The Role of Nutrition on Thyroid Function

Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2496 - 2496

Published: July 31, 2024

Thyroid function is closely linked to nutrition through the diet–gut–thyroid axis. This narrative review highlights influence of nutritional components and micronutrients on thyroid development function, as well gut microbiota. Micronutrients such iodine, selenium, iron, zinc, copper, magnesium, vitamin A, B12 hormone synthesis regulation throughout life. Dietary changes can alter microbiota, leading not just dysbiosis micronutrient deficiency but also in immunological regulation, nutrient absorption, epigenetic changes. Nutritional imbalance lead dysfunction and/or disorders, hypothyroidism hyperthyroidism, possibly contribute autoimmune diseases cancer, yet controversial issues. Understanding these relationships important rationalize a balanced diet rich essential for maintaining health preventing thyroid-related diseases. The synthetic comprehensive overview current knowledge shows importance microbiota uncovers potential gaps that require further investigation.

Language: Английский

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Changes in Hormonal Profile and Body Mass Index in Women with Polycystic Ovary Syndrome After Probiotic Intake: A 12-Week Placebo-Controlled and Randomized Clinical Study

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 405 - 405

Published: Jan. 23, 2025

Introduction: The beneficial effect of probiotics on the improvement carbohydrate and lipid metabolism, as well body mass index (BMI), has been demonstrated in various patient groups. We aimed to investigate a multi-strain probiotic hormonal balance women with PCOS. Ethical approval was obtained from Bioethical Committee. Methods: study designed 12-week, randomized, double-blind, placebo-controlled clinical study. SanProbi® Barrier capsules, which contain unique composition nine bacteria strains (Lactobacillus Biffidobacterium), were used mean age participants 28.42 ± 5.62 years. A total 50 PCOS, diagnosed based Rotterdam ESHRE criteria, included Among them, 25 randomized placebo group, group. Results: comparison changes individual hormone levels between groups confirmed statistically significant differences for TSH, androstenedione, SHBG, BMI. In case LH, statistical significance difference delta change group use one-tailed test. Conclusions: Probiotic supplementation may serve an alternative supporting treatment, especially phenotype high FAI index. therapy is also effective reducing BMI overweight PCOS

Language: Английский

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Causal effect of gut microbiota of Defluviitaleaceae on the clinical pathway of “Influenza–Subacute Thyroiditis–Hypothyroidism”

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 26, 2024

Introduction Hypothyroidism has been found to be influenced by gut microbiota. However, it remains unclear which a taxon of microbiota plays key role in this function. Identifying the bacteria affects hypothyroidism and through what mechanism will helpful for prevention specific clinical pathways. Materials methods In Study A, 35 families 130 genera are used as exposures, with outcome. The causal effect on is estimated two-sample Mendelian randomization. Combining results two taxonomical levels, taxa selected, B investigated their association multiple generally admitted causes more upstream factors. For validating revealing potential mechanism, enrichment analyses related genes interacting transcription factors were performed. Results Defluviitaleaceae (OR: 0.043, 95% CI: 0.005–0.363, P = 0.018)/ Defluviitaleaceae_UCG_011 0.385, 0.172–0.865, 0.021) significantly causally associated at both levels. B, family genus show decreased thyroiditis (Family: OR: 0.174, 0.046–0.653, 0.029; Genus: 0.139, 0.029–0.664, 0.043), subacute 0.028, 0.004–0.213, 0.007; 0.018, 0.002–0.194, 0.013), influenza 0.818, 0.676–0.989, 0.038; 0.792, 0.644–0.974, 0.027), increased anti-influenza H3N2 IgG levels 1.934, 1.123–3.332, 0.017; 1.675, 0.953–2.943, 0.073). analysis consistent findings suggested possible mechanisms. Conclusion displays probability inhibiting pathway “Influenza–Subacute Thyroiditis–Hypothyroidism” acts probiotics prevent influenza, thyroiditis, hypothyroidism.

Language: Английский

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Effects of Dietary Habits on Markers of Oxidative Stress in Subjects with Hashimoto’s Thyroiditis: Comparison Between the Mediterranean Diet and a Gluten-Free Diet

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 363 - 363

Published: Jan. 20, 2025

Background: The Mediterranean diet (MedD) exerts anti-inflammatory and anti-oxidant effects that are beneficial in autoimmune thyroid diseases (ATD). Recently, a gluten-free (GFD) has been proposed for non-celiac patients with Hashimoto’s thyroiditis (HT), but its usefulness is under debate. present pilot study evaluates the of these two dietary regimes, focus on redox homeostasis, HT. Patients Methods: 45 euthyroid HT (30 F; median age 42 years) were randomly assigned to different regimes: MedD (n = 15), GFD 15) free (FD, n 15). Thyroid function tests, autoantibodies, oxidative stress markers (Advanced glycation end products, AGEs; glutathione peroxidase (GPx), thioredoxin reductase (TRxR), total plasma antioxidant activity (TEAA) measured at baseline after 12 weeks. Results: In group, significantly lower values AGEs higher GPX, TRX TEAA action detected (p < 0.05) weeks compared baseline, FD groups, which parameters did not change > 0.05). No significant differences serum levels TSH, FT4, Ab-Tg, Ab-TPO found any group. Conclusions: This confirms protective effect against stress, while does influence and/or autoimmunity/function parameters.

Language: Английский

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Nutrition, intestinal microbiota, and thyroid autoimmune pathology

Russian Journal of Preventive Medicine, Journal Year: 2025, Volume and Issue: 28(1), P. 102 - 102

Published: Jan. 1, 2025

Language: Английский

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Modulation of Intestinal Flora: a Novel Immunotherapeutic Approach for Enhancing Thyroid Cancer Treatment

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Language: Английский

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Lack of genotoxicity and subchronic toxicity in safety assessment studies of Akkermansia muciniphila formulation

Toxicology Reports, Journal Year: 2024, Volume and Issue: 13, P. 101790 - 101790

Published: Oct. 28, 2024

Language: Английский

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Altitude shapes gut microbiome composition accounting for diet, thyroid hormone levels, and host genetics in a subterranean blind mole rat

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 1, 2024

The animal gut microbiome acts as a crucial link between the host and its environment, playing vital role in digestion, metabolism, physiology, fitness. Using 16S rRNA metabarcoding, we investigated effect of altitude on composition Anatolian Blind Mole Rats (

Language: Английский

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