International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
26(1), P. 127 - 127
Published: Dec. 26, 2024
Breast
cancer
(BC)
is
one
of
the
most
prevalent
forms
globally,
and
has
recently
become
leading
cause
cancer-related
mortality
in
women.
BC
a
heterogeneous
disease
comprising
various
histopathological
molecular
subtypes
with
differing
levels
malignancy,
each
patient
an
individual
prognosis.
Etiology
pathogenesis
are
complex
involve
considerable
number
genetic
alterations
dozens
non-coding
RNA
expression.
Non-coding
RNAs
part
abundant
family
single-stranded
molecules
acting
as
key
regulators
DNA
replication,
mRNA
processing
translation,
cell
differentiation,
growth,
overall
genomic
stability.
In
context
breast
cancer,
involved
cycle
control
tumor
migration
invasion,
well
treatment
resistance.
Alterations
expression
may
contribute
to
development
progression
making
them
promising
biomarkers
targets
for
novel
therapeutic
approaches.
Currently,
use
not
yet
been
applied
routine
practice;
however,
their
potential
very
studied.
The
present
review
literature
overview
current
knowledge
its
objective
delineate
function
diverse
classes
particular
emphasis
on
utility
diagnostic
prognostic
markers
or
tools.
Biology of the Cell,
Journal Year:
2025,
Volume and Issue:
117(1)
Published: Jan. 1, 2025
Ferroptosis
is
a
type
of
cell
death
that
multiple
mechanisms
and
pathways
contribute
to
the
positive
negative
regulation
it.
For
example,
increased
levels
reactive
oxygen
species
(ROS)
induce
ferroptosis.
ferroptosis
unlike
apoptosis,
it
not
dependent
on
caspases,
but
iron.
Exosomes
are
membrane-bound
vesicles
with
size
about
30
150
nm,
contain
various
cellular
components,
including
DNA,
RNA,
microRNAs
(miRNAs),
lipids,
proteins,
which
genetically
similar
their
cells
origin.
found
in
all
bodily
fluids,
blood,
saliva,
urine.
Cells
often
release
exosomes
after
fusion
membrane.
They
play
an
important
role
immune
cell-cell
communication.
miRNAs,
noncoding
RNAs
length
18
24
nucleotides,
involved
regulating
gene
expression
transcription.
Emerging
data
suggests
exosomal
miRNAs
implicated
pathophysiological
cells,
metastasis,
drug
resistance,
death.
In
addition,
functional
studies
have
indicated
can
key
modulation
by
Therefore,
this
review,
given
importance
ferroptosis,
we
decided
elucidate
relationship
between
diseases.
Hormone Molecular Biology and Clinical Investigation,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 12, 2024
Abstract
One
of
the
biggest
challenges
today’s
society
is
cancer,
which
imposes
a
significant
financial,
emotional
and
spiritual
burden
on
human
life.
Breast
cancer
(BC)
one
most
common
cancers
that
affects
people
in
society,
especially
women,
due
to
advanced
treatment
strategies
primary
prevention,
it
still
second
cause
cancer-related
deaths
society.
Various
genetic
environmental
factors
are
involved
development
BC.
MicroRNAs
(miRNA)s
non-coding
RNAs,
degradation
or
inhibition
them
plays
an
important
role
prevention
by
modulating
many
cellular
pathways
including
apoptosis,
drug
resistance,
tumorigenesis.
Drug
resistance
defense
mechanisms
cells
against
anticancer
drugs
considered
main
causes
failure.
Different
miRNAs,
mir-7,
mir-21,
mir-31,
mir-124
control
different
cell
activities,
through
pathways,
PI3K/AKT/mTOR,
TGF-β,
STAT3,
NF-kB.
Therefore,
signaling
miRNAs
activities.
Hence,
this
study,
we
decided
highlight
overview
relationship
between
Genes,
Journal Year:
2025,
Volume and Issue:
16(3), P. 295 - 295
Published: Feb. 28, 2025
Background/Objectives:
MicroRNAs
(miRNAs)
play
a
crucial
role
in
regulating
immune
responses
and
have
been
implicated
the
pathogenesis
of
various
nasal
diseases,
including
chronic
rhinosinusitis
(CRS),
allergic
rhinitis
(AR),
sinonasal
tumors.
This
review
comprehensively
explores
emerging
miRNAs
inflammatory
oncological
highlighting
their
diagnostic,
prognostic,
therapeutic
potential.
Methods:
A
comprehensive
literature
was
conducted
to
summarize
current
findings
on
miRNA
expression
conditions
Key
studies
evaluating
miRNA-mediated
regulatory
mechanisms,
potential
biomarker
applications,
approaches
were
analyzed.
Results:
Altered
profiles
contribute
CRS,
AR,
Specific
miRNAs,
such
as
miR-125b
miR-155
are
upregulated
CRS
promoting
inflammation
tissue
remodeling.
In
tumors,
dysregulated
miR-126
miR-34/miR-449
clusters,
influence
tumor
progression
response.
Exosome-mediated
delivery
emerges
promising
avenue
for
precision
medicine,
offering
novel
strategies
miRNA-based
diagnostics
therapies.
Conclusions:
key
regulators
with
applications
non-invasive
targeted
Further
research
into
interventions
may
improve
treatment
outcomes
development
personalized
medicine
disorders
malignancies.
