Environment International,
Journal Year:
2022,
Volume and Issue:
166, P. 107368 - 107368
Published: June 22, 2022
Comparative
studies
of
neonicotinoid
insecticides
(NNIs)
and
NNI-related
substances
(r-NNIs)
in
foodstuffs
indoor
dust
are
rare.
Herein,
we
investigated
the
feature
fragmentations
nine
NNIs
high-energy
collision
dissociation
cells
via
high-resolution
orbitrap
mass
spectrometry
observed
that
can
consistently
generate
several
fragments
(e.g.,
C6H5NCl+,
C4H3NSCl+,
C6H5NF3+).
Consequently,
r-NNIs
were
comprehensively
(targeted,
suspect,
fragment-dependent)
detected
107
foodstuff
49
samples
collected
from
Nanjing
City
(eastern
China).
We
fully
or
tentatively
identified
9
target
5
these
samples.
93.5%
analyzed
samples,
high
concentrations
vegetables
(mean:
409
ng/g
wet
weight
[ww])
fruits
(127
ww).
Regarding
dust,
imidacloprid
acetamiprid
exhibited
extremely
detection
frequencies
contamination
levels,
highest
mean
dormitory
Based
on
NNI
r-NNI
estimated
daily
intake
values
for
Chinese
adults
children
dietary
ingestion
2080–8190
ng/kg
bw/day
378–2680
pg/kg
bw/day,
respectively.
Nature,
Journal Year:
2024,
Volume and Issue:
633(8030), P. 646 - 653
Published: Aug. 14, 2024
Guanidine
is
a
chemically
stable
nitrogen
compound
that
excreted
in
human
urine
and
widely
used
manufacturing
of
plastics,
as
flame
retardant
component
propellants,
well
known
protein
denaturant
biochemistry
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(13), P. 6979 - 6987
Published: March 23, 2024
Potato
virus
Y
(PVY)
is
an
important
plant
that
has
spread
worldwide,
causing
significant
economic
losses.
To
search
for
novel
structures
as
potent
antiviral
agents,
a
series
of
chiral
indole
derivatives
containing
oxazoline
moieties
were
designed
and
synthesized
their
anti-PVY
activities
evaluated.
Biological
activity
tests
demonstrated
many
compounds
exhibited
promising
absolute
configurations
obvious
distinctions
in
bioactivities.
Notably,
compound
(S)-4v
displayed
excellent
curative
protective
efficacy
against
PVY,
with
EC50
values
328.6
256.1
μg/mL,
respectively,
which
superior
to
those
commercial
virucide
ningnanmycin
(NNM,
437.4
397.4
respectively).
The
preliminary
mechanism
was
investigated
determine
the
difference
between
two
enantiomers
4v
compounds.
Molecular
docking
indicated
stronger
binding
affinity
coating
proteins
PVY
(PVY-CP)
(−6.5
kcal/mol)
compared
(R)-4v
(−6.2
kcal/mol).
Additionally,
can
increase
chlorophyll
content
defense-related
enzyme
more
effectively
than
its
enantiomer.
Therefore,
this
study
provides
basis
development
agricultural
chemicals.
Insects,
Journal Year:
2024,
Volume and Issue:
15(6), P. 440 - 440
Published: June 11, 2024
Fruit
flies
cause
substantial
economic
damage,
and
their
management
relies
primarily
on
chemical
insecticides.
However,
pesticide
resistance
has
been
reported
in
several
fruit
fly
species,
the
mitigation
of
which
is
crucial
to
enhancing
control.
Here,
we
assess
toxicity
a
novel
insecticide
(fluralaner)
common
(dinotefuran)
against
three
Bactrocera
dorsalis
(Hendel),
cucurbitae
(Coquillett),
tau
(Walker).
Both
pesticides
exhibit
robust
lethal
sublethal
effects
all
with
fluralaner
being
more
potent.
Fluralaner
dinotefuran
suppress
reproductive
capacities
survival
rates
flies.
at
50%
concentration,
stimulates
capacity
B.
rate
tau.
also
causes
significant
transgenerational
effects,
impacting
offspring
hatching
reducing
proportion
female
offspring.
Thus,
both
high
potential
for
controlling
application
should
be
tailored
according
species
variations
diverse
they
may
induce.
Collectively,
findings
this
study
outline
two
insecticides
flies,
helping
optimize
ensure
effective
resistance.
Neonicotinoids
are
among
the
most
used
pesticides
worldwide,
contributingconsiderably
to
successful
agricultural
production.
Dinotefuran
is
a
third
generation
neonicotinoid
which
considered
have
few
negative
effects
on
non-target
aquatic
invertebrates
and
vertebrates.
Little
information
available
consequences
of
exposure
microorganisms
dinotefuran,
but
we
suspected
that
dinotefuran
can
alter
metabolic
functionality
freshwater
microbial
community.
We
Biolog
EcoPlates
measure
how
riverine
epilithic
biofilm
community
catabolized
various
carbon
sources
after
dinotefuran.
The
results
provide
an
ecotoxicological
assessment
demonstrate
alters
metabolism
concentration
tested
here
based
environmentally
realistic
values,
implying
potential
communities.
Naunyn-Schmiedeberg s Archives of Pharmacology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 26, 2025
In
agriculture
and
public
health,
insecticides
are
vital
chemicals
that
help
manage
diseases
control
pests.
However,
their
extensive
use
has
raised
concerns
about
negative
consequences
on
both
humans
animals.
Pesticide
exposure
impacts
numerous
human
organs,
including
the
reproductive
system.
Infertility
is
caused
by
system
disorders,
which
why
they
have
received
a
lot
of
attention
in
recent
decades.
According
to
what
currently
known,
among
substances
may
lower
quality
semen
produced
exposed
workers.
The
mechanisms
this
action
still
unclear,
even
though
underlying
been
suggested.
With
an
emphasis
harmful
effects
male
processes,
review
provides
thorough
analysis
toxicity
profile
these
substances.
To
reduce
insecticides'
animal
health
direct
future
research
initiatives,
it
essential
comprehend
consequences.
