BP monitoring (ABPM) echocardiography “pre-C OVID” period (2019 — March 2020), after which divided into groups (n = 94) those without 72), comparable age northern experience. The diagnosis was based on detection SARS-CoV-2 RNA by polymerase chain reaction method. ABPM performed using a standard method determination chronotypes according classification Cugini P. Results. According data period, who subsequently recovered had higher average diastolic BP, night heart rate readings, systolic time index; chronotype characterized lower frequency rhythms aperiodic high-frequency spectrum significantly more frequent; significant increase left ventricular myocardial mass index found. logistic regression data, presence an increased 3 times (95 % confidence interval (CI): 1,410– 6,035, p 0,004); 1 g/m 2 1,02 CI: 1,001–1,033, 0,039). specificity model 81 %, sensitivity 77,2 %. area under curve 0,888 (0,837–0,939, < 0,0001). Conclusions. conditions desynchronizing Arctic watch HTN, replacement predominant periods is associated infection.

Language: Английский

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Investigating the circadian rhythm signaling pathway in HTLV-1 pathogenesis using Boolean analysis

Virus Research, Journal Year: 2025, Volume and Issue: 353, P. 199539 - 199539

Published: Feb. 12, 2025

The Human T-cell lymphotropic virus type 1 (HTLV-1), an oncogenic belonging to the Deltaretrovirus genus, expresses various proteins, including Tax and HBZ, which can affect many cellular pathways. In this study, we have investigated role of circadian rhythm signaling pathway, a key regulator human health, in pathogenesis HTLV-1 using Boolean Network analysis laboratory methods. After extensive search analyzed relationships between genes pathway R programming language BoolNet package. Subsequently, examined impact viral proteins on clock genes. Finally, identified three genes, PER2, CRY1, DEC1, as main checkpoints from attractors obtained. These two were quantitatively assessed groups individuals, ten asymptomatic carriers infected with healthy individuals qRT-PCR method. Our results showed that expression level PER2 DEC1 was significantly higher compared control group. Also, recorded positive correlations CRY1 negative HBZ DEC1. suggested carriers, might try induce chronic infection by escaping immune system due alteration We also detected promising could therapeutic or diagnostic value these individuals. However, possibility requires further research different periods, (e.g., ATLL HAM/TSP), examining more significant number

Language: Английский

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Circadian syndrome and mortality risk in adults aged ≥ 40 years: a prospective cohort analysis of CHARLS and NHANES

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 28, 2025

Circadian rhythm disruption is increasingly prevalent and associated with higher morbidity mortality. This study investigates the relationship between Rhythm Syndrome (CircS) mortality in middle-aged older adults. prospective cohort utilized follow-up data from China Health Retirement Longitudinal Study (CHARLS) National Nutrition Examination Survey (NHANES). Cox proportional hazards models examined association CircS all-cause mortality, while restricted cubic spline analysis explored non-linear relationships. Subgroup analyses investigated potential modifying factors. Bayesian generalized linear were used to explore relationships specific causes of death. The included 7,637 participants CHARLS (2011-2020) 9,320 NHANES (2005-2018), 142 1,321 deaths. periods 9.17 years for 15 NHANES. was significantly increased risk (CHARLS: HR 1.79, 95% CI: 1.23-2.62; NHANES: 1.21, 1.03-1.42). A dose-response observed number components risk. positively diabetes, cardiovascular, cerebrovascular, kidney-related diseases. strongly These findings underscore importance addressing circadian disruptions public health strategies.

Language: Английский

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Role of Melatonin in Viral, Bacterial and Parasitic Infections

Published: March 26, 2024

In all mammals, the circulating pool of MLT is synthesized in pineal gland, during night darkness hours. Its main function that synchronizing organism photoperiod. contrast, extra-pineal peripheral organs, does not follow any circadian rhythm nor circulates and plays a detoxifying cytoprotective action. Circulating may stimulate both innate acquired immune responses by its action activating high affinity receptors on immunocompetent cells. Extra-pineal have anti-oxidant anti-inflammatory effects dampening response. These two seemingly divergent roles be considered as faces same coin. fact, integration functions might generate balanced effective response against microbial pathogens. The studies described this review investigated effect exogenous various models infectious diseases using extremely different doses treatment schedules. None them evaluated possibility to integrate non-circadian with immunoenhancing MLT. As consequence, spite most agree has beneficial infections, it seems difficult draw definite conclusion about possible therapeutic use.

Language: Английский

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The Complex Relationship Between Chronic Obstructive Pulmonary Disease With Cardiovascular Disease and Their Interactions With COVID‐19 Vaccination: A Retrospective Study

Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(11)

Published: Nov. 1, 2024

Previously, most researchers explored the association between chronic obstructive pulmonary disease (COPD) and cardiovascular (CVD). This study investigates distinct influence of COVID-19 vaccination status on patients with both conditions.

Language: Английский

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Circadian regulation of the immune-hematopoietic system

Exploration of neuroscience, Journal Year: 2023, Volume and Issue: unknown, P. 123 - 139

Published: June 30, 2023

Earth’s rotation generates the basic circadian rhythm of day and night to which all living organisms must adapt survive. In mammals, this happens thanks a central clock located in suprachiasmatic nucleus (SCN) hypothalamus peripheral genes at cellular level. The main environmental cue capable synchronizing such clocks is light sensed by retinal ganglion cells signaling through complex nervous pathway pineal gland ultimately regulates melatonin synthesis that occurs during night, darkness hours mammals. synchronized drives oscillation sympathetic system (SNS) adrenergic activity turn controls glucocorticoid production adrenal glands. These oscillations are integrated with still not completely understood mechanisms drive homeostatic control activity-rest (sleep) cycles, cardiovascular activity, body temperature, immune-hematopoietic functions. neuronal hormonal governing hematopoiesis immunity will be addressed review focusing on those offering therapeutic perspectives.

Language: Английский

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Streptococcus pneumoniaeaugments circadian clock gene expression in zebrafish cells

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 22, 2024

Abstract The circadian clock is a highly coordinated, cell-autonomous process that regulates the daily internal rhythms of biological organisms. Circadian clocks have been identified in various organisms, including mammals, invertebrates, cyanobacteria, and plants. zebrafish ( Danio rerio ) practical model for studying vertebrate due to its small size, ease manipulation, gene tractability, direct light responsiveness. Several studies revealed bacterial, viral, parasitic infections can impact expression genes mammals. While some evidence suggests this may also be case zebrafish, no investigated effects bacterial exposure on clock. Here, using Z3 cells, we show heat-killed Streptococcus pneumoniae (HK-Spn) augment core repressive factors, per1b, per2, per3, cry1a . Further investigation demonstrated HK-Spn induces production reactive oxygen species (ROS) cells addition NAC, ROS antioxidant, blocks Spn-mediated induction per2 , per3 Additionally, augmented tefa tefb, an effect NAC suppressed. These results suggest involvement ROS-dependent pathway augmentation cry1a, by HK-Spn. Moreover, activation tefb represents promising new targets further regulation these genes.

Language: Английский

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Role of Melatonin in Viral, Bacterial and Parasitic Infections

Published: Feb. 26, 2024

In all mammals, the circulating pool of MLT is synthesized in pineal gland, during night darkness hours. Its main function that synchronizing organism photoperiod. contrast, extra-pineal peripheral organs, does not follow any circadian rhythm nor circulates and plays a detoxifying cytoprotective action. Circulating may stimulate both innate acquired immune responses by its action activating high affinity receptors on immunocompetent cells. Extra-pineal have anti-oxidant anti-inflammatory effects dampening response. These two seemingly divergent roles be considered as faces same coin. fact, integration functions might generate balanced effective response against microbial pathogens. The studies described this review investigated effect exogenous various models infectious diseases using extremely different doses treatment schedules. None them evaluated possibility to integrate non-circadian with immunoenhancing MLT. As consequence, spite most agree has beneficial infections, it seems difficult draw definite conclusion about possible therapeutic use.

Language: Английский

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