The 2021 World Health Organization Central Nervous System Tumor Classification: The Spectrum of Diffuse Gliomas DOI Creative Commons
Racine Gue, Dhairya A. Lakhani

Biomedicines, Journal Year: 2024, Volume and Issue: 12(6), P. 1349 - 1349

Published: June 18, 2024

The 2021 edition of the World Health Organization (WHO) classification central nervous system tumors introduces significant revisions across various tumor types. These updates, encompassing changes in diagnostic techniques, genomic integration, terminology, and grading, are crucial for radiologists, who play a critical role interpreting brain imaging. Such impact diagnosis management nearly all categories, including reclassification, addition, removal specific entities. Given their pivotal patient care, radiologists must remain conversant with these to effectively contribute multidisciplinary boards collaborate peers neuro-oncology, neurosurgery, radiation oncology, neuropathology. This knowledge is essential not only accurate staging, but also understanding molecular genetic underpinnings tumors, which can influence treatment decisions prognostication. review, therefore, focuses on most pertinent updates concerning adult diffuse gliomas, highlighting aspects relevant radiological practice. Emphasis placed implications new information behavior imaging findings, providing necessary tools stay abreast advancements field. comprehensive overview aims enhance radiologist’s ability integrate WHO criteria into everyday practice, ultimately improving outcomes through informed precise assessments.

Language: Английский

Comparative Clinical-Imaging and Histogenetic Analysis Between Astrocytoma IDH-Mutant Grade 4 and Glioblastoma IDH-Wildtype—Is There Really a Worse One? DOI Creative Commons
Cristian Ionuț Orășanu, Mariana Aşchie, Mariana Deacu

et al.

Diagnostics, Journal Year: 2025, Volume and Issue: 15(4), P. 438 - 438

Published: Feb. 11, 2025

Background: Brain tumors pose a significant health threat, leading to high morbidity and mortality rates. Astrocytoma IDH-mutant grade 4 (A4IDHmt) glioblastoma IDH-wildtype (G4IDHwt) exhibit similar clinical imaging characteristics. This study aims highlight the differences in their evolution histogenetic aspects with possible therapeutic impact, as well adverse prognostic factors patient survival. Methods: We performed 10-year retrospective of gliomas, evaluating immunomarkers FISH tests. also quantified tumor necrosis microvascular density. Results: A total 81 cases were identified; 54.32% A4IDHmt. observed that A4IDHmt patients younger (34.10% under 50) had higher survival rate (4.55%). group exhibited more pronounced density (p = 0.010) proliferative index 0.026). G4IDHwt was associated larger volumes (94.84 cm3 vs. 86.14 cm3), lower resectability rates (82.88% 87.67%), immature cell population (83.78% 68.18%). In case both, negative risk on univariate analysis is given by advanced age (A4IDHmt: HR 1.035, G4IDHwt: 1.045) p53 immunopositivity 6.962, 4.680). Conclusions: The for include rapid onset symptoms (HR 2.038), diabetes mellitus 2.311), arterial hypertension 2.325), residual 2.662), increased volume 1.060), 1.096), 1.097). For G4IDHwt, consist 1.023), lost PTEN immunoreaction 33.133), unmethylated DNA status 6.765, respectively 20.573). Even if it has factors, lesser evil.

Language: Английский

Citations

0
CRISPR/Cas-mediated macromolecular DNA methylation editing: Precision targeting of DNA methyltransferases in cancer therapy DOI

Feng Chena,

Lu Chenb

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142401 - 142401

Published: March 1, 2025

Language: Английский

Citations

0
The 2021 World Health Organization Central Nervous System Tumor Classification: The Spectrum of Diffuse Gliomas DOI Creative Commons
Racine Gue, Dhairya A. Lakhani

Biomedicines, Journal Year: 2024, Volume and Issue: 12(6), P. 1349 - 1349

Published: June 18, 2024

The 2021 edition of the World Health Organization (WHO) classification central nervous system tumors introduces significant revisions across various tumor types. These updates, encompassing changes in diagnostic techniques, genomic integration, terminology, and grading, are crucial for radiologists, who play a critical role interpreting brain imaging. Such impact diagnosis management nearly all categories, including reclassification, addition, removal specific entities. Given their pivotal patient care, radiologists must remain conversant with these to effectively contribute multidisciplinary boards collaborate peers neuro-oncology, neurosurgery, radiation oncology, neuropathology. This knowledge is essential not only accurate staging, but also understanding molecular genetic underpinnings tumors, which can influence treatment decisions prognostication. review, therefore, focuses on most pertinent updates concerning adult diffuse gliomas, highlighting aspects relevant radiological practice. Emphasis placed implications new information behavior imaging findings, providing necessary tools stay abreast advancements field. comprehensive overview aims enhance radiologist’s ability integrate WHO criteria into everyday practice, ultimately improving outcomes through informed precise assessments.

Language: Английский

Citations

2