Neuroendocrinological factors in binge eating disorder: A narrative review

Psychoneuroendocrinology, Journal Year: 2023, Volume and Issue: 150, P. 106030 - 106030

Published: Jan. 28, 2023

Neuroendocrine mechanisms play a key role in the regulation of eating behavior. In individuals with binge disorder (BED), alterations these signaling hunger and satiety have been observed. It has investigated that may underlie development maintenance compulsive overeating BED. The present narrative review examined current literature related to neurobiological processes involved feeding dysregulation BED aim updating most relevant aspects special attention neuroendocrine signaling. Studies shown both central peripheral endocrine dysfunctions hormones participating homeostatic hedonic pathways Most studies especially focused on orexigenic signals, pointing out existence hyperactivated mechanism promoting hunger. Fewer explored anorexigenic pathways, but findings so far seem suggest an abnormal threshold. Despite this, date, it is unable identify whether are typical pathophysiology or obesogenic pattern due included patients obesity. identification endophenotypes provide new approach aberrant behavior, favoring implementation biological therapeutic targets.

Language: Английский

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Stress modulates BNST connectivity during food cue and taste processing: a 7T dynamic causal modelling study

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Across species, stress drives alterations in feeding behaviour, including heightened food-seeking and the overconsumption of palatable foods. The bed nucleus stria terminalis (BNST) acts as a neural hub linking reward circuits. However, its role human food cue taste processing under remains unclear. Here, using 7-Tesla fMRI, dynamic causal modelling, in-scanner delivery, we demonstrate that beverage cues receipt modulate effective connectivity BNST stress. Forty-eight participants were presented neutral before receiving corresponding beverages low- high-stress conditions. We found inhibits to accumbens, orbitofrontal cortex, anterior insula. Moreover, high has an inhibitory influence on from insula BNST, strength which predicts participant sensitivity. These findings provide first evidence humans modulates connectivity, leading inhibition cortico-striatal circuitry.

Language: Английский

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Hippocampus, amygdala, and insula activation in response to romantic relationship dissolution stimuli: A case-case-control fMRI study on emerging adult students

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 356, P. 604 - 615

Published: April 16, 2024

Romantic relationship dissolutions (RRDs) are associated with posttraumatic stress symptoms (PTSS). Functional magnetic resonance imaging in RRD studies indicate overlapping neural activation similar to disorder. These combine real and hypothetical rejection, lack contextual information control and/or comparison groups exposed non-RRD or DSM-5 defined traumatic events.

Language: Английский

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The influence of stress on the neural underpinnings of disinhibited eating: a systematic review and future directions for research

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2023, Volume and Issue: 24(4), P. 713 - 734

Published: June 13, 2023

Abstract Disinhibited eating involves overconsumption and loss of control over food intake, underpins many health conditions, including obesity binge-eating related disorders. Stress has been implicated in the development maintenance disinhibited behaviours, but mechanisms underlying this relationship are unclear. In systematic review, we examined how impact stress on neurobiological substrates food-related reward sensitivity, interoception cognitive explains its role behaviours. We synthesised findings functional magnetic resonance imaging studies acute and/or chronic exposures participants with eating. A search existing literature conducted alignment PRISMA guidelines identified seven investigating neural impacts people Five used food-cue reactivity tasks, one study a social evaluation task, an instrumental learning task to probe reward, circuitry. Acute was associated deactivation regions prefrontal cortex hippocampus. However, there were mixed regarding differences reward-related using response negative evaluation. contrast, both when viewing palatable food-cues. Given small number publications notable heterogeneity designs, propose several recommendations strengthen future research emerging field.

Language: Английский

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Smaller subcortical volume relates to greater weight gain in girls with initially healthy weight

Obesity, Journal Year: 2024, Volume and Issue: 32(7), P. 1389 - 1400

Published: May 6, 2024

Among 3614 youth who were 9 to 12 years old and initially did not have overweight or obesity (12% [n = 385] developed obesity), we examined the natural progression of weight gain brain structure development during a 2-year period with high risk for (e.g., pre- early adolescence) determine following: 1) whether variation in maturational trajectories regions contributes gain; and/or 2) altered development.

Language: Английский

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Effects of Fructose and Palmitic Acid on Gene Expression in Drosophila melanogaster Larvae: Implications for Neurodegenerative Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10279 - 10279

Published: June 17, 2023

One of the largest health problems worldwide is development chronic noncommunicable diseases due to consumption hypercaloric diets. Among most common alterations are cardiovascular diseases, and a high correlation between overnutrition neurodegenerative has also been found. The urgency in study specific damage tissues such as brain intestine led us use Drosophila melanogaster metabolic effects caused by fructose palmitic acid tissues. Thus, third instar larvae (96 ± 4 h) wild Canton-S strain D. were used perform transcriptomic profiling midgut test for potential diet supplemented with acid. Our data infer that this can alter biosynthesis proteins at mRNA level participate synthesis amino acids, well fundamental enzymes dopaminergic GABAergic systems brain. These demonstrated flies may help explain various reported human associated humans. studies will not only better understand mechanisms which these alimentary products related neuronal but contribute prevention conditions.

Language: Английский

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Dynamic fronto‐amygdalar interactions underlying emotion‐regulation deficits in women at higher weight

Obesity, Journal Year: 2023, Volume and Issue: 31(9), P. 2283 - 2293

Published: Aug. 6, 2023

Abstract Objective The regulation of negative emotions entails the modulation subcortical regions, such as amygdala, by prefrontal regions. There is preliminary evidence suggesting that individuals at higher weight may present with hypoactivity in regulatory systems during emotional regulation, although directionality these pathways has not been tested. In this study, we compared fronto‐amygdalar effective connectivity cognitive reappraisal a function BMI 48 adult women obesity and 54 control participants. Methods Dynamic causal modeling parametric empirical Bayes were used to map between dorsomedial cortex, orbitofrontal dorsolateral amygdala. Results Difficulty Emotion Regulation Scale scores group participants ( p < 0.001). A top‐down cortical model best explained our functional magnetic resonance imaging data (posterior probability = 86%). Participants less inhibiting activity amygdala via cortex those lower BMI. contrast, increased excitatory cortex‐to‐amygdalar was found Conclusions These findings support framework involving alterations contributing difficulties regulating affect weight.

Language: Английский

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Smaller Subcortical Volume of the Accumbens and Caudate Precede Weight Gain in Youth with High Financial Adversity: Findings from the Abcd Study

Published: Jan. 1, 2024

Background: Financial adversity has been associated with altered subcortical neurodevelopment and obesity risk. However, no studies have examined these relationships in tandem. Food intake is controlled by the subcortex, so we whether financial moderated bi-directional between body mass index (BMI) early adolescence (9-to-12-years-old). Methods: Data were gathered from ABCD Study (nT0=3,606 [9/10-years-old, 100% healthy weight, 50.8% male; 71.4% White, 15.6% Latino, 869 youth adversity]; nT2=2,395 [11/12-years-old, 11.2% overweight/obese]; siblings). Population-level effects of Adversity*Subcortical Volume (8 bilateral regions)*Time on BMI mixed models, while individual differences temporal precedence cross-domain couples a Multiple Indicator Bivariate Latent Change Score Model (BLCS).Results: By 11/12-years-old, higher exhibited stronger negative relationship volume accumbens, caudate, right putamen, alterations predated weight gain.Conclusions: Our findings suggest that may alter development regions reward processing food control, potentially contribute to greater trajectories. elucidating mechanisms within natural progression gain, highlight potential neuro-socioeconomic risk factor for development.

Language: Английский

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Neurofunctional and microstructural features of the brain in patients with nutritional obesity according to special magnetic resonance imaging techniques (literature review)

Medical Visualization, Journal Year: 2024, Volume and Issue: 28(3), P. 53 - 64

Published: July 26, 2024

Background . Obesity is a chronic disease characterized by excessive accumulation of adipose tissue in the body, manifested an increase body weight 20 percent or more average values. becoming increasingly significant public health problem. Assessment functional pathology brain provides information about pathogenetic changes leading to metabolic disorders. Modern methods neuroimaging make it possible obtain initial according data intracerebral connectivity - between its individual structures. Objective The study modern literature on disorders patients with obesity, including those eating Materials and A systematic review studies published foreign domestic has been carried out. Articles were searched using PubMed database Elibrary. Results. problem microstructural obesity covered sufficient detail Western English-language literature. Nevertheless, must be stated that at moment there are practically no articles subject under scientific publications. However, should noted rare aspect neural network connectivity, concomitant somatic pathology, for example, type II diabetes, other endocrine system. There relatively few where correlations would made age gender patients, mental disorders, which emphasizes relevance issue. At subsequent stages joint development endocrinology, psychiatry radiation diagnostics, use MRI techniques will help choice target structures stereotaxic correction described pathology. clinical application reveal pathogenesis various types neurofunctional levels further prediction analysis disease, while inconsistency currently obtained results alimentary terms based fMRI, absence special substantiate need continue research this direction

Language: Английский

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Foreword to the special issue on the neuroscience of obesity and related disorders

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2022, Volume and Issue: 23(4), P. 679 - 681

Published: June 13, 2022

Language: Английский

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