Egyptian Journal of Desert Research,
Journal Year:
2024,
Volume and Issue:
74(1), P. 129 - 147
Published: May 25, 2024
The
purpose
of
this
study
was
to
compare
the
biological
effects
as
antimicrobial
and
antitumor
activity
bioactive
ingredients
two
plants
Iphonia
mucronata
Conyza
dioscorides
which
belong
Asteraceae
family.
I.
EtOAc
extract
exhibited
promising
against
HELA
(cervical),
PC-3
(prostate),
HEP-2
(larynx)
carcinoma
cell
lines
with
IC50
values
24.60,
26.57
39.06
μg/ml,
respectively.
While
C.
showed
weak
moderate
same
lines.
MeOH
extracts
activity,
also
antibacterial
Proteus
vulgaris,
Bacillus
subtilis
Escherichia
coli,
total
active
constituents
both
revealed
higher
concentrations
than
all
components
except
alkaloid
content.
phenolic,
flavonoid,
were
in
while
saponins
content
whereas
tannins
similar
for
plants.
major
phenolic
acids
flavonoid
compounds
investigated
using
HPLC
caffeic,
ferulic
acid,
naringin,
luteolin
mucronata.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Nov. 8, 2024
This
study
aimed
to
investigate
the
effect
of
selected
compounds
from
group
triterpene
sapogenins
on
model
phosphatidylcholine
membranes.
Two
types
biological
membrane
systems
were
used
in
work,
i.e.,
liposomes
(microelectrophoresis
method)
and
spherical
bilayers
(interfacial
tension
method).
Each
was
modified
with
tested
sapogenin
compounds,
change
their
physicochemical
electrical
parameters
analyzed.
Parameters
characterizing
equilibrium
1,2-dipalmitoyl-sn-glycero-3-phosphocholine
(DPPC)-oleanolic
acid
(OA)
DPPC-asiatic
(AA)
determined).
Based
Young-Laplace
equation,
interfacial
tensions
lipid
measured.
The
formation
1:1
complexes
assumed
DPPC-OA
DPPC-AA
systems,
interactions
formed
calculated.
Microelectrophoresis
surface
charge
density
These
values
obtained
electrophoretic
mobility
data
using
Smoluchowsky's
equation.
influence
pH
electrolyte
solution
composition
membranes
investigated.
results
indicate
that
modifying
DPPC
sapogenins,
both
OA
AA,
causes
changes
shifts
isoelectric
point.
Data
presented
this
through
mathematical
derivation
confirmed
experimentally,
are
great
importance
for
interpreting
phenomena
occurring
A
quantitative
description
equilibria
between
lets
us
understand
processes
surface.
particularly
significant
standpoint
cell
functioning.
Phosphatidylcholine-sapogenin
modulate
a
range
properties
membranes,
they
important
course
multiple
involving
living
(e.g.,
transport
mechanism).
