Advanced Science,
Journal Year:
2022,
Volume and Issue:
10(4)
Published: Dec. 11, 2022
Mitochondria
are
the
powerhouse
of
eukaryotic
cells,
which
regulate
cell
metabolism
and
differentiation.
Recently,
mitochondrial
transfer
between
cells
has
been
shown
to
direct
recipient
fate.
However,
it
is
unclear
whether
mitochondria
can
translocate
stem
this
alters
Here,
mesenchymal
(MSC)
regulation
examined
by
macrophages
in
bone
marrow
environment.
It
found
that
promote
osteogenic
differentiation
MSCs
delivering
MSCs.
under
osteoporotic
conditions,
with
altered
phenotypes,
metabolic
statuses
release
oxidatively
damaged
mitochondria.
Increased
M1-like
triggers
a
reactive
oxygen
species
burst,
leads
remodeling.
showed
abnormal
caused
succinate
accumulation,
key
factor
These
results
reveal
from
allows
crosstalk
homeostasis.
This
mechanism
identifies
potential
target
for
treatment
osteoporosis.
Journal of Physiology and Biochemistry,
Journal Year:
2021,
Volume and Issue:
78(2), P. 485 - 499
Published: Sept. 2, 2021
Abstract
Obesity
and
diabetes
incidence
rates
are
increasing
dramatically,
reaching
pandemic
proportions.
Therefore,
there
is
an
urgent
need
to
unravel
the
mechanisms
underlying
their
pathophysiology.
Of
particular
interest
close
interconnection
between
gut
microbiota
dysbiosis
obesity
progression.
Hence,
manipulation
through
diet
has
been
postulated
as
a
promising
therapeutic
target.
In
this
regard,
secretion
of
microbiota–derived
extracellular
vesicles
gaining
special
attention,
standing
out
key
factors
that
could
mediate
microbiota-host
communication.
Extracellular
(EVs)
derived
from
probiotic
bacteria
allow
encapsulate
wide
range
bioactive
molecules
(such
as/or
including
proteins
nucleic
acids)
travel
short
long
distances
modulate
important
biological
functions
with
overall
impact
on
host
health.
EV-derived
specific
induce
differential
physiological
responses.
For
example,
high-fat
diet–induced
increase
proteobacterium
Pseudomonas
panacis
–derived
EV
closely
associated
progression
metabolic
dysfunction
in
mice.
contrast,
Akkermansia
muciniphila
linked
alleviation
Here,
we
review
newest
pieces
evidence
concerning
potential
role
probiotic-derived
onset,
progression,
management,
modulation
inflammation,
metabolism,
permeability.
addition,
discuss
certain
dietary
patterns
profile
clinical
implication
habits
have
diseases
shaping
EV.
Microbiology Spectrum,
Journal Year:
2022,
Volume and Issue:
10(4)
Published: June 29, 2022
Several
studies
showed
associations
between
gut
dysbiosis
and
CRC.
Yet,
the
results
are
not
conclusive
due
to
cohort-specific
that
influenced
by
genomic,
dietary,
environmental
stimuli
associated
reproducibility
issues
with
various
analysis
approaches.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
10(4)
Published: Dec. 11, 2022
Mitochondria
are
the
powerhouse
of
eukaryotic
cells,
which
regulate
cell
metabolism
and
differentiation.
Recently,
mitochondrial
transfer
between
cells
has
been
shown
to
direct
recipient
fate.
However,
it
is
unclear
whether
mitochondria
can
translocate
stem
this
alters
Here,
mesenchymal
(MSC)
regulation
examined
by
macrophages
in
bone
marrow
environment.
It
found
that
promote
osteogenic
differentiation
MSCs
delivering
MSCs.
under
osteoporotic
conditions,
with
altered
phenotypes,
metabolic
statuses
release
oxidatively
damaged
mitochondria.
Increased
M1-like
triggers
a
reactive
oxygen
species
burst,
leads
remodeling.
showed
abnormal
caused
succinate
accumulation,
key
factor
These
results
reveal
from
allows
crosstalk
homeostasis.
This
mechanism
identifies
potential
target
for
treatment
osteoporosis.
