Recent Advances in Drug Delivery and Formulation,
Journal Year:
2024,
Volume and Issue:
18(4), P. 262 - 275
Published: Aug. 7, 2024
:
The
buccal
cavity,
also
known
as
the
oral
is
a
complex
anatomical
structure
that
plays
crucial
role
in
various
physiological
processes.
It
serves
gateway
to
digestive
system
and
facilitates
initial
stages
of
food
digestion
absorption.
However,
its
significance
extends
beyond
mere
it
presents
promising
route
for
drug
delivery,
particularly
brain.
Transferosomes
are
lipid-based
vesicles
have
gained
significant
attention
field
delivery
due
their
unique
properties.
These
composed
phospholipids
form
bilayer
structures
capable
encapsulating
both
hydrophilic
lipophilic
drugs.
Strategies
development
transferosomes
brain
emerged
avenues
pharmaceutical
research.
This
review
aims
explore
approaches
challenges
associated
with
harnessing
potential
means
enhancing
By
understanding
function
tissue
transferosomes,
researchers
can
develop
effective
formulation
methods
characterization
techniques
optimize
delivery.
Furthermore,
strategic
success
stories
transferosome
highlighted,
showcasing
inspiring
examples
demonstrate
revolutionize
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: April 28, 2025
Urine-based
therapy,
an
ancient
practice,
has
been
utilized
across
numerous
civilizations
to
address
a
wide
range
of
ailments.
Urine
was
considered
priceless
resource
in
traditional
therapeutic
applications
due
its
reported
medicinal
capabilities.
While
the
utilization
urine
treatment
is
contentious
and
lacks
significant
support
from
modern
healthcare,
discovery
urine-derived
stem
cells
(UDSCs)
introduced
promising
avenue
for
cell-based
therapy.
UDSCs
offer
noninvasive
easily
repeatable
collection
method,
making
them
practical
viable
option
applications.
Research
shown
that
contribute
organ
preservation
by
promoting
revascularization
decreasing
inflammatory
reactions
many
diseases
conditions.
This
review
will
outline
contemporary
status
research
explore
their
potential
both
fundamental
science
medical
practice.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
168, P. 115805 - 115805
Published: Oct. 31, 2023
Cannabidiol
(CBD),
a
cannabinoid
that
does
not
create
psychoactive
activities,
has
been
identified
as
having
multitude
of
therapeutic
benefits.
This
study
delves
into
the
chemical
properties,
pharmacokinetics,
safety
and
toxicity,
pharmacological
effects,
most
importantly,
association
between
potential
CBD
nuclear
factor
erythroid
2-related
2
(Nrf2)
signaling
pathway.
The
relationship
Nrf2
is
closely
linked
to
certain
proteins
are
associated
with
cardiovascular
dysfunctions,
cancers,
neurodegenerative
conditions.
Specifically,
connected
initiation
progression
diverse
health
issues,
including
nephrotoxicity,
bladder-related
diseases,
oral
mucositis,
obesity,
myocardial
injury
angiogenesis,
skin-related
inflammations,
psychotic
disorders,
neuropathic
pain,
Huntington's
disease,
Alzheimer's
Parkinson's
neuroinflammation,
Amyotrophic
Lateral
Sclerosis,
Multiple
Sclerosis.
zone
great
interest
in
medical
field,
it
significantly
impact
treatment
prevention
wide-ranging
Additional
investigation
necessary
entirely
apprehend
mechanisms
underlying
this
crucial
interplay
develop
effective
interventions.
International Journal of Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
660, P. 124370 - 124370
Published: June 19, 2024
Limited
attempts
have
been
made
previously
to
develop
high-loading
CBD
inhalable
powders,
which
are
essential
for
high
dose
delivery.
Therefore,
this
study
aimed
and
characterise
powders
with
≥
95
%
w/w
by
wet
ball
milling.
The
effects
of
magnesium
stearate
(2
5
%)
inhaler
resistance
(low-resistance
high-resistance
RS01
inhalers)
on
aerosol
performance
were
also
compared.
Wet
milling
produced
>
50
production
yield.
milled
particles
showed
irregular
shapes.
crystalline
minimal
amorphous
content,
low
residual
solvent
level
(<1%),
moisture
sorption
(<4%).
Magnesium
improved
both
the
emitted
fine
particle
fractions.
aerodynamic
size
distribution
formulations
differed
between
low-resistance
inhalers.
latter
decreased
throat
deposition
but
increased
retention.
dissolution
profiles
that
all
three
released
steadily
plateaued
at
30
min.
best
scenario
was
dispersed
from
inhaler,
showing
highest
FPF
lowest
deposition.
This
combination
may
be
tested
in
vivo
future
investigate
its
pharmacokinetic
profile.
Cannabis and Cannabinoid Research,
Journal Year:
2023,
Volume and Issue:
9(5), P. 1312 - 1325
Published: Oct. 20, 2023
Background:
There
is
an
urgent
need
for
novel
therapies
to
treat
Alzheimer's
disease.
Among
others,
the
use
of
cannabinoids
such
as
delta-9-tetrahydrocannabinol
(THC)
and
cannabidiol
(CBD)
has
been
proposed
a
putative
approach
based
on
their
anti-inflammatory
effects.
Methods:
The
present
work
was
designed
explore
effects
chronic
(28
days)
treatment
with
low
doses
cannabinoids:
CBD
(0.273
mg/kg),
THC
(0.205
mg/kg)
or
combination
both
(CBD:THC;
0.273
mg/kg:0.205
in
5xFAD
mouse
model
AD.
Results:
Our
data
revealed
that
THC-treated
mice
(but
not
other
groups)
exhibited
anxiogenic
depressant-like
behavior.
A
significant
improvement
spatial
memory
observed
only
CBD:THC-treated
group.
Interestingly,
all
cannabinoid-treated
groups
showed
significantly
increased
cortical
levels
insoluble
form
beta
amyloid
1-42.
These
were
accompanied
by
changes
molecular
parameters
inflammation
at
mRNA
protein
level.
Conclusions:
reveal
differential
chronic,
low-dose
point
role
these
processing
peptides
brains
mice.
Journal of Ayurveda and Integrative Medicine,
Journal Year:
2024,
Volume and Issue:
15(3), P. 100911 - 100911
Published: May 1, 2024
Natural
bioactives
possess
a
wide
range
of
chemical
structures
that
can
exert
plethora
pharmacological
and
toxicological
actions,
resulting
in
neuroprotection
or
neurotoxicity.
These
pharmacodynamic
properties
positively
negatively
impact
human
animal
global
healthcare.
Remarkably,
Ayurvedic
botanical
Cannabis
has
been
used
worldwide
by
different
ethnicities
religions
for
spiritual,
commercial,
recreational,
nutraceutical,
cosmeceutical,
medicinal
purposes
centuries.
Cannabis-based
congeners
have
approved
the
United
States
America's
(USA)
Food
&
Drug
Administration
(FDA)
other
law
agencies
various
therapeutic
purposes.
Surprisingly,
strict
laws
associated
with
possessing
cannabis
products
mitigated
multiple
states
USA
across
globe
recreational
use.
This
consequently
led
to
radical
escalation
exposure
cannabis-related
substances
abuse.
However,
there
is
lacuna
literature
on
acute
chronic
effects
its
neuropathologies.
Moreover,
post-COVID
era,
drastic
increase
incidence
prevalence
numerous
neuropathologies,
leading
increased
morbidity
mortality.
There
an
impending
necessity
safe,
economically
viable,
multipotent,
natural
bioactive
prevent
treat
The
ayurvedic
herb,
one
oldest
botanicals
known
humans
widely
used.
comprehensive
effect
neuropathologies
not
well
established.
Hence,
this
review
presents
