Ferroptosis: a new hunter of hepatocellular carcinoma

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: March 13, 2024

Abstract Ferroptosis is an iron ion-dependent, regulatory cell death modality driven by intracellular lipid peroxidation that plays a key role in the development of HCC. Studies have shown various clinical agents (e.g., sorafenib) ferroptosis inducer-like effects and can exert therapeutic modulating different factors pathway. This implies targeting tumor may be very promising strategy for therapy. In this paper, we summarize prerequisites defense systems occurrence targets drug-mediated action HCC, differences connections between other programmed deaths. We aim to theoretical basis, classical inducers research progress HCC cells, clued treatment regulating network. Further investigation specific mechanisms hepatocellular carcinoma interventions at stages will help us deepen our understanding carcinoma, with view providing new more precise preventive as well measures patients.

Language: Английский

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Lipopeptide C₁₇ Fengycin B Exhibits a Novel Antifungal Mechanism by Triggering Metacaspase-Dependent Apoptosis in Fusarium oxysporum

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(14), P. 7943 - 7953

Published: March 26, 2024

Fusarium wilt is a worldwide soil-borne fungal disease caused by oxysporum that causes serious damage to agricultural products. Therefore, preventing and treating fusarium of great significance. In this study, we purified ten single lipopeptide fengycin components from Bacillus subtilis FAJT-4 found C17 B inhibited the growth F. FJAT-31362. We observed early apoptosis hallmarks, including reactive oxygen species accumulation, mitochondrial dysfunction, phosphatidylserine externalization in B-treated cells. Further data showed induces cell metacaspase-dependent manner. Importantly, expression autophagy-related genes TOR signaling pathway was significantly upregulated; simultaneously, accumulation acidic autophagy vacuoles indicated activated during induced B. study provides new insights into antifungal mechanism fengycin.

Language: Английский

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Diversification of Lipopeptide Analogues Drives Versatility in Biological Activities

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Cyclic lipopeptides (CLPs) are potent secondary metabolites with diverse biological functions.

Language: Английский

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Microbial lipopeptides: their pharmaceutical and biotechnological potential, applications, and way forward

World Journal of Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 40(4)

Published: March 15, 2024

Language: Английский

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2-Methylbutyric acid functions as a potential antifungal fumigant by inhibiting Botrytis cinerea and inducing resistance to gray mold in cherry tomatoes

Postharvest Biology and Technology, Journal Year: 2024, Volume and Issue: 222, P. 113343 - 113343

Published: Dec. 3, 2024

Language: Английский

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Fungal membrane determinants affecting sensitivity to antifungal cyclic lipopeptides from Bacillus spp.

Fungal Biology, Journal Year: 2024, Volume and Issue: 128(7), P. 2080 - 2088

Published: Aug. 15, 2024

Bacillus spp. produce numerous antimicrobial metabolites. Among these metabolites, cyclic lipopeptides (CLP) including fengycins, iturins, and surfactins are known to have varying antifungal activity against phytopathogenic fungi. The differential activities of CLP been attributed diverse mechanisms action on fungal membranes. However, the precise biochemical determinants driving their modes not conclusively identified. In this study, three plant pathogenic fungi lipopeptide sensitivities, Alternaria solani, Cladosporium cucumerinum, Fusarium sambucinum, were studied determine how cell membrane lipid compositions may confer sensitivity and/or tolerance fengycin, iturin, surfactin. Results indicated that all correlated with lower ergosterol content elevated phospholipid fatty acid unsaturation. Fungal surfactin was also notably different than fengycin as influenced more by phosphatidylethanolamine amounts, higher levels phosphatidylinositol, less acyl chain length. from study provide insight into composition A. F. C. cucumerinum specific characteristics influencing effectiveness Understanding should enable accurate prediction sensitivity-tolerance outcomes for other species exposed important CLP.

Language: Английский

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Analysis of the Genomic Sequences and Metabolites of Bacillus velezensis YA215

Biochemical Genetics, Journal Year: 2024, Volume and Issue: 62(6), P. 5073 - 5091

Published: Feb. 22, 2024

Language: Английский

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Important role of Bacillus subtilis as a probiotic and vaccine carrier in animal health maintenance

World Journal of Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 40(9)

Published: July 15, 2024

Language: Английский

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Biocontrol of gray spot disease on Polygonatum cyrtonema Hua by Bacillus velezensis GX1

Biological Control, Journal Year: 2025, Volume and Issue: unknown, P. 105704 - 105704

Published: Jan. 1, 2025

Language: Английский

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The Role of Quorum Sensing Effector Coma in Regulating Biofilm Formation and Surfactin Production in Bacillus Subtilis Asag 010

Published: Jan. 1, 2025

Language: Английский

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