Biogenic green metal nano systems as efficient anti-cancer agents

Environmental Research, Journal Year: 2023, Volume and Issue: 229, P. 115933 - 115933

Published: April 19, 2023

Language: Английский

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A review on applications of coumarin and its derivatives in preparation of photo-responsive polymers

European Polymer Journal, Journal Year: 2023, Volume and Issue: 198, P. 112430 - 112430

Published: Sept. 18, 2023

Language: Английский

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Recent Trends in the Synthesis and Bioactivity of Coumarin, Coumarin–Chalcone, and Coumarin–Triazole Molecular Hybrids

Molecules, Journal Year: 2024, Volume and Issue: 29(5), P. 1026 - 1026

Published: Feb. 27, 2024

Molecular hybridization represents a new approach in drug discovery which specific chromophores are strategically combined to create novel drugs with enhanced therapeutic effects. This innovative strategy leverages the strengths of individual address complex biological challenges, synergize beneficial properties, optimize pharmacokinetics, and overcome limitations associated single-agent therapies. Coumarins documented possess several bioactivities have therefore been targeted for combination other active moieties molecular hybrids. review summarizes recent (2013–2023) trends synthesis coumarins, as well coumarin–chalcone coumarin–triazole To cover wide aspects this area, we included differently substituted chalcones, 1,2,3– 1,2,4–triazoles considered point fusion/attachment coumarin show diversity these The reported syntheses mainly relied on well-established chemistry without need strict reaction conditions usually produced high yields. Additionally, discussed compounds, including antioxidative, antimicrobial, anticancer, antidiabetic, anti-cholinesterase activities commented their IC50 where possible. Promising bioactivity results obtained so far. It is noted that mechanistic studies infrequently found published work, was also mentioned give reader better understanding. aims provide valuable information enable further developments field.

Language: Английский

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Recent advances on biologically active coumarin-based hybrid compounds

Medicinal Chemistry Research, Journal Year: 2023, Volume and Issue: 32(4), P. 617 - 642

Published: Feb. 9, 2023

Language: Английский

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Green Biosynthesis of Zinc Oxide Nanoparticles Using Pluchea indica Leaf Extract: Antimicrobial and Photocatalytic Activities

Molecules, Journal Year: 2023, Volume and Issue: 28(12), P. 4679 - 4679

Published: June 9, 2023

Nanotechnology is playing a critical role in several essential technologies with nanoscale structures (nanoparticles) areas of the environment and biomedicine. In this work, leaf extract Pluchea indica was utilized to biosynthesize zinc oxide nanoparticles (ZnONPs) for first time evaluated antimicrobial photocatalytic activities. Different experimental methods were used characterize biosynthesized ZnONPs. The ZnONPs showed maximum Ultraviolet-visible spectroscopy (UV-vis) absorbance at wavelength 360 nm. X-Ray diffraction (XRD) pattern exhibits seven strong reflection peaks, average particle size 21.9 Fourier-transform infrared (FT-IR) spectrum analysis reveals presence functional groups that help biofabrication. existence Zn O confirmed by Energy-dispersive X-ray (EDX) morphology SEM images. Antimicrobial studies have efficacy against Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Bacillus subtilis, Staphylococcus aureus, Candida albicans Cryptococcus neoformans where inhibition zones concentration 1000 µg/mL 21.83 ± 0.76, 13.0 1.1, 14.9 0.85, 24.26 17.0 1.0, 20.67 0.57 19.0 1.0 mm respectively. Under both dark sunlight irradiation, activity towards degradation thiazine dye (methylene blue-MB). Approximately 95% MB broken down pH 8 after 150 min exposure. aforementioned results, therefore, suggest synthesized implementing environmentally friendly techniques can be employed variety environmental biomedical applications.

Language: Английский

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Coumarins: Chemical Synthesis, Properties and Applications

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, Journal Year: 2025, Volume and Issue: 13(1), P. 131 - 170

Published: Jan. 30, 2025

Coumarins are compounds characterized by a benzopyrone structure resulting from the condensation of pyrone and benzene ring. They commonly found as secondary metabolites in various plants, microorganisms, sponges. These play crucial role defence mechanisms, extensive research has revealed numerous biological activities associated with these compounds. Coumarin its derivatives show significant potential candidates for new drugs due to their exceptional biocompatibility wide range activities, including antimicrobial, anticancer, antimitotic, antioxidant, anti-inflammatory, anticoagulant properties. Beyond medicinal applications, simple versatile scaffold structures coumarins have use fields such food production, agriculture, cosmetics, textiles. This review covers classification coumarin derivatives, well chemical synthesis methods. Furthermore, it delves into properties, diverse application areas coumarins.

Language: Английский

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Synthesis and antimicrobial activity of new series of thiazoles, pyridines and pyrazoles based on coumarin moiety

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: June 19, 2023

Abstract Microbial infections are currently a widespread disease in hospitals and community health centres major cause of death worldwide. In pursuit searching new antimicrobial agents, coumarin linked to thiazoles, pyridines pyrazoles have been developed evaluated for their properties against two Gram + bacteria, − bacteria as well fungi. Some the prepared coumarins displayed high moderate activity tested microorganisms with respect reference drugs. However, compound 3 exhibited effect equal drug Ciprofloxacin baceria Enterobacter cloacae . Compound 12 was found be most potent Bacillus pumilis MIC 7.69 (µmol/ml). Compounds , 4 showed remarkable Streptococcus faecalis 14.34, 3.67 15.36 (µmol/ml), respectively. Regarding Escherichia coli compounds recorded values (4.73–45.46 µmol/ml). Moreover, case E. 9 value 22.76

Language: Английский

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Synthesis, Structural and Optical Properties of Co Doped Sm₂O₃ Nanostructures

Advanced materials research, Journal Year: 2022, Volume and Issue: 1173, P. 59 - 69

Published: Aug. 25, 2022

In the present investigation Co doped Sm 2 O 3 nanostructures (NS) with different concentrations (1%, 3% and 8%) synthesized by thermal decomposition surface reduction methods using sodium hydroxide as precipitating agent. Flake-like shaped semiconductor crystal features, morphology, optical absorptivity, chemical composition determined XRD (X-ray diffraction), SEM (scanning electron microscopy) UV-Visible. morphology of NS observed in analysis having grain size varies between 80 96 nm. pattern depicted mixed phase cubic structure crystallite lying 36.8 29.9 Red shift absorptivity was spectrum, spectral from ultraviolet to visible region band gap (Eg) value decreases 4.33 2.01 eV. Upon excitation radiation (excitation = 300 nm), showed red emission all dopant maximal intensity appeared at 485.5 nm for 8% concentration. The finds prominent utility field optoelectronics photoelectronic applications.

Language: Английский

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Synthesis of Cs-Ag/Fe2O3 Nanoparticles Using Vitis labrusca Rachis Extract as Green Hybrid Nanocatalyst for the Reduction of Arylnitro Compounds

Topics in Catalysis, Journal Year: 2022, Volume and Issue: unknown

Published: March 18, 2022

Language: Английский

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Zinc oxide nanoparticles: biogenesis and applications against phytopathogens

Journal of Plant Pathology, Journal Year: 2023, Volume and Issue: 106(1), P. 45 - 65

Published: Oct. 17, 2023

Language: Английский

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