Abordagem geral das características da Síndrome de Cushing

Revista Eletrônica Acervo Saúde, Journal Year: 2023, Volume and Issue: 23(5), P. e12852 - e12852

Published: May 11, 2023

Objetivo: Analisar as características da Síndrome de Cushing (SC). Revisão bibliográfica: A SC é ocasionada pela exposição prolongada a altos níveis circulantes cortisol. maioria dos casos mediada exogenamente, através administração glicocorticóides. endógena muito mais rara e apresenta incidência anual 3 por 1.000.000 indivíduos. ocorre mecanismos dependentes ou independentes do hormônio adrenocorticotrofina (ACTH). As comuns incluem depósito gordura centrípeta, estrias abdominais, pletora facial, atrofia muscular, perda densidade óssea, imunossupressão complicações cardiovasculares. Considerações finais: constitui um grave problema saúde com musculoesqueléticas, cardiovasculares neuropsiquiátricas. Seu diagnóstico feito suspeição clínica testes triagem: teste supressão 1 mg dexametasona, cortisol salivar noturno alto urinário livre. terapêutica escolha para ressecção meio cirúrgico lesão primária que levou ao excesso Além disso, opções farmacológicas podem ser utilizadas em nos quais há contraindicação cirúrgica forma adjuvante método operatório.

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Hydrosaline Alterations in Cushing Disease

Endocrinology, Journal Year: 2023, Volume and Issue: unknown, P. 473 - 509

Published: Jan. 1, 2023

Language: Английский

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Targeting Pharmacological and Nanotechnology Based Therapeutics for Management of Hirsutism: A Comprehensive State-of-the-Art

Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 30(1), P. 54 - 69

Published: Dec. 13, 2023

Hirsutism is characterized by the excessive growth of coarse hair in women, resembling typical pattern seen men. It affects between 5 to 10 % females reproductive age. Excessive often leads significant mental and emotional anguish. result an overabundance androgens being secreted ovaries or adrenal glands. This article offers a comprehensive review numerous causes that might provoke hirsutism which includes polycystic ovarian syndrome, Cushing idiopathic hirsutism, insulin resistance, congenital hyperplasia, tumors, menopause, use certain drugs. Polycystic ovary syndrome tumors are frequent underlying factors hyperandrogenism, subsequently results development Hirsutism. Mechanical cosmetic removal methods viable options for managing hirsutism. study examines pharmacological therapies have proven essential enhancing quality life patients. These treatments include oral contraceptives, antiandrogen therapy like spironolactone, cyproterone acetate, flutamide, finasteride, specific insulin-lowering medicines, gonadotrophin-releasing hormone agonists, topical treatment such eflornithine hydrochloride cream (13.9% w/w cream). also explored significance nanotechnology-based nanostructured lipid carriers, solid nanoparticles, liposomes, cerosomes, nanogel effectiveness medications used treat A update has been made latest information on clinical studies patents linked

Language: Английский

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Challenges in the postsurgical recovery of cushing syndrome: glucocorticoid withdrawal syndrome

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: April 12, 2024

Glucocorticoid withdrawal syndrome is a challenging clinical phenomenon that can complicate the postsurgical recovery of Cushing syndrome. It characterized by physical tolerance and dependence to supraphysiologic glucocorticoid exposure during active followed abrupt decline in cortisol levels after surgical treatment. The symptoms often overlap with those postoperative adrenal insufficiency be difficult for patients cope clinicians treat. This mini review will discuss characteristics, pathophysiology, management while highlighting recent data field.

Language: Английский

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Cushing’s syndrome and COVID-19

Pituitary, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Language: Английский

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