Clinical Microbiology and Infection, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Clinical Microbiology Reviews, Journal Year: 2024, Volume and Issue: 37(2)
Published: April 11, 2024
SUMMARYFungal infections are on the rise, driven by a growing population at risk and climate change. Currently available antifungals include only five classes, their utility efficacy in antifungal treatment limited one or more of innate acquired resistance some fungi, poor penetration into "sequestered" sites, agent-specific side effect which require frequent patient reassessment monitoring. Agents with novel mechanisms, favorable pharmacokinetic (PK) profiles including good oral bioavailability, fungicidal mechanism(s) urgently needed. Here, we provide comprehensive review agents, both improved known mechanisms actions new currently clinical development for treating invasive yeast, mold (filamentous fungi),
Language: Английский
Citations
34
Journal of Infection, Journal Year: 2024, Volume and Issue: 89(3), P. 106229 - 106229
Published: July 16, 2024
Language: Английский
Citations
16
Mycopathologia, Journal Year: 2024, Volume and Issue: 189(3)
Published: May 5, 2024
Abstract Background The global prevalence of invasive fungal infections (IFI) is increasing, particularly within Intensive Care Units (ICU), where Candida spp. and Aspergillus represent the most important pathogens. Diagnosis management IFIs becomes progressively challenging, with increasing antifungal resistance emergence rare species. Through a consensus survey focused on assessing current views how IFI should be managed, aim this project was to identify challenges around diagnosing managing in ICU. status different countries perceived date amongst multidisciplinary cohort healthcare professionals involved care ICU assessed. Methods Using modified Delphi approach, an expert panel developed 44 Likert-scale statements across 6 key domains concerning patient screening minimal standards for diagnosis ICU; initiation termination treatments minimise their side effects insights future research topic. These were used develop online which distributed convenience sampling basis utilising subscriber list held by independent provider (M3 Global). This intensivists, infectious disease specialists, microbiologists antimicrobial/ICU pharmacists UK, Germany, Spain, France Italy. threshold set at 75%. Results A total 335 responses received during five-month collection period. From these, 29/44 (66%) attained very high agreement (90%), 11/44 (25%) (< 90% ≥ 75%), 4/44 (9%) did not meet 75%). Conclusion results outline need physicians aware local incidence associated rate azole ICUs. Where clinical suspicion exists, treatment start immediately prior receiving from any diagnostic test. Beta-D-glucan testing available all centres, 48 h inform cessation empirical therapy. proposed measures may guide areas further optimise
Language: Английский
Citations
7
Journal of Infection, Journal Year: 2025, Volume and Issue: unknown, P. 106435 - 106435
Published: Feb. 1, 2025
Highlights•Pharmacokinetics/pharmacodynamics of antifungals can be impacted by various factors•Special populations with candidaemia/invasive candidiasis may need dose alterations•Such special include the elderly, obese or those organ dysfunction•Rezafungin appears suitable for many without modifications•Future research should aim to generate data on rezafungin in other populationsSummaryAchieving and maintaining therapeutic drug exposures challenging patient populations, such as dysfunction (liver kidney) obesity, elderly patients, due dose–exposure relationships potential drug–drug interactions. Dose adjustments needed these maintain efficacy and/or prevent toxicity. We reviewed specific dosing considerations candidaemia invasive candidiasis, focusing relating echinocandins (based prescribing information), then explored utility second-generation echinocandin treating currently available identified from a PubMed congress abstract search). Available showed that sometimes require modifications primarily decreases pharmacokinetic exposures. Rezafungin use variety based data, including patients critically ill patients. Further is where are not children, people living HIV, receiving ECMO underlying neurological conditions.
Language: Английский
Citations
0
Revista Iberoamericana de Micología, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0
Microorganisms, Journal Year: 2025, Volume and Issue: 13(5), P. 1085 - 1085
Published: May 7, 2025
Catheter-associated bloodstream infections (CABSIs) and catheter-related (CRBSIs) are significant causes of morbidity mortality worldwide. The current practice favors the removal vascular access devices (VADs); however, evidence on this topic remains inconclusive. This study evaluates clinical outcomes in terms in-hospital catheter retention vs. CABSI CRBSI cases. A retrospective, observational, single-center was conducted at Luigi Sacco Hospital, Milan, Italy (May 2021–December 2023), it analyzed non-ICU adult patients with VADs diagnosed CRBSIs or CABSIs. Clinical microbiological data were collected to assess based management. Among 1874 VADs, 147 included, 164 VAD infection events (92 CABSIs 72 CRBSIs). Overall, 35 (23.8%) died. Out those who retained 19 (35.8%) died, while among 16 (17%) died (p = 0.018). Candida spp. isolation found be significantly associated a higher likelihood 0.04). Our findings suggest that, cases, may improved when feasible.
Language: Английский
Citations
0
Mycoses, Journal Year: 2024, Volume and Issue: 67(7)
Published: June 27, 2024
Candidemia is a diverse condition and associated with broad spectrum of clinical presentation. As mortality high, timely diagnosis candidemia start correct therapeutic treatment are essential.
Language: Английский
Citations
3
Mycopathologia, Journal Year: 2024, Volume and Issue: 189(4)
Published: Aug. 1, 2024
Invasive candidiasis and candidemia remain a significant public health concern. The European Confederation of Medical Mycology (ECMM) conducted three pan-European multicentre studies from 1997 to 2022 investigate various aspects invasive Candida infections. These revealed shifting trends in species distribution, with an increase non-albicans as causative pathogens, increasing rates antifungal resistance, persistently high mortality rates. Despite advancements treatment, the rate drug well limited access low-income countries, underscore need for continued research development treatment This review aims summarize findings completed ECMM emphasize importance efforts. Additionally, it introduces upcoming IV study, which will focus on assessing caused by species, including auris, investigating resistance tolerance, evaluating novel modalities global scale.
Language: Английский
Citations
2
Diagnostics, Journal Year: 2024, Volume and Issue: 14(19), P. 2125 - 2125
Published: Sept. 25, 2024
Rapid molecular assays can be used to identify Candida pathogens directly from positive blood cultures (BCs) in a timely manner compared standard methods using subcultures. In this study, the eazyplex® ID assay, which is based on loop-mediated amplification (LAMP) and currently for research use only, was evaluated identification of most common fungal species. A total 190 BCs were analysed. Sensitivity specificity 93.88% 99.26% C. albicans, 89.13% 100% Nakaseomyces glabratus (N. glabratus), Pichia kudravzevii (P. kudriavzevii), tropicalis, 99.44% parapsilosis. Sample preparation took approximately 11 min results obtained between 8.5 19 min. The LAMP assay an easy-to-use diagnostic tool that optimise management patients with candidemia.
Language: Английский
Citations
1
Expert Review of Anti-infective Therapy, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 24, 2024
The rising prevalence of difficult-to-treat, deep-seated invasive fungal diseases (IFD) has led to high mortality. Currently available antifungal treatments, administered predominantly orally or intravenously, may not sufficiently penetrate certain body sites, and/or are associated with systemic toxicity. Little is known about how position alternative administration approaches such as inhalational and direct drug delivery routes.
Language: Английский
Citations
1