Breaking barriers: Smart vaccine platforms for cancer immunomodulation DOI Creative Commons
Mohammad Mahmoudi Gomari,

Taha Ghantabpour,

Nima Pourgholamamiji

et al.

Cancer Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract Despite significant advancements in cancer treatment, current therapies often fail to completely eradicate malignant cells. This shortfall underscores the urgent need explore alternative approaches such as vaccines. Leveraging immune system's natural ability target and kill cells holds great therapeutic potential. However, development of vaccines is hindered by several challenges, including low stability, inadequate response activation, immunosuppressive tumor microenvironment, which limit their efficacy. Recent progress various fields, click chemistry, nanotechnology, exosome engineering, neoantigen design, offer innovative solutions these challenges. These achievements have led emergence smart vaccine platforms (SVPs), integrate protective carriers for messenger ribonucleic acid (mRNA) with functionalization strategies optimize targeted delivery. Click chemistry further enhances SVP performance improving encapsulation mRNA antigens facilitating precise delivery review highlights latest developments technologies therapy, exploring both opportunities challenges advancing transformative approaches.

Language: Английский

Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications DOI
Jagannath Mondal, Shameer Pillarisetti, Vijayabhaskarreddy Junnuthula

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 353, P. 1127 - 1149

Published: Dec. 26, 2022

Language: Английский

Citations

170
Exosomes: A potential tool for immunotherapy of ovarian cancer DOI Creative Commons

Xiangjin Gong,

Hao Chi,

Dorothee Franziska Strohmer

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 18, 2023

Ovarian cancer is a malignant tumor of the female reproductive system, with very poor prognosis and high mortality rates. Chemotherapy radiotherapy are most common treatments for ovarian cancer, unsatisfactory results. Exosomes subpopulation extracellular vesicles, which have diameter approximately 30–100 nm secreted by many different types cells in various body fluids. highly stable effective carriers immunotherapeutic drugs. Recent studies shown that exosomes involved cellular responses microenvironment, influencing development therapeutic efficacy exhibiting dual roles inhibiting promoting development. also contain variety genes related to immunotherapy could be potential biomarkers diagnosis prognosis. Undoubtedly, great field immunotherapy. However, translation this idea clinic has not occurred. Therefore, it important understand how used regulate progression. In review, we summarize fluids mechanisms influence response. We discuss prospects clinical application exosome-based cancer.

Language: Английский

Citations

57
The next-generation DNA vaccine platforms and delivery systems: advances, challenges and prospects DOI Creative Commons
Bowen Lu,

Jing Ming Lim,

Boyue Yu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 1, 2024

Vaccines have proven effective in the treatment and prevention of numerous diseases. However, traditional attenuated inactivated vaccines suffer from certain drawbacks such as complex preparation, limited efficacy, potential risks others. These limitations restrict their widespread use, especially face an increasingly diverse range With ongoing advancements genetic engineering vaccines, DNA emerged a highly promising approach both diseases acquired While several demonstrated substantial success animal models diseases, challenges need to be addressed before application human subjects. The primary obstacle lies absence optimal delivery system, which significantly hampers immunogenicity vaccines. We conduct comprehensive analysis current status by focusing on viral non-viral systems, they play crucial roles exploration novel provide evaluation strengths weaknesses based our critical assessment. Additionally, review summarizes most recent breakthroughs pre-clinical clinical studies, highlighting for further trials this rapidly evolving field.

Language: Английский

Citations

47
Engineered tumor cell-derived vaccines against cancer: The art of combating poison with poison DOI Creative Commons
Xinyi Zhang,

Hengqing Cui,

Wenjun Zhang

et al.

Bioactive Materials, Journal Year: 2022, Volume and Issue: 22, P. 491 - 517

Published: Oct. 26, 2022

Tumor vaccination is a promising approach for tumor immunotherapy because it presents high specificity and few side effects. However, vaccines that contain only single antigen can allow immune system evasion by variants. antigens are complex heterogeneous, identifying uniformly expressed cells challenging. Whole produce comprehensive trigger extensive tumor-specific responses. Therefore, an ideal source of vaccines. A better understanding cell-derived their characteristics, along with the development new technologies delivery, help improve vaccine design. In this review, we summarize recent advances in cancer highlight different types engineered approaches, mechanisms, administration methods, future perspectives. We discuss vaccines, including whole cell components, extracellular vesicles, membrane-encapsulated nanoparticles. multiple induce potent they should be to overcome limitations such as insufficient immunogenicity weak targeting. The genetic chemical engineering greatly enhance targeting, intelligence, functionality, thereby realizing stronger Further materials science, biomedicine, oncology facilitate clinical translation

Language: Английский

Citations

47
Environmental pollutants and exosomes: A new paradigm in environmental health and disease DOI
Afsaneh Javdani-Mallak,

Iman Salahshoori

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 925, P. 171774 - 171774

Published: March 18, 2024

Language: Английский

Citations

15
Engineering customized nanovaccines for enhanced cancer immunotherapy DOI Creative Commons

JinYu Guo,

Changhua Liu, Zhaoyang Qi

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 36, P. 330 - 357

Published: March 11, 2024

Nanovaccines have gathered significant attention for their potential to elicit tumor-specific immunological responses. Despite notable progress in tumor immunotherapy, nanovaccines still encounter considerable challenges such as low delivery efficiency, limited targeting ability, and suboptimal efficacy. With an aim of addressing these issues, engineering customized through modification or functionalization has emerged a promising approach. These tailored not only enhance antigen presentation, but also effectively modulate immunosuppression within the microenvironment. Specifically, they are distinguished by diverse sizes, shapes, charges, structures, unique physicochemical properties, along with ligands. features facilitate lymph node accumulation activation/regulation immune cells. This overview bespoke underscores both prophylactic therapeutic applications, offering insights into future development role cancer immunotherapy.

Language: Английский

Citations

13
Extracellular vesicles associated microRNAs: Their biology and clinical significance as biomarkers in gastrointestinal cancers DOI
Yuan Li,

Silei Sui,

Ajay Goel

et al.

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 99, P. 5 - 23

Published: Feb. 1, 2024

Language: Английский

Citations

12
Extracellular Vesicles: A Novel Mode of Viral Propagation Exploited by Enveloped and Non-Enveloped Viruses DOI Creative Commons
Shruti Chatterjee, Ramina Kordbacheh, Jon Sin

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(2), P. 274 - 274

Published: Jan. 28, 2024

Extracellular vesicles (EVs) are small membrane-enclosed structures that have gained much attention from researchers across varying scientific fields in the past few decades. Cells secrete diverse types of EVs into extracellular milieu which include exosomes, microvesicles, and apoptotic bodies. These play a crucial role facilitating intracellular communication via transport proteins, lipids, DNA, rRNA, miRNAs. It is well known number viruses hijack several cellular pathways involved EV biogenesis to aid their replication, assembly, egress. On other hand, can also trigger host antiviral immune responses by carrying immunomodulatory molecules viral antigens on surface. Owing this intricate relationship between viruses, intriguing studies identified various EV-mediated infections interrogated how alter overall spread longevity. This review provides comprehensive overview EV-virus relationship, details modes context clinically relevant enveloped non-enveloped viruses.

Language: Английский

Citations

10
Engineered and Mimicked Extracellular Nanovesicles for Therapeutic Delivery DOI Creative Commons
Véréna Poinsot, Nathalie Pizzinat, Varravaddheay Ong‐Meang

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(7), P. 639 - 639

Published: April 6, 2024

Exosomes are spherical extracellular nanovesicles with an endosomal origin and unilamellar lipid-bilayer structure sizes ranging from 30 to 100 nm. They contain a large range of proteins, lipids, nucleic acid species, depending on the state vesicle (EV)-secreting cell. EVs’ function is encapsulate part EV-producing cell content, transport it through biological fluids targeted recipient, deliver their cargos specifically within aimed recipient cells. Therefore, exosomes considered be potential drug-delivery systems that can stably cargo into Various cell-derived produced for medical issues, but use therapeutic purposes still faces several problems. Some these difficulties avoided by resorting hemisynthetic approaches. We highlight here uses alternative exosome-mimes involving cell-membrane coatings artificial nanocarriers or hybridization between liposomes. also detail drug-loading strategies deployed make them drug-carrier summarize ongoing clinical trials exosome-like structures. Finally, we open questions before considering disposals confident delivery.

Language: Английский

Citations

9
The hidden messengers: cancer associated fibroblasts—derived exosomal miRNAs as key regulators of cancer malignancy DOI Creative Commons
Zixuan Gou, Jiannan Li, Jianming Liu

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: April 17, 2024

Cancer-associated fibroblasts (CAFs), a class of stromal cells in the tumor microenvironment (TME), play key role controlling cancer cell invasion and metastasis, immune evasion, angiogenesis, resistance to chemotherapy. CAFs mediate their activities by secreting soluble chemicals, releasing exosomes, altering extracellular matrix (ECM). Exosomes contain various biomolecules, such as nucleic acids, lipids, proteins. microRNA (miRNA), 22–26 nucleotide non-coding RNA, can regulate cellular transcription processes. Studies have shown that miRNA-loaded exosomes secreted engage regulatory communication networks with other TME constituents. This study focused on roles CAF-derived exosomal miRNAs generating malignant characteristics, including modulation, growth, migration invasion, epithelial-mesenchymal transition (EMT), treatment resistance. thoroughly examines miRNA’s dual promoting suppressing cancer. Thus, changes be used biomarkers for diagnosis prognosis patients, specificity develop newer therapies. review also discusses pressing problems require immediate attention, aiming inspire researchers explore more novel avenues this field.

Language: Английский

Citations

9