Succinate metabolism and its regulation of host-microbe interactions

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: March 22, 2023

Succinate is a circulating metabolite, and the relationship between abnormal changes in physiological concentration of succinate inflammatory diseases caused by overreaction certain immune cells has become research focus. Recent investigations have shown that produced gut microbiota potential to regulate host homeostasis treat such as inflammation. Gut microbes are important for maintaining intestinal homeostasis. Microbial metabolites serve nutrients energy metabolism, act signal molecules stimulate cell organ function affect structural balance symbiotic microorganisms. This review focuses on metabolite both its involvement regulating – tissue axis activating mucosal cells, including macrophages, dendritic epithelial cells. We also examined role mediator crosstalk explores feasible ways moderate levels provides new insights into target microbial therapeutics humans.

Language: Английский

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Gut microbiota in overweight and obesity: crosstalk with adipose tissue

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2023, Volume and Issue: 21(3), P. 164 - 183

Published: Dec. 8, 2023

Language: Английский

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The Implication of Short-Chain Fatty Acids in Obesity and Diabetes

Microbiology Insights, Journal Year: 2023, Volume and Issue: 16

Published: Jan. 1, 2023

Evidence indicates that short-chain fatty acids (SCFAs) generated from the gut microbiota play crucial roles in host metabolism. They contribute to metabolic regulation and energy acquisition of by influencing development disorders. This review aims synthesize recent advances literature investigate implication SCFAs modulation obesity diabetes pathologies. For a better understanding relationships between metabolism, we need answer some questions: What is biochemistry SCFAs, how they are microbiota? bacteria producing which routes? How absorbed transported different mechanisms receptors? involved pathologies?

Language: Английский

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Microbial Metabolites and Gut Immunology

Annual Review of Immunology, Journal Year: 2024, Volume and Issue: 42(1), P. 153 - 178

Published: June 28, 2024

The intestine is the largest peripheral lymphoid organ in animals, including humans, and interacts with a vast array of microorganisms called gut microbiota. Comprehending symbiotic relationship between microbiota our immune system essential not only for field immunology but also understanding pathogenesis various systemic diseases, cancer, cardiometabolic disorders, extraintestinal autoimmune conditions. Whereas microbe-derived antigens are crucial activating intestinal system, particularly T B cells, as environmental cues, microbes their metabolites play critical role directing differentiation these cells. Microbial regarded messengers from microbiota, since bacteria have ability to produce unique molecules that humans cannot, many cells express receptors molecules. This review highlights distinct relationships microbial function system.

Language: Английский

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Emerging role of gut microbiota in autoimmune diseases

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 3, 2024

Accumulating studies have indicated that the gut microbiota plays a pivotal role in onset of autoimmune diseases by engaging complex interactions with host. This review aims to provide comprehensive overview existing literatures concerning relationship between and diseases, shedding light on interplay microbiota, host immune system. Furthermore, we aim summarize impacts potential mechanisms underlie primarily focusing systemic lupus erythematosus, rheumatoid arthritis, Sjögren’s syndrome, type 1 diabetes mellitus, ulcerative colitis psoriasis. The present will emphasize clinical significance applications interventions based as innovative adjunctive therapies for diseases.

Language: Английский

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Cellular succinate metabolism and signaling in inflammation: implications for therapeutic intervention

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 11, 2024

Succinate, traditionally viewed as a mere intermediate of the tricarboxylic acid (TCA) cycle, has emerged critical mediator in inflammation. Disruptions within TCA cycle lead to an accumulation succinate mitochondrial matrix. This excess subsequently diffuses into cytosol and is released extracellular space. Elevated cytosolic levels stabilize hypoxia-inducible factor-1α by inhibiting prolyl hydroxylases, which enhances inflammatory responses. Notably, also acts extracellularly signaling molecule engaging receptor 1 on immune cells, thus modulating their pro-inflammatory or anti-inflammatory activities. Alterations have been associated with various disorders, including rheumatoid arthritis, bowel disease, obesity, atherosclerosis. These associations are primarily due exaggerated cell Given its central role inflammation, targeting pathways offers promising therapeutic avenues for these diseases. paper provides extensive review succinate's involvement processes highlights potential targets future research possibilities development.

Language: Английский

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Host-microbe multi-omics and succinotype profiling have prognostic value for future relapse in patients with inflammatory bowel disease

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 15, 2025

Crohn's disease (CD) and ulcerative colitis (UC) are chronic relapsing inflammatory bowel disorders (IBD), the pathogenesis of which is uncertain but includes genetic susceptibility factors, immune-mediated tissue injury environmental influences, most appear to act via gut microbiome. We hypothesized that host-microbe alterations could be used prognostically stratify patients experiencing relapses up four years after endoscopy. therefore examined multiple omics data, including published new datasets, generated from paired inflamed non-inflamed mucosal biopsies 142 with IBD (54 CD; 88 UC) 34 control (non-diseased) biopsies. The relapse-predictive potential 16S rRNA gene transcript amplicons (standing active microbiota) were investigated along host transcriptomics, epigenomics genetics. While standard single-omics analysis not distinguish between who relapsed those remained in remission within colonoscopy, we did find an association number flares a patient's succinotype. Our multi-omics machine learning approach was also able predict relapse when combining features microbiome human host. Therefore multi-omics, rather than single omics, better predicts 4 while succinotype associated higher frequency relapses.

Language: Английский

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Salivary Metabolomics: From Diagnostic Biomarker Discovery to Investigating Biological Function

Metabolites, Journal Year: 2020, Volume and Issue: 10(2), P. 47 - 47

Published: Jan. 26, 2020

Metabolomic profiling of biofluids, e.g., urine, plasma, has generated vast and ever-increasing amounts knowledge over the last few decades. Paradoxically, metabolomic analysis saliva, most readily-available human biofluid, lagged. This review explores history saliva-based metabolomics summarizes current salivary metabolomics. Current applications have largely focused on diagnostic biomarker discovery value literature base is explored. There also a small, albeit promising, concerning use in monitoring athletic performance. Functional roles metabolites remain unexplored. Areas emerging include role oral host–microbiome interactions shaping metabolite profile potential physiology, taste perception. Discussion future research directions describes need to begin acquiring greater function metabolites, direction field gut metabolome. The saliva as an easily obtainable, information-rich fluid that could complement other gastrointestinal fluids exploration metabolome emphasized.

Language: Английский

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Type 2 Diabetes Mellitus Associated with Obesity (Diabesity). The Central Role of Gut Microbiota and Its Translational Applications

Nutrients, Journal Year: 2020, Volume and Issue: 12(9), P. 2749 - 2749

Published: Sept. 9, 2020

Obesity is a condition of rising prevalence worldwide, with important socioeconomic implications, being considered as growing public health concern. Frequently, obesity brings other complications in addition to itself—like Type 2 Diabetes Mellitus (T2DM)—sharing origin, risk factors and pathophysiological mechanisms. In this context, some authors have decided include both conditions unique entity known “diabesity”. fact, understanding diabesity single disease possible maximise the benefits from therapies received these patients. Gut microbiota plays key role individual’s health, their alterations, either its composition or derived products are related wide range metabolic disorders like T2DM obesity. The present work aims collect different changes reported gut patients associated onset, development, establishment disease. Moreover, current research lines modulate potential clinical translation knowledge system will also be reviewed, which may provide support for better management such complex condition.

Language: Английский

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Microbial interaction between the succinate‐utilizing bacteriumPhascolarctobacterium faeciumand the gut commensalBacteroides thetaiotaomicron

MicrobiologyOpen, Journal Year: 2020, Volume and Issue: 9(10)

Published: Aug. 28, 2020

A large variety of microbes are present in the human gut, some which considered to interact with each other. Most these interactions involve bacterial metabolites. Phascolarctobacterium faecium hardly uses carbohydrates for growth and instead succinate as a substrate. This study investigated behavior co-culture succinate-specific utilizer P. succinogenic gut commensal Bacteroides thetaiotaomicron. Succinate production by B. thetaiotaomicron supported concomitant propionate via pathway. The produced was completely converted propionate. result comparable monoculture medium supplemented 1% (w/v) succinate. We analyzed transcriptional response (RNA-Seq) between mono- Comparison expression levels genes co-cultured conditions highlighted that putatively involved transportation were notably expressed under conditions. Differential analysis showed presence induced changes pattern, example, vitamin B12 transporters reduced glutamate-dependent acid resistance system-related genes. Also, transcriptome suggested glutamate might be used sources succinyl-CoA, an intermediate revealed survival strategies asaccharolytic bacteria, such spp., gut.

Language: Английский

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