Nuclear‐Targeted Nanostrategy Regulates Spatiotemporal Communication for Dual Antitumor Immunity DOI
Ben Wang, Zhichao Hu,

Li‐Jie Chen

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(4)

Published: Nov. 17, 2023

Intercellular communication between tumor cells and immune regulates progression including positive with activation negative escape. An increasing number of methods are employed to suppress the dominant in tumors such as PD-L1/PD-1. However, how effectively improve is still a challenge. In this study, nuclear-targeted photodynamic nanostrategy developed establish spatiotemporal communication, further activating dual antitumor immunity, namely innate adaptative immunity. The mSiO2 -Ion@Ce6-NLS nanoparticles (NPs) designed, whose surface modified by ionic liquid silicon (Ion) nuclear localization signal peptide (NLS: PKKKRKV), their pores loaded photosensitizer hydrogen chloride e6 (Ce6). Ion-modified NPs enhance intratumoral enrichment, NLS-modified exhibit characteristics achieve therapy (nPDT). nPDT facilitate release damaged double-stranded DNA from activate macrophages via stimulator interferon gene signaling induce immunogenic cell death dendritic "eat me" signals, ultimately leading recruitment CD8+ T-cells. This strengthens reshape microenvironment, inducing long-term memory, eventually inhibiting growth recurrence.

Language: Английский

Sympathetic nerve-enteroendocrine L cell communication modulates GLP-1 release, brain glucose utilization, and cognitive function DOI Creative Commons

Wenran Ren,

Jianhui Chen, Wenjing Wang

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(6), P. 972 - 990.e8

Published: Jan. 21, 2024

Language: Английский

Citations

11
Melanin/melanin-like nanoparticles: As a naturally active platform for imaging-guided disease therapy DOI Creative Commons
Jinghua Sun, Yahong Han, Jie Dong

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 23, P. 100894 - 100894

Published: Dec. 1, 2023

The development of biocompatible and efficient nanoplatforms that combine diagnostic therapeutic functions is great importance for precise disease treatment. Melanin, an endogenous biopolymer present in living organisms, has attracted increasing attention as a versatile bioinspired functional platform owing to its unique physicochemical properties (e.g., high biocompatibility, strong chelation metal ions, broadband light absorption, drug binding properties) inherent antioxidant, photoprotective, anti-inflammatory, anti-tumor effects. In this review, the fundamental preparation methods natural melanin melanin-like nanoparticles were outlined. A systematical description recent progress single, dual-, tri-multimodal imaging-guided visual administration treatment osteoarthritis, acute liver injury, kidney lung brain periodontitis, iron overload, etc. Was then given. Finally, it concluded with reasoned discussion current challenges toward clinical translation future striving directions. Therefore, comprehensive review provides insight into status research expected optimize design novel melanin-based platforms further translation.

Language: Английский

Citations

13
面向先进生物医学应用的光声显微成像术（特邀） DOI Open Access

马海钢 Ma Haigang,

吴家辉 Wu Jiahui,

朱亚辉 Zhu Yahui

et al.

Laser & Optoelectronics Progress, Journal Year: 2024, Volume and Issue: 61(6), P. 0618006 - 0618006

Published: Jan. 1, 2024

光声显微成像(PAM)是一种具有无损、多功能、高分辨率等特点的生物医学成像技术,通过检测光声信号进行图像重建可实现高分辨率和高深度的结构和功能成像,在生命科学、基础医学和医疗诊断中发挥着越来越重要的作用。首先概述光声显微技术的发展背景和原理特点,然后对利用光学增强、声学增强、人工智能增强及光学与声学互补的光声显微成像术促进成像性能提升的方法进行论述,最后讨论当前光声显微技术在生物医学研究中的广泛应用,并对未来技术的发展趋势进行展望。

Citations

1
Discriminative non-destructive imaging of flip chips based on photoacoustic remote sensing microscopy with layered elasto-optic models DOI Creative Commons
Jijing Chen, Kaixuan Ding,

Yihan Pi

et al.

Optics Express, Journal Year: 2024, Volume and Issue: 32(13), P. 22700 - 22700

Published: May 21, 2024

Discriminative internal imaging for different chip layers can pinpoint the location of critical defect in flip chips, yet existing methods face challenges in-line to identify defects or structures from sub-surface within silicon substrate and their underlying coating. To address these challenges, we develop verify layered elasto-optic models photoacoustic remote sensing microscopy (PARS) that distinguish multi-layers a single device flip-chip wafer inspection. A finite-difference time-domain algorithm based on transparent source (TS-FDTD) accurately predicts initial slopes PARS signals silicon-metal silicon-air models. The are experimentally validated utilized discriminative non-destructive interdigital electrode chips cracks same region interest. with non-contact fast scanning has potential detection various refractive indices, offering an approach testing (NDT) structures.

Language: Английский

Citations

0
Nuclear‐Targeted Nanostrategy Regulates Spatiotemporal Communication for Dual Antitumor Immunity DOI
Ben Wang, Zhichao Hu,

Li‐Jie Chen

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(4)

Published: Nov. 17, 2023

Intercellular communication between tumor cells and immune regulates progression including positive with activation negative escape. An increasing number of methods are employed to suppress the dominant in tumors such as PD-L1/PD-1. However, how effectively improve is still a challenge. In this study, nuclear-targeted photodynamic nanostrategy developed establish spatiotemporal communication, further activating dual antitumor immunity, namely innate adaptative immunity. The mSiO2 -Ion@Ce6-NLS nanoparticles (NPs) designed, whose surface modified by ionic liquid silicon (Ion) nuclear localization signal peptide (NLS: PKKKRKV), their pores loaded photosensitizer hydrogen chloride e6 (Ce6). Ion-modified NPs enhance intratumoral enrichment, NLS-modified exhibit characteristics achieve therapy (nPDT). nPDT facilitate release damaged double-stranded DNA from activate macrophages via stimulator interferon gene signaling induce immunogenic cell death dendritic "eat me" signals, ultimately leading recruitment CD8+ T-cells. This strengthens reshape microenvironment, inducing long-term memory, eventually inhibiting growth recurrence.

Language: Английский

Citations

1