Diabesity and Dietary Interventions: Evaluating the Impact of Mediterranean Diet and Other Types of Diets on Obesity and Type 2 Diabetes Management DOI Open Access
Eleni Pavlidou, Sousana Κ. Papadopoulou,

Aristeidis Fasoulas

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 16(1), P. 34 - 34

Published: Dec. 21, 2023

Background: Diabesity, the intersection of obesity and diabetes, presents a global health crisis with profound implications. Addressing diabesity requires multifaceted strategies, diet playing pivotal role. Over last 15 years, clinical studies have intensified their exploration various dietary approaches in management. This literature review aims to synthesize findings from conducted shedding light on efficacy, mechanisms, nuances different types management special focus Mediterranean (MD). Methods: Thorough research academic databases yielded collection relevant studies. These encompassed range including MD, low-carbohydrate diets, plant-based high-protein low-fat regimens, intermittent fasting. Key findings, methodologies, outcomes were thoroughly extracted analyzed. Results: The years witnessed considerable improvements recognizing role human nutritional habits MD appears be most well-recognized diet, exerting favorable effects against both diabetes. Low-carbohydrate diets found enhance glycemic regulation decrease insulin resistance. Plant-based demonstrated potential benefits weight cardiometabolic health. High-protein, models exhibited positive satiety body decline. Intermittent fasting regimens also exerted metabolic Personalization emerged as crucial factor recommendations. Conclusions: Clinical underscore intricate relationship between above results contribute an increasing evidence, emphasizing need for tailored especially MD. Healthcare providers can utilize this knowledge offer personalized recommendations individuals diabesity, potentially curbing rise these twin epidemics improving well-being affected populations.

Language: Английский

Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota–Immune System Interplay. Implications for Health and Disease DOI Open Access
Cielo García‐Montero, Oscar Fraile‐Martínez, Ana M. Gómez-Lahoz

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(2), P. 699 - 699

Published: Feb. 22, 2021

The most prevalent diseases of our time, non-communicable (NCDs) (including obesity, type 2 diabetes, cardiovascular and some types cancer) are rising worldwide. All them share the condition an “inflammatory disorder”, with impaired immune functions frequently caused or accompanied by alterations in gut microbiota. These multifactorial maladies also have common malnutrition related to physiopathology. In this context, diet is greatest modulator system–microbiota crosstalk, much interest, new challenges, arising area precision nutrition as a way towards treatment prevention. It fact that westernized (WD) partly responsible for increased prevalence NCDs, negatively affecting both microbiota system. Conversely, other nutritional approaches, such Mediterranean (MD), positively influence system microbiota, proposed not only potential tool clinical management different disease conditions, but prevention health promotion globally. Thus, purpose review determine regulatory role components WD MD interplay, order understand, create awareness of, over key components.

Language: Английский

Citations

300
Anti-diabetic drugs and weight loss in patients with type 2 diabetes DOI

Elisa Lazzaroni,

Moufida Ben Nasr, Cristian Loretelli

et al.

Pharmacological Research, Journal Year: 2021, Volume and Issue: 171, P. 105782 - 105782

Published: July 22, 2021

Language: Английский

Citations

124
The Mediterranean Diet: An Update of the Clinical Trials DOI Open Access
Mauro Finicelli, Anna Di Salle, Umberto Galderisi

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(14), P. 2956 - 2956

Published: July 19, 2022

The Mediterranean Diet (MedDiet) is a term used to identify dietary pattern originating from the unique multi-millennial interplay between natural food resources and eating practices of people living in basin. Scientific evidence has described healthy properties MedDiet its beneficial role several pathological conditions. Nevertheless, current socio-economic trends have moved away this lifestyle. Thus, clinical biological supporting benefits needed overcome these limitations. Clinical nutrition research examines effects interventions on or health-related outcomes determined study population. produced by studies useful for guidance public health messaging. We provided an update trials registered database clinicaltrials.gov evaluating specific diseases. Our findings revealed increased number last decade found that most disease-related focused cardiovascular diseases, metabolic cancer. majority MedDiet’s could be primarily related anti-inflammatory anti-oxidant as well effectiveness controlling waist circumference obesity. Moreover, strict long-lasting adherence components (e.g., olive oil polyphenols) seem emerge insights interventional improvements. These present further into how it strengthen overall health.

Language: Английский

Citations

119
Microbiota–gut–brain axis mechanisms in the complex network of bipolar disorders: potential clinical implications and translational opportunities DOI Creative Commons
Miguel Á. Ortega, Miguel Ángel Alvarez-Mon, Cielo García‐Montero

et al.

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(7), P. 2645 - 2673

Published: Jan. 27, 2023

Abstract Bipolar disorders (BD) represent a severe leading disabling mental condition worldwide characterized by episodic and often progressive mood fluctuations with manic depressive stages. The biological mechanisms underlying the pathophysiology of BD remain incompletely understood, but it seems that there is complex picture genetic environmental factors implicated. Nowadays, gut microbiota in spotlight new research related to this kind psychiatric disorder, as can be consistently several pathophysiological events observed BD. In context so-called microbiota–gut–brain (MGB) axis, shown have strong influence on host neuromodulation endocrine functions (i.e., controlling synthesis neurotransmitters like serotonin or mediating activation hypothalamic–pituitary–adrenal axis), well modulation immune responses, critically regulating intestinal, systemic brain inflammation (neuroinflammation). present review aims elucidate derived from MGB axis disruption possible therapeutic approaches mainly focusing network Understanding its bidirectional communication other systems shed light discovery therapies for improving clinical management these patients. Besides, effect drugs currently used patients, together therapeutical targeting ecosystem (dietary patterns, probiotics, prebiotics, novelties) will also contemplated.

Language: Английский

Citations

71
Effects of gut microbiota–derived extracellular vesicles on obesity and diabetes and their potential modulation through diet DOI Creative Commons

Ester Díez-Sainz,

Fermı́n I. Milagro, José Ignacio Riezu‐Boj

et al.

Journal of Physiology and Biochemistry, Journal Year: 2021, Volume and Issue: 78(2), P. 485 - 499

Published: Sept. 2, 2021

Abstract Obesity and diabetes incidence rates are increasing dramatically, reaching pandemic proportions. Therefore, there is an urgent need to unravel the mechanisms underlying their pathophysiology. Of particular interest close interconnection between gut microbiota dysbiosis obesity progression. Hence, manipulation through diet has been postulated as a promising therapeutic target. In this regard, secretion of microbiota–derived extracellular vesicles gaining special attention, standing out key factors that could mediate microbiota-host communication. Extracellular (EVs) derived from probiotic bacteria allow encapsulate wide range bioactive molecules (such as/or including proteins nucleic acids) travel short long distances modulate important biological functions with overall impact on host health. EV-derived specific induce differential physiological responses. For example, high-fat diet–induced increase proteobacterium Pseudomonas panacis –derived EV closely associated progression metabolic dysfunction in mice. contrast, Akkermansia muciniphila linked alleviation Here, we review newest pieces evidence concerning potential role probiotic-derived onset, progression, management, modulation inflammation, metabolism, permeability. addition, discuss certain dietary patterns profile clinical implication habits have diseases shaping EV.

Language: Английский

Citations

66
Data mining approaches for type 2 diabetes mellitus prediction using anthropometric measurements DOI Creative Commons
Maryam Saberi‐Karimian, Amin Mansoori, Maryam Mohammadi Bajgiran

et al.

Journal of Clinical Laboratory Analysis, Journal Year: 2022, Volume and Issue: 37(1)

Published: Dec. 12, 2022

The aim of this study was to evaluate the anthropometric measurements most associated with type 2 diabetes mellitus (T2DM) using machine learning approaches.A prospective designed for a total population 9354 (43% men and 57% women) aged 35-65. Anthropometric include weight, height, demispan, Hip Circumference (HC), Mid-arm (MAC), Waist (WC), Body Roundness Index (BRI), Adiposity (BAI), A Shape (ABSI), Mass (BMI), Waist-to-height Ratio (WHtR), Waist-to-hip (WHR) were completed all participants. association assessed logistic regression (LR) decision tree (DT) analysis. Receiver operating characteristic (ROC) curve performed DT's accuracy, sensitivity, specificity R software.Traditionally, 1461 women 875 T2DM (T2DM group). According LR, in males, WC BIA (p-value < 0.001) females, demispan had highest correlation development risk. DT indicated that has crucial effect on risk, followed by HC, BAI.Our results showed both women, important factor predict T2DM.

Language: Английский

Citations

42
A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities DOI Creative Commons
Miguel Á. Ortega, Oscar Fraile‐Martínez, Cielo García‐Montero

et al.

Military Medical Research, Journal Year: 2023, Volume and Issue: 10(1)

Published: June 9, 2023

Abstract Spinal cord injury (SCI) is a devastating and disabling medical condition generally caused by traumatic event (primary injury). This initial trauma accompanied set of biological mechanisms directed to ameliorate neural damage but also exacerbate (secondary The alterations that occur in the spinal have not only local systemic consequences virtually all organs tissues body incur important changes after SCI, explaining progression detrimental related this condition. Psychoneuroimmunoendocrinology (PNIE) growing area research aiming integrate explore interactions among different systems compose human organism, considering mind as whole. consequent neurological disruption trigger immune, endocrine, multisystem dysfunction, which turn affect patient’s psyche well-being. In present review, we will most SCI from PNIE perspective, defining occurring each system how these are interconnected. Finally, potential clinical approaches derived knowledge be collectively presented with aim develop integrative therapies maximize management patients.

Language: Английский

Citations

26
Metabolic Syndrome: A Narrative Review from the Oxidative Stress to the Management of Related Diseases DOI Creative Commons

G. Martemucci,

Giuseppe Fracchiolla, Marilena Muraglia

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(12), P. 2091 - 2091

Published: Dec. 8, 2023

Metabolic syndrome (MS) is a growing disorder affecting thousands of people worldwide, especially in industrialised countries, increasing mortality. Oxidative stress, hyperglycaemia, insulin resistance, inflammation, dysbiosis, abdominal obesity, atherogenic dyslipidaemia and hypertension are important factors linked to MS clusters different pathologies, such as diabesity, cardiovascular diseases neurological disorders. All biochemical changes observed MS, dysregulation the glucose lipid metabolism, immune response, endothelial cell function intestinal microbiota, promote pathological bridges between metabolic syndrome, diabesity neurodegenerative This review aims summarise syndrome's involvement highlight link diseases. A better understanding could novel strategic approach reduce comorbidities.

Language: Английский

Citations

23
Parabens exposure and its impact on diabesity: a review DOI
Ana Ramalho, Abel Vale, Félix Carvalho

et al.

Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 154125 - 154125

Published: March 1, 2025

Language: Английский

Citations

1
Dysbiosis is one of the risk factor for stroke and cognitive impairment and potential target for treatment DOI
Magdalena Koszewicz, Joanna Jaroch, Anna Brzecka

et al.

Pharmacological Research, Journal Year: 2020, Volume and Issue: 164, P. 105277 - 105277

Published: Nov. 7, 2020

Language: Английский

Citations

59