Pesticides impacts on human health and the environment with their mechanisms of action and possible countermeasures

Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e29128 - e29128

Published: April 1, 2024

Pesticides are chemical constituents used to prevent or control pests, including insects, rodents, fungi, weeds, and other unwanted organisms. Despite their advantages in crop production disease management, the use of pesticides poses significant hazards environment public health. Pesticide elements have now perpetually entered our atmosphere subsequently contaminated water, food, soil, leading health threats ranging from acute chronic toxicities. can cause toxicity if a high dose is inhaled, ingested, comes into contact with skin eyes, while prolonged recurrent exposure leads toxicity. produce different types toxicity, for instance, neurotoxicity, mutagenicity, carcinogenicity, teratogenicity, endocrine disruption. The pesticide formulation may depend on specific active ingredient presence synergistic inert compounds that enhance modify its Safety concerns need hour contemporary pesticide-induced hazards. effectiveness implementation current legislature providing ample protection human key concerns. This review explored comprehensive summary regarding updated impacts advanced safety legislation. Implementing regulations, proper training, education help mitigate negative promote safer more sustainable agricultural practices.

Language: Английский

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Toxicity analysis of endocrine disrupting pesticides on non-target organisms: A critical analysis on toxicity mechanisms

Toxicology and Applied Pharmacology, Journal Year: 2023, Volume and Issue: 474, P. 116623 - 116623

Published: July 4, 2023

Language: Английский

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Associations of chronic exposure to a mixture of pesticides and type 2 diabetes mellitus in a Chinese elderly population

Chemosphere, Journal Year: 2024, Volume and Issue: 351, P. 141194 - 141194

Published: Jan. 11, 2024

Language: Английский

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Endocrine Disruptors and Metabolic Changes: Impact on Puberty Control

Endocrine Practice, Journal Year: 2024, Volume and Issue: 30(4), P. 384 - 397

Published: Jan. 6, 2024

Language: Английский

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Unraveling the toxic link between pesticides and brain cancer: a review on molecular mechanisms, signaling pathways and future research trends

The Nucleus, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Language: Английский

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The association between gestational selective serotonin reuptake inhibitor (SSRI) treatment and newborn thyroid screen: a large-scale cohort study

BMC Pediatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 29, 2025

The diagnosis of depression or anxiety treated by SSRIs has become relatively common in women childbearing age. However, the impact gestational SSRI treatment on newborn thyroid function is lacking. We explored as measured National Newborn Screening (NBS) Program and identified contributory factors. An observational large-scale study mother-infant dyads liveborn infants delivered between 2011 2022. Israeli NBS dataset [total thyroxine (TT4) obtained 36-72 h after delivery] was linked with electronic medical records mothers their born at Lis Maternity Women's Hospital, to generate a unified database. MDClone big data platform utilized extract maternal, perinatal, neonatal characteristics from dyads. Only term without documented disease and/or chronic medication administration, except for SSRIs, were included order minimize potential confounding effects infant's function. Group stratification relied documentation treatment. variables interest pregnancy, delivery, perinatal Multivariable forward linear regression model applied evaluate explanatory total levels. Out 105,928 infant-mother dyads, 2321(2.2%) had been during pregnancy. SSRI-treated older (34.8 ± 4.7 vs 32.6 4.8 years, p < 0.001) higher pre-pregnancy body mass index (23.4 4.5 22.7 4.1, 0.001), but similar mean weight gain (13 kg) Cesarean delivery more among than general population (p 0.001). Infants lower WHO-classified birthweight z-scores (-0.25 0.93 -0.04 0.92, rate small-for-gestational-age (13.4% 8.2%, A multivariable revealed that pregnancy not significant contributor TT4 levels = 0.497). no direct effect upon newborn's adaptation hypothalamic-pituitary-thyroidal axis, several other maternal possibly

Language: Английский

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Identifying pesticides of high concern for ecosystem, plant, animal, and human health: A comprehensive field study across Europe and Argentina

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 948, P. 174671 - 174671

Published: July 14, 2024

The widespread and excessive use of pesticides in modern agricultural practices has caused pesticide contamination the environment, animals, humans, with confirmed serious health consequences. This study aimed to identify 20 most critical substances based on an analysis detection frequency (DF) median concentrations (MC) across environmental biological matrices. A sampling campaign was conducted 10 case sites Europe 1 Argentina, each encompassing conventional organic farming systems. We analysed 209 active a total 4609 samples. All ranked among were detected silicon wristbands worn by humans animals indoor dust from both Five them all Overall, higher values DF MC, including blood plasma recorded samples compared farms. differences between systems greater less animal human Ten farms eight Two those, systems, are classified as hazardous for mammals (acute). seven (dietary). Three carcinogens. Seven endocrine disruptors. Six substances, which five plasma, reproduction/development. Efforts needed elucidate unknown effects mixtures, it is crucial that such research also considers biocides banned constitute baseline adds effect used agriculture.

Language: Английский

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Low-dose bisphenol AF exerts slight effects on glycolipid metabolism but causes metabolic disorders under the stress of Western diet in mice

Environmental Pollution, Journal Year: 2025, Volume and Issue: 369, P. 125861 - 125861

Published: Feb. 13, 2025

Language: Английский

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Examining the Relationship Between Persistent Organic Pollutants and Metabolic-Associated Fatty Liver Disease: A Cross-Sectional Analysis Using NHANES Data

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Recently, the term Metabolic-Associated Fatty Liver Disease (MAFLD) has been adopted to better reflect underlying pathology and association with metabolic issues. Beyond dietary factors physical activity, previous studies have suggested that persistent organic pollutants (POPs), may contribute etiology of MAFLD; however, this disease can also develop at very low POP exposure levels, making it challenging discern their specific effect. This study aims investigate potential link between POPs, prevalence MAFLD. Data from National Health Nutrition Examination Survey (NHANES) was utilized for cross-sectional study. Participants were categorized based on MAFLD status levels various POPs measured in blood serum. Cox regression estimate adjusted ratio (aPR) used. Hazard Index (HI), Proportion Maximum Scaling (POMS), Toxicity Burden (TBI) applied assess mixtures. A total 4,224 participants included, 47 (33–65) years, 53.0% women, 50.1% had No significant sex differences observed main analysis regarding individual prevalence. However, sensitivity analyses revealed an inverse relationship certain prevalence, particularly women. Higher PCBs associated a lower highlighted effects pollutants, mixtures, sex-specific differences. The combined use HI, POMS, TBI provided more detailed risk assessment. Findings suggest biological stressors play roles how influence MAFLD, warranting further investigation into mechanisms health outcomes different ranges.

Language: Английский

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SPE-HPLC-DAD Dosage of Seven Neonicotinoids in Green Coffee

Molecules, Journal Year: 2025, Volume and Issue: 30(9), P. 1930 - 1930

Published: April 26, 2025

Green coffee is essential in many tropical economies. Its cultivation often necessitates using pesticides that can leave behind residues harmful to human health. To ensure consumer safety, the European Community has set strict maximum residue limits (ranging from 0.01 1.0 mg/kg) for green sold within Europe. However, lack of official testing methods neonicotinoids (NEOs) a problem, as laboratories must spend resources and time developing validating suitable analytical methods. This study developed validated method simultaneous analysis seven NEOs frequently used cultivation: acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam. The proposed methodology uses Strata®-X PRO cartridges (solid-phase extraction) remove interfering compounds present food matrix high-performance liquid chromatography (HPLC), equipped with diode array detector (DAD), determine NEOs. accuracy profile strategy method’s suitability intended application. NEO recovery rates above 97%; negligible effects (>93%); linearity quantification (R2 values 0.99); relative biases standard deviations below 5% 6%, respectively; an expected error rate less than 8% allowed consider reliable objectives. Because its low ecological impact simple execution, this be routine analyses.

Language: Английский

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