Research Square (Research Square),
Journal Year:
2022,
Volume and Issue:
unknown
Published: Sept. 14, 2022
Abstract
Objective:
In
this
study,
the
possible
protective
effect
of
7,8-Dihydroxyflavone
(7,8-DHF),
a
brain-derived
neurotrophic
factor
(BDNF)
mimetic
and
anti-oxidant
flavonoid,
in
renal
damage
caused
by
cafeteria
diet-induced
obesity
was
investigated.
Method:
4-5
week
old
C57BL/6
male
mice
were
used
subjects
divided
into
4
groups
as
Control,
CD
(cafeteria
diet),
CD+Vehicle
CD+7,8-DHF
(n=9-11).
Control
group
fed
with
chow
diet
for
16
weeks
other
diet.
last
28
days
feeding
period,
7,8-DHF
treatment
(5
mg/kg/day,
intraperitoneal)
administered
group,
DMSO
(17%)
carrier
group.
At
end
weeks,
sacrificed
malondialdehyde
(MDA),
reduced
glutathione
(GSH),
nitrite
+
nitrate
(NOx)
collagen
levels,
superoxide
dismutase
(SOD)
catalase
(CAT)
enzyme
activities
measured
kidney
tissues.
Results:
body
weights
all
increased
compared
to
baseline.
Weight
gain
higher
(p<0.001)
control.
The
weight
not
different
from
Compared
gains
lower.
control
had
MDA
level
(p<0.0001),
lower
GSH
less
SOD
(p<0.0001)
CAT
activity,
NOx
levels.
Vehicle
administration
did
affect
these
parameters
results
similar
However,
significant
changes
noted
treatment.
levels
(p<0.001),
activities.
brought
closer
values,
but
fully
return
control,
except
activity.
Renal
deposition
affected
Conclusion:
Oxidative
stress
plays
an
important
role
obesity-induced
damage.
may
be
suppression
obesity,
at
least
inhibiting
oxidative
excessive
nitric
oxide
production.
increasing
prevalence
eating
habits
together
society,
makes
clinically
important.
These
effects
need
investigated
more
details.
Life,
Journal Year:
2025,
Volume and Issue:
15(2), P. 263 - 263
Published: Feb. 9, 2025
Diabetic
retinopathy
(DR),
a
leading
cause
of
vision
impairment
worldwide,
is
characterized
by
progressive
damage
to
the
retina
due
prolonged
hyperglycemia.
Despite
advances
in
treatment,
current
interventions
largely
target
late-stage
vascular
complications,
leaving
underlying
neurodegenerative
processes
insufficiently
addressed.
This
article
explores
crucial
role
neuronal
survival,
axonal
growth,
and
synaptic
plasticity
neuroprotective
potential
Brain-Derived
Neurotrophic
Factor
(BDNF)
as
therapeutic
strategy
for
enhancing
retinal
resilience
DR.
Furthermore,
it
discusses
innovative
delivery
methods
BDNF,
such
gene
therapy
nanocarriers,
which
may
overcome
challenges
achieving
sustained
targeted
levels
retina,
focusing
on
early
intervention
preserve
function
prevent
loss.
Stem Cell Research & Therapy,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Sept. 2, 2022
Abstract
Background
The
therapeutic
potential
of
mesenchymal
stem
cells
(MSCs)-derived
conditioned
media
(CM)
can
be
increased
after
preconditioning
with
various
chemical
agents.
aim
this
study
is
comparative
evaluation
effects
N-CM
and
DFS-CM
which
are
collected
from
normal
(N)
deferoxamine
(DFS)
preconditioned
umbilical
cord-derived
MSCs
on
rat
diabetic
nephropathy
(DN)
model.
Methods
After
incubation
the
in
serum-free
medium
with/without
150
µM
DFS
for
48
h,
contents
were
analyzed
by
enzyme-linked
immunosorbent
assay.
Diabetes
(D)
was
induced
single
dose
55
mg/kg
streptozotocin.
Therapeutic
CMs
evaluated
biochemical,
physical,
histopathological
immunohistochemical
analysis.
Results
concentrations
vascular
endothelial
growth
factor
alpha,
nerve
glial-derived
neurotrophic
increased,
while
one
brain-derived
decreased
comparison
N-CM.
creatinine
clearance
rate
significantly
both
treatment
groups,
improvement
albumin/creatinine
ratio
renal
mass
index
values
only
significant
D
+
group.
Light
electron
microscopic
deteriorations
loss
podocytes-specific
nephrin
Wilms
tumor-1
(WT-1)
expressions
restored
groups.
Tubular
beclin-1
expression
DN
group,
but
it
Terminal
deoxynucleotidyl
transferase
dUTP
nick
end
labeling
(TUNEL)-positive
apoptotic
cell
death
tubules
Conclusions
more
effective
reducing
podocyte
damage
tubular
regulating
autophagic
activity
its
concentrated
secretome
content
than
Graphical
Cells,
Journal Year:
2024,
Volume and Issue:
13(10), P. 880 - 880
Published: May 20, 2024
MicroRNAs
can
interfere
with
protein
function
by
suppressing
their
messenger
RNA
translation
or
the
synthesis
of
its
related
factors.
The
brain-derived
neurotrophic
factor
(BDNF)
is
essential
to
proper
formation
and
nervous
system
seen
be
regulated
many
microRNAs.
However,
understanding
how
microRNAs
influence
BDNF
actions
within
cells
requires
a
wider
comprehension
integrative
regulatory
mechanisms.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(21), P. 11416 - 11416
Published: Oct. 22, 2021
Obesity
is
a
major
global
health
problem
and
associated
with
significant
risk
of
renal
function
decline.
Obesity-related
nephropathy,
as
one
the
complications
obesity,
characterized
by
structural
functional
damage
kidney
represents
important
contributors
to
morbidity
mortality
worldwide.
Despite
increasing
data
linking
hyperlipidemia
lipotoxicity
injury,
apprehension
molecular
mechanisms
leading
development
scarce.
MicroRNAs
(miRNAs)
are
endogenously
produced
small
noncoding
RNA
molecules
an
in
post-transcriptional
regulation
gene
expression.
miRNAs
have
been
demonstrated
be
regulators
vast
array
physiological
pathological
processes
many
organs,
being
them.
In
this
review,
we
present
overview
miRNAs,
focusing
on
their
role
pathogenesis
obesity-associated
pathologies.
We
explain
novel
findings
regarding
miRNA-mediated
signaling
obesity-related
nephropathies
highlight
advantages
future
perspectives
therapeutic
application
diseases.
