Influence of long-term social isolation on the behavior and dopamine system of the brain in mice DOI
Д. В. Базовкина,

U. S. Ustinova,

S. N. Adonina

et al.

Российский физиологический журнал им  И  М  Сеченова, Journal Year: 2024, Volume and Issue: 110(2), P. 238 - 253

Published: Aug. 2, 2024

The dopamine brain system is involved in the regulation of various physiological processes and behavioral responses, including social behavior. It was shown rodents that prolonged isolation can lead to changes parameters neurochemical parameters, but these data remain unclear. In this work, we studied effects on behavior state male C57Bl/6 mice. Animals experimental group from age 40 - 42 days were kept individually separate cages for six weeks, while mice control in-group conditions. Isolation did not affect locomotor exploratory activity “open field” test compared content group. At same time, animals subjected demonstrated a longer duration contacts “resident-intruder” model weakening stereotypical “marbles burying” These accompanied by an increase mRNA levels genes encoding D1 D2 receptors striatum addition, level metabolite DOPAC decreased hypothalamus increased frontal cortex due effect with results contribute understanding

Language: Английский

Social Isolation Induces Addictive Behavior and Increased Dopamine Release in the Nucleus Accumbens in Response to Stimulation of the Positive Reinforcing Zone DOI

S. S. Pyurveev,

А. А. Лебедев,

V. V. Sizov

et al.

Neuroscience and Behavioral Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Language: Английский

Citations

0
Exploring the antidepressant potential of Ruta chalepensis essential oil in socially isolated rats: Behavioural and neurochemical insights DOI Creative Commons
Hala Attia, Hanan Y. Aati,

Razan M Babtin

et al.

Arabian Journal of Chemistry, Journal Year: 2025, Volume and Issue: 0, P. 1 - 8

Published: March 11, 2025

Language: Английский

Citations

0
Pharmacological agents and injection stress, but not social isolation, alter cognitive judgement bias in the mouse touchscreen operant chamber DOI Creative Commons

Ashlyn Y Hersey,

Paul A. S. Sheppard, Ryan Kim

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 21, 2025

Cognitive judgement bias (CJB) refers to the interpretation of ambiguous stimuli in a negative (pessimistic) or positive (optimistic) way. Negative CJB is observed depression and anxiety, conditions that burden affected individuals their caregivers. Pre-clinical animal research key understanding developing therapies for affective anxiety disorders, so translationally relevant test would be useful addition existing pre-clinical rodent touchscreen battery. Here, task mouse operant chambers was adapted validated using pharmacological agents, bupropion tetrabenazine, known induce CJB, respectively. Further, shifts were following an injection procedure (handling intraperitoneal with saline solution), demonstrating sensitivity task. Interestingly, whereas social isolation has been linked changes state humans, 8 weeks single-housing mice did not alter but anxiety-like behaviour open field. Collectively, these results present assess mice, which will facilitate future explorations into underlying neurobiology potential treatment disorders.

Language: Английский

Citations

0
Social isolation and post‐weaning environmental enrichment effects on rat emotional behavior and serotonergic system DOI

Roxana Patrícia Bezerra da Silva,

Isabeli Lins Pinheiro,

Regina Katiuska Bezerra da Silva

et al.

International Journal of Developmental Neuroscience, Journal Year: 2024, Volume and Issue: 84(4), P. 265 - 280

Published: March 25, 2024

Social isolation (SI) is related to adverse neurobehavioral effects and neurochemical changes when it occurs early in development. On the other hand, environmental enrichment (EE) associated with a reduction anxiety-like depression-like behavior, as well an increase serotonin (5-HT) levels prefrontal cortex hippocampus rodents. This study systematically reviewed of SI EE on emotional behavior serotonergic system components rats after weaning. Primary experimental studies that used subgroups subjected SI, EE, normal social conditions weaning were considered eligible. Studies transgenic rodents, ex vivo studies, vitro human research, or silico ineligible. Two authors completed searches Medline/PubMed, LILACS, Scopus, Web Science, EMBASE, Open Gray. The Kappa index was calculated assess agreement between reviewers quality. results showed animals exposed better adaptation new environment. Furthermore, increased 5-HT Thus, appears during critical period development may reduce anxiety/depression-like behaviors, long-term neurotransmitter response.

Language: Английский

Citations

3
Sex-specific behavioral, cardiac, and neuroendocrine responses to repeated witness social stress in adult rats DOI Creative Commons
Margherita Barbetti, Andrea Sgoifo, Luca Carnevali

et al.

Physiology & Behavior, Journal Year: 2024, Volume and Issue: 287, P. 114702 - 114702

Published: Sept. 25, 2024

In humans, sex disparities exist in the prevalence of social stress-related disorders, yet our understanding predisposing factors and underlying mechanisms is still elusive. Also at preclinical level, investigation differences stress responses limited. this study, adult male female wild-type Groningen rats were repeatedly exposed to witness defeat (WS) assess sex-specific behavioral, neuroendocrine, cardiac same paradigm. Male bore an aggressive episode between two males for nine consecutive days or a control (CTR) procedure. Stress-related parameters assessed correspondence first last WS/CTR exposure also during subsequent context alone absence defeat. During WS, both sexes displayed larger amounts burying behavior smaller rearing grooming behaviors, but with greater extent witnesses. Cardiac autonomic WS similar sexes, only females higher plasma corticosterone levels after compared CTRs, had increase than witnesses upon repeated WS. Exposure (i.e., without presence resident rat) elicited amount more pronounced persistent tachycardic history Our findings suggest sex-disparities response multiple cardiac, neuroendocrine levels, highlighting utility paradigm investigating pathophysiological vulnerabilities pathologies.

Language: Английский

Citations

3
Natural variations of adolescent neurogenesis and anxiety predict the hierarchical status of adult inbred mice DOI Creative Commons

Fabio Grieco,

Atik Balla,

Thomas Larrieu

et al.

EMBO Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Abstract Hierarchy provides a survival advantage to social animals in challenging circumstances. In mice, dominance is associated with trait anxiety which regulated by adult hippocampal neurogenesis. Here, we test whether adolescent neurogenesis may regulate behavior adulthood. We observe that individuals higher and lower levels of prior the formation new group become dominants, suggesting baseline predicts hierarchical status. This phenotype persists beyond hierarchy stabilization. Experimentally reducing stabilization group-housed males increases probability mice dominant anxiety. Finally, when innate assessed socially isolated anxiety-matched animals, impaired display status toward strangers. Together, these results indicate regulates situational along anxiety-related behavior. These provide framework study mechanisms underlying dysregulation psychiatric diseases related

Language: Английский

Citations

0
A single reminder trial updates fear memory and affects extinction in rats housed under different living conditions DOI
И. В. Павлова,

Nadezda Broshevitskaya,

Grigory Grigoryan

et al.

Learning and Motivation, Journal Year: 2025, Volume and Issue: 89, P. 102098 - 102098

Published: Jan. 31, 2025

Language: Английский

Citations

0
Social isolation induces sexually aggressive behaviour in male Wistar rats DOI Creative Commons

Mbiydzenyuy Elvis Ngala,

Sian Hemmings, Jacqueline S. Womersley

et al.

BMC Neuroscience, Journal Year: 2025, Volume and Issue: 26(1)

Published: Feb. 26, 2025

Abstract Background Sexual violence, a pervasive global issue, significantly impacts individuals and societies, necessitating deeper understanding of its underlying biological mechanisms. This study aimed to elucidate the role stress-induced dysregulation hypothalamus-pituitary-adrenocortical axis in sexual aggression male Wistar rats. Employing paradigm, we investigated effects social isolation on aggression, anxiety-like behaviour, neurochemistry virgin adult Results The results showed that escalated aggressive behaviours induced responses test revealed socially isolated males exhibited heightened towards non-receptive females. Neurochemical analyses indicated significant alterations key markers, such as corticotrophin-releasing hormone, oxytocin, arginine vasopressin, correlating with observed behavioural changes. Gene expression findings, particularly oxytocin receptor (OXTR) vasopressin 1 A (AVPR1A) genes. Social duration behaviour prior influenced OXTR hippocampus AVPR1A both prefrontal cortex hippocampus, highlighting complex interplay between environmental stressors, neurochemical responses, gene manifestation behaviour. Conclusions underscores critical impact stress providing valuable insights into possible neurobiological underpinnings violence. Understanding these mechanisms is crucial for developing effective interventions mitigate consequences aggression.

Language: Английский

Citations

0
From memory disorders to the development of depression: a system approach DOI

Grigory Grigoryan

Biosystems, Journal Year: 2025, Volume and Issue: unknown, P. 105440 - 105440

Published: March 1, 2025

Language: Английский

Citations

0
The influence of long-term housing in enriched environment on behavior of normal rats and subjected to neonatal pro-inflammatory challenge DOI Creative Commons
И. В. Павлова,

Nadezda Broshevitskaya,

М. И. Зайченко

et al.

Brain Behavior & Immunity - Health, Journal Year: 2023, Volume and Issue: 30, P. 100639 - 100639

Published: May 24, 2023

It is well known that neonatal pro-inflammatory challenge (NPC) acquire a predisposition to the development of number neuropsychiatric diseases: depression, anxiety disorders, autism, attention deficit hyperactivity disorder. Symptoms these diseases can manifest themselves in adulthood and adolescent after repeated exposure negative influences. Preventing consequences NPC one main tasks for researchers. The an enriched environment (EE) was shown have anxiolytic, anti-depressive, pro-cognitive effects. present work aimed investigate effects long-term EE on anxious-depressive conditioned fear behavior normal male female rats subjected NPC. induced by subcutaneous administration lipopolysaccharide (LPS, 50 μg/kg) 3d 5th PNDs. control animals received saline (SAL). were placed from 25 120 PND. Animals housed standard conditions (STAND) served as controls. In adult STAND groups, LPS did not affect anxiety, depressive-like fear. increased motor search activity males females. open field, reduced SAL groups females compared animals. elevated plus maze, decreased only group. sucrose preference test, change consumption while, forced swimming both groups. enrichment contextual but group, cue corticosterone reactivity stress basal level IL-1beta blood serum SAL-EE Thus, males, females, Although behaviors prevented beneficial opposing dependent sex type testing.

Language: Английский

Citations

7