MedComm – Oncology,
Journal Year:
2024,
Volume and Issue:
3(4)
Published: Dec. 1, 2024
Abstract
Cancer
stem
cells
(CSCs)
are
a
small
group
of
tumor
with
the
capacity
to
undergo
self‐renewal
and
differentiation.
These
not
only
initiate
maintain
growth,
but
also
confer
resistance
current
cancer
therapies.
CSCs
display
high
degree
plasticity
can
be
generated
under
therapeutic
stress
via
dedifferentiation
from
non‐stem‐like
cells,
suggesting
necessity
simultaneously
targeting
bulk
achieve
best
effect.
Despite
findings
that
induces
CSC
plasticity,
mechanisms
underpinning
formation
fully
defined.
Tumor
elevated
levels
reactive
oxygen
species
(ROS),
contributed
by
rapid
proliferation,
enhanced
metabolic
demands
oncogenic
signaling.
redox
homeostasis
partly
regulating
redox‐sensitive
transcription
factors
(TFs),
including
NRF2,
HIF‐1α,
BACH1,
NF‐kB,
FOXOs,
AP‐1,
others.
This
review
aims
summarize
roles
underlying
these
TFs
in
regulation
progression
perspectives
cell
maintenance,
reprogramming,
epithelial–mesenchymal
transition
(EMT)
angiogenesis.
We
discuss
potentials
utilizing
specific
inhibitors
for
suppressing
drug
metastasis
repressing
activity,
an
approach
may
provide
new
targeted
therapies
advanced
improve
patient
outcome.
Cancer Cell International,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Feb. 28, 2024
Cancer
chemoresistance
is
a
problematic
dilemma
that
significantly
restrains
numerous
cancer
management
protocols.
It
can
promote
recurrence,
spreading
of
cancer,
and
finally,
mortality.
Accordingly,
enhancing
the
responsiveness
cells
towards
chemotherapies
could
be
vital
approach
to
overcoming
chemoresistance.
Tumour
express
high
level
sphingosine
kinase-1
(SphK1),
which
acts
as
protooncogenic
factor
responsible
for
synthesis
sphingosine-1
phosphate
(S1P).
S1P
released
through
Human
ATP-binding
cassette
(ABC)
transporter
interact
with
other
phosphosphingolipids
components
in
interstitial
fluid
tumor
microenvironment
(TME),
provoking
communication,
progression,
invasion,
metastasis.
Also,
associated
several
impacts,
including
anti-apoptotic
behavior,
metastasis,
mesenchymal
transition
(EMT),
angiogenesis,
chemotherapy
resistance.
Recent
reports
addressed
levels
carcinomas,
ovarian,
prostate,
colorectal,
breast,
HCC.
Therefore,
targeting
S1P/SphK
signaling
pathway
an
emerging
therapeutic
efficiently
attenuate
In
this
review,
we
comprehensively
discussed
functions,
metabolism,
transport,
signaling.
bioinformatic
framework,
pointed
out
alterations
SphK1
gene
expression
within
different
cancers
their
impact
on
patient
survival,
demonstrated
protein-protein
network
SphK1,
elaborating
its
sparse
roles.
Furthermore,
made
emphasis
machineries
resistance
tight
link
S1P.
We
evaluated
all
publicly
available
inhibitors
inhibition
activity
using
molecular
docking
how
reduce
production
might
chemoresistance,
course
treatment
prognosis.
Biochemia Medica,
Journal Year:
2023,
Volume and Issue:
33(3), P. 266 - 278
Published: Oct. 11, 2023
One
of
the
most
important
factors
involved
in
response
to
oxidative
stress
(OS)
is
nuclear
factor
erythroid
2-related
2
(Nrf2),
which
regulates
expression
components
such
as
antioxidative
proteins
and
enzymes.
Under
normal
conditions,
Kelch-like
ECH-associated
protein
1
(Keap1)
keeps
Nrf2
cytoplasm,
thus
preventing
its
translocation
nucleus
inhibiting
role.
It
has
been
established
that
a
dual
function;
on
one
hand,
it
promotes
angiogenesis
cancer
cell
metastasis
while
causing
resistance
drugs
chemotherapy.
On
other
increases
proliferation
glutathione
protect
cells
against
OS.
p53
tumour
suppressor
activates
apoptosis
pathway
aging
addition
stimulating
glutaminolysis
antioxidant
pathways.
Cancer
use
ability
Therefore,
present
study,
we
discussed
function
breast
(BC)
elucidate
their
role
protection
or
destruction
well
drug
properties.
Cell Communication and Signaling,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Nov. 9, 2023
Abstract
According
to
a
paper
released
and
submitted
WHO
by
IARC
scientists,
there
would
be
905,700
new
cases
of
liver
cancer
diagnosed
globally
in
2020,
with
830,200
deaths
expected
as
direct
result.
Hepatitis
B
virus
(HBV)
hepatitis
C
(HCV),
D
(HDV)
all
play
critical
roles
the
pathogenesis
hepatocellular
carcinoma
(HCC),
despite
rising
prevalence
HCC
due
non-infectious
causes.
Liver
cirrhosis
are
devastating
consequences
HBV
HCV
infections,
which
widespread
worldwide.
Associated
high
mortality
rate,
these
infections
cause
about
1.3
million
annually
primary
globally.
In
addition
causing
insertional
mutations
viral
gene
integration,
epigenetic
alterations
inducing
chronic
immunological
dysfunction
methods
viruses
turn
hepatocytes
into
cancerous
ones.
While
expanding
our
knowledge
illness,
identifying
pathways
also
give
possibilities
for
novel
diagnostic
treatment
methods.
Nuclear
factor
erythroid
2-related
2
(NRF2)
activation
is
gaining
popularity
option
oxidative
stress
(OS),
inflammation,
metabolic
abnormalities.
Numerous
studies
have
shown
that
elevated
Nrf2
expression
linked
HCC,
providing
more
evidence
HCC.
This
aberrant
signaling
drives
cell
proliferation,
initiates
angiogenesis
invasion,
imparts
drug
resistance.
As
result,
this
master
regulator
may
promising
target
addition,
common
effect
contributes
pathogenesis,
development,
chronicity
infection.
However,
certain
suppress
activity,
helpful
maintaining
cellular
homeostasis.
paper,
we
discussed
influence
deregulation
on
life
cycle
associated
HCV.
We
summed
up
mechanisms
modulation
deregulated
viruses.
Moreover,
describe
molecular
mechanism
modulated
cancer,
stem
cells
(LCSCs),
caused
Hormone Molecular Biology and Clinical Investigation,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 12, 2024
Abstract
One
of
the
biggest
challenges
today’s
society
is
cancer,
which
imposes
a
significant
financial,
emotional
and
spiritual
burden
on
human
life.
Breast
cancer
(BC)
one
most
common
cancers
that
affects
people
in
society,
especially
women,
due
to
advanced
treatment
strategies
primary
prevention,
it
still
second
cause
cancer-related
deaths
society.
Various
genetic
environmental
factors
are
involved
development
BC.
MicroRNAs
(miRNA)s
non-coding
RNAs,
degradation
or
inhibition
them
plays
an
important
role
prevention
by
modulating
many
cellular
pathways
including
apoptosis,
drug
resistance,
tumorigenesis.
Drug
resistance
defense
mechanisms
cells
against
anticancer
drugs
considered
main
causes
failure.
Different
miRNAs,
mir-7,
mir-21,
mir-31,
mir-124
control
different
cell
activities,
through
pathways,
PI3K/AKT/mTOR,
TGF-β,
STAT3,
NF-kB.
Therefore,
signaling
miRNAs
activities.
Hence,
this
study,
we
decided
highlight
overview
relationship
between
Pharmacology Research & Perspectives,
Journal Year:
2025,
Volume and Issue:
13(1)
Published: Jan. 25, 2025
ABSTRACT
Doxorubicin
(DOXO)
has
long
been
used
clinically
and
remains
a
key
drug
in
cancer
therapy.
DOXO‐induced
cardiomyopathy
(DICM)
is
chronic
fatal
complication
that
severely
limits
the
use
of
DOXO.
However,
there
are
very
few
therapeutic
agents
for
DICM,
an
urgent
need
to
identify
those
can
be
larger
number
patients.
The
most
likely
pathogenic
mechanism
DICM
involvement
reactive
oxygen
species
(ROS)
promotion
cell
death.
In
this
study,
we
investigated
efficacy
action
edaravone
(EDA),
known
radical
scavenger
DICM.
Two
methods
EDA
administration
were
employed:
daily
weekly.
Our
results
showed
group
had
prolonged
survival
periods
preserved
left
ventricular
ejection
fraction
mice.
contrast,
weekly
treatment
group,
slight
improvements
observed
these
indicators
compared
with
mice;
however,
none
them
statistically
significant.
These
show
higher
than
group.
Gene‐expression
Nrf2
its
related
genes
upregulated
but
not
Based
on
results,
hypothesized
Sirt1/Nrf2/HO‐1
ABCB4
pathways
involved
EDA.
limited
evidence
effective
against
findings
obtained
herein
bolster
by
demonstrating
continued
preservation
cardiac
function
proposing
possible
mechanism.
