Cluster of clonal fluconazole-resistant Candida parapsilosis harbouring Y132F mutation in ERG11 gene in a neonatal ICU in the UK
Journal of Antimicrobial Chemotherapy,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 9, 2025
Language: Английский
Evaluation of Genotyping Methods for Tracking the Spread of Sporothrix During Epidemics and Outbreaks
Fungal Biology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 101566 - 101566
Published: March 1, 2025
Language: Английский
Genetic Epidemiology and Resistance Investigations of Clinical Yeasts in Alexandria, Egypt
Pathogens,
Journal Year:
2025,
Volume and Issue:
14(5), P. 486 - 486
Published: May 15, 2025
Yeast
bloodstream
infections
lead
to
high
mortality
and
morbidity
are
mostly
observed
in
immunocompromised
patients.
In
Africa,
only
a
few
studies
have
characterized
clinical
yeasts.
To
increase
insight
into
yeast
resistance
transmission
we
identified
various
yeasts
from
Alexandria,
Egypt
performed
antifungal
susceptibility
testing
(AFST)
genotyping.
A
total
of
1307
single
isolates
unique
patients,
recovered
different
anatomical
sites
including
the
bloodstream,
retrieved
reference
laboratory
were
studied.
All
with
MALDI-TOF
MS,
while
some
initially
Vitek
2
Compact
system.
Short
tandem
repeat
(STR)
genotyping
was
for
most
common
species,
AFST
microbroth
dilution.
Among
(n
=
71),
C.
albicans
etiological
agent,
followed
by
tropicalis
parapsilosis.
Comparison
identification
methods
demonstrated
that
22%
incorrectly
system
compared
MS.
Multiple
rare
showed
reduced
susceptibility.
STR
potential
events
nosocomial
N.
glabratus
Moreover,
an
azole-resistant
clade
earlier
Alexandria
still
present.
conclude,
Egypt,
overall
susceptible
species.
Language: Английский
Genotyping of Candida tropicalis isolates uncovers nosocomial transmission of two lineages in Italian tertiary-care hospital
Journal of Hospital Infection,
Journal Year:
2024,
Volume and Issue:
155, P. 115 - 122
Published: Oct. 18, 2024
Candida
tropicalis
is
a
medically
important
yeast
with
increasing
antifungal
resistance,
but
nosocomial
transmission
rarely
reported.
This
study
genotyped
C.
isolates
from
Italian
hospitals
to
uncover
potential
and
assess
resistance.
In
total,
197
161
patients
were
collected
five
centres
2013
2023.
Short
tandem
repeat
(STR)
genotyping
was
conducted
on
all
isolates,
selection
of
24
typed
whole-genome
sequencing
(WGS)
the
novel
Fourier-transform
infrared
(FTIR)
spectroscopy
method.
Antifungal
resistance
investigated
microbroth
dilution
WGS.
STR
revealed
seven
clusters
multiple
patients.
WGS
single
nucleotide
polymorphism
(SNP)
analysis
groups
related
genotypes
also
separated
these
into
groups,
which
two
contained
cluster
different
distinguished
by
≤59
SNPs.
comparison,
sequential
within
three
differentiated
≤141
The
clustered
based
FTIR
genotyping,
although
this
method
did
not
separate
groups.
None
resistant
common
antifungals.
SNP
indicated
lineages
same
hospital,
highlighting
need
for
enforced
infection
prevention
measures
routine
in
clinical
settings.
While
both
lineages,
required
determine
whether
transmitted
clonally.
Language: Английский
“CLADE-FINDER”: Candida auris Lineage Analysis Determination by Fourier Transform Infrared Spectroscopy and Artificial Neural Networks
Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(11), P. 2153 - 2153
Published: Oct. 26, 2024
In
2019,
Language: Английский
Follow the Path: Unveiling an Azole Resistant Candida parapsilosis Outbreak by FTIR Spectroscopy and STR Analysis
Journal of Fungi,
Journal Year:
2024,
Volume and Issue:
10(11), P. 753 - 753
Published: Oct. 30, 2024
Accurate
identification
and
rapid
genotyping
of
Language: Английский