Potential Neuroprotective Effect of Melatonin in the Hippocampus of Male BTBR Mice DOI Open Access
Matteo Bonetti, Lorena Giugno, Elisa Borsani

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1652 - 1652

Published: May 28, 2024

Autism spectrum disorder (ASD) is a neurodevelopmental identified by impairments in common social interactions and repetitive behaviors. In ASD patients, substantial morphological alterations have been observed the hippocampus, which represents an important region for development of skills. Melatonin, commonly found many foods plants, also produced pineal gland. This indolamine, known to regulate circadian rhythm, shows antioxidant anti-inflammatory properties. We therefore hypothesized that melatonin may reduce oxidative stress inflammation hippocampus patients. explored our hypothesis using BTBR mouse, well-regarded murine transgenic model ASD. Immediately after weaning, male C57BL/6 mice underwent 8-week treatment with or vehicle. Later, through immunohistochemistry immunoblotting analysis we evaluated overall expression cellular localization Nrf2 SOD1, two enzymes involved response. Similarly, NLRP3 NFkB, mediators inflammation, GAD67, enzyme responsible synthesis GABA. Ultimately, addressed melatonin’s potential iron metabolism DAB-enhanced Perls reaction assay. Results showed modulating analyzed markers mice, suggesting neuroprotective effect

Language: Английский

Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets DOI Creative Commons
Meng Zhang, Qian Liu, Hui Meng

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 8, 2024

Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following ischemia, exacerbating the initial tissue damage. The limited understanding of intricate mechanisms underlying I/R hinders development effective therapeutic interventions. Wnt signaling pathway exhibits extensive crosstalk with various other pathways, forming a network system pathways involved in injury. This review article elucidates signaling, as well complex interplay between and including Notch, phosphatidylinositol 3-kinase/protein kinase B, transforming growth factor-β, nuclear factor kappa, bone morphogenetic protein, N-methyl-D-aspartic acid receptor-Ca 2+ -Activin A, Hippo-Yes-associated toll-like receptor 4/toll-interleukine-1 domain-containing adapter-inducing interferon-β, hepatocyte factor/mesenchymal-epithelial transition factor. In particular, we delve into their respective contributions to key pathological processes, apoptosis, inflammatory response, oxidative stress, extracellular matrix remodeling, angiogenesis, cell hypertrophy, fibrosis, ferroptosis, neurogenesis, blood-brain barrier damage Our comprehensive analysis reveals that activation canonical promotes organ recovery, while non-canonical exacerbates Moreover, explore novel approaches based on these mechanistic findings, incorporating evidence from animal experiments, current standards, clinical trials. objective this is provide deeper insights roles its I/R-mediated processes dysfunction, facilitate innovative agents for

Language: Английский

Citations

165
The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks DOI Creative Commons
Jie Li, Yuchen Jia,

Yi-xuan Ding

et al.

International Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 19(9), P. 2756 - 2771

Published: Jan. 1, 2023

Ferroptosis is an iron-driven cell death modality characterized by iron accumulation and excessive lipid peroxidation.Ferroptosis closely related to mitochondrial function, as indicated studies showing that dysfunction damage promote oxidative stress, which in turn induces ferroptosis.Mitochondria play crucial roles cellular homeostasis, abnormalities their morphology function are associated with the development of many diseases.Mitochondria highly dynamic organelles, stability maintained through a series regulatory pathways.Mitochondrial homeostasis dynamically regulated, mainly via key processes such fission, fusion mitophagy; however, prone dysregulation.Mitochondrial fission mitophagy intimately ferroptosis.Therefore, investigations into regulation during ferroptosis important provide better understanding disease.In this paper, we systematically summarized changes ferroptosis, in-depth mechanism underlying corresponding reference for treatment diseases.

Language: Английский

Citations

98
Pharmacological Inhibition of Ferroptosis as a Therapeutic Target for Neurodegenerative Diseases and Strokes DOI Creative Commons
Yumin Wang, Shuang Wu, Qiang Li

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(24)

Published: June 21, 2023

Emerging evidence suggests that ferroptosis, a unique regulated cell death modality is morphologically and mechanistically different from other forms of death, plays vital role in the pathophysiological process neurodegenerative diseases, strokes. Accumulating supports ferroptosis as critical factor diseases strokes, pharmacological inhibition therapeutic target for these diseases. In this review article, core mechanisms are overviewed roles strokes described. Finally, emerging findings treating through This demonstrates by bioactive small-molecule compounds (ferroptosis inhibitors) could be effective treatments highlights potential promising avenue used to prevent article will shed light on developing novel regimens slow down progression future.

Language: Английский

Citations

83
Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases DOI Creative Commons
Yumin Wang, Jing Hu, Shuang Wu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Dec. 10, 2023

Abstract Ferroptosis, a unique modality of cell death with mechanistic and morphological differences from other modes, plays pivotal role in regulating tumorigenesis offers new opportunity for modulating anticancer drug resistance. Aberrant epigenetic modifications posttranslational (PTMs) promote resistance, cancer progression, metastasis. Accumulating studies indicate that can transcriptionally translationally determine vulnerability to ferroptosis functions as driver nervous system diseases (NSDs), cardiovascular (CVDs), liver diseases, lung kidney diseases. In this review, we first summarize the core molecular mechanisms ferroptosis. Then, roles processes, including histone PTMs, DNA methylation, noncoding RNA regulation such phosphorylation, ubiquitination, SUMOylation, acetylation, ADP-ribosylation, are concisely discussed. The PTMs genesis cancers, NSD, CVDs, well application PTM modulators therapy these then discussed detail. Elucidating mediated by will facilitate development promising combination therapeutic regimens containing or PTM-targeting agents inducers be used overcome chemotherapeutic resistance could prevent addition, highlight potential approaches chemoresistance halt

Language: Английский

Citations

77
The mechanism of ferroptosis and its related diseases DOI Creative Commons
Shijian Feng, Dan Tang, Yichang Wang

et al.

Molecular Biomedicine, Journal Year: 2023, Volume and Issue: 4(1)

Published: Oct. 16, 2023

Abstract Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation lipid peroxides, provides novel avenue for delving into intersection metabolism, oxidative stress, and disease pathology. We have witnessed mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, traumatic tissue injuries. By unraveling intricate underpinnings molecular machinery, contributors, signaling conduits, regulatory networks governing researchers aim bridge gap between intricacies this unique mode multifaceted implications health disease. In light rapidly advancing landscape ferroptosis research, we present comprehensive review aiming at extensive in origins progress human diseases. This concludes careful analysis potential treatment approaches carefully designed either inhibit or promote ferroptosis. Additionally, succinctly summarized therapeutic targets compounds that hold promise targeting within various facet underscores burgeoning possibilities manipulating as strategy. summary, enriched insights both investigators practitioners, while fostering an elevated comprehension latent translational utilities. revealing basic processes investigating possibilities, crucial resource scientists medical aiding deep understanding effects situations.

Language: Английский

Citations

62
The role of mitochondrial dynamics in cerebral ischemia-reperfusion injury DOI Open Access
Jie Huang, Lei Chen,

Zi‐Meng Yao

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114671 - 114671

Published: April 8, 2023

Stroke is one of the leading causes death and long-term disability worldwide. More than 80 % strokes are ischemic, caused by an occlusion cerebral arteries. Without question, restoration blood supply as soon possible first therapeutic strategy. Nonetheless paradoxically, reperfusion can further aggravate injury through a series reactions known ischemia-reperfusion (CIRI). Mitochondria play vital role in promoting nerve survival neurological function recovery mitochondrial dysfunction considered characteristics CIRI. Neurons often die due to oxidative stress imbalance energy metabolism following CIRI, there strong association with dysfunction. Altered dynamics reaction stress. Mitochondrial refers maintenance integrity, distribution, size mitochondria well their ability resist external stimuli continuous cycle fission fusion. Therefore, improving means treating This review discusses relationship between CIRI emphasizes potential approach improve prognosis

Language: Английский

Citations

44
Association of composite dietary antioxidant index with prevalence of stroke: insights from NHANES 1999-2018 DOI Creative Commons

Tian-Qi Teng,

Jing Liu, Fangfang Hu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 8, 2024

Background There is a growing acknowledgment of the potential influence antioxidative effects resulting from dietary decisions on occurrence stroke. The objective this study was to elucidate correlation between composite antioxidant index (CDAI) and incidence stroke in general population United States. Methods We gathered cross-sectional data encompassing 40,320 participants National Health Nutrition Examination Survey (NHANES) spanning years 1999 2018. Employing weighted multivariate logistic regression, we assessed CDAI stroke, while also investigating nonlinear relationships through restricted cubic spline (RCS) regression. Further, intake components were then incorporated into predictive nomogram model, subsequently evaluated for its discriminatory prowess risk assessment using receiver operating characteristic (ROC) curve. Results Post-adjustment confounding variables, found that higher score associated with decreased odds ratio (OR) [95% CI] associating prevalence 0.96 [0.94-0.98] (P< 0.001). Moreover, adjusted OR across ascending quartiles stood at 0.90 [0.74-1.09], 0.74 [0.60-0.91], 0.61 [0.50-0.76] compared reference quartile, respectively. RCS analysis indicated yet negative constructed based antioxidants, exhibited significant capacity risk, boasting an area under curve (AUC) 77.4% (76.3%–78.5%). Conclusion Our investigation ascertained relationship within broader American population. However, given inherent limitations design, further comprehensive research imperative establish causative nature association.

Language: Английский

Citations

24
Targeting Ferroptosis as a Promising Therapeutic Strategy for Ischemia-Reperfusion Injury DOI Creative Commons
Yihang Pan, Xueke Wang, Xiwang Liu

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(11), P. 2196 - 2196

Published: Nov. 6, 2022

Ischemia-reperfusion (I/R) injury is a major challenge in perioperative medicine that contributes to pathological damage various conditions, including ischemic stroke, myocardial infarction, acute lung injury, liver transplantation, kidney and hemorrhagic shock. I/R often irreversible, current treatments for are limited. Ferroptosis, type of regulated cell death characterized by the iron-dependent accumulation lipid hydroperoxides, has been implicated multiple diseases, injury. Emerging evidence suggests ferroptosis can serve as therapeutic target alleviate pharmacological strategies targeting have developed models. Here, we systematically summarize recent advances research on provide comprehensive analysis ferroptosis-regulated genes investigated context I/R, well applications regulators, insights into developing this devastating disease.

Language: Английский

Citations

66
The role of ferroptosis and its mechanism in ischemic stroke DOI
Xiaodan Hu, Yutong Bao, Man Li

et al.

Experimental Neurology, Journal Year: 2023, Volume and Issue: 372, P. 114630 - 114630

Published: Dec. 4, 2023

Language: Английский

Citations

35
SIRT5 Regulates Ferroptosis through the Nrf2/HO-1 Signaling Axis to Participate in Ischemia-Reperfusion Injury in Ischemic Stroke DOI
Jian Li, Wei Gao,

Zhaoming Song

et al.

Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(4), P. 998 - 1007

Published: Jan. 3, 2024

Language: Английский

Citations

15