Drug-microbiota interactions: an emerging priority for precision medicine

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Oct. 9, 2023

Abstract Individual variability in drug response (IVDR) can be a major cause of adverse reactions (ADRs) and prolonged therapy, resulting substantial health economic burden. Despite extensive research pharmacogenomics regarding the impact individual genetic background on pharmacokinetics (PK) pharmacodynamics (PD), diversity explains only limited proportion IVDR. The role gut microbiota, also known as second genome, its metabolites modulating therapeutic outcomes human diseases have been highlighted by recent studies. Consequently, burgeoning field pharmacomicrobiomics aims to explore correlation between microbiota variation IVDR or ADRs. This review presents an up-to-date overview intricate interactions classical agents for systemic diseases, including cancer, cardiovascular (CVDs), endocrine others. We summarise how directly indirectly, modify absorption, distribution, metabolism, excretion (ADME) drugs. Conversely, drugs modulate composition function leading changes microbial metabolism immune response. discuss practical challenges, strategies, opportunities this field, emphasizing critical need develop innovative approach multi-omics, integrate various data types, genomic data, well translate lab into clinical practice. To sum up, represents promising avenue address improve patient outcomes, further is imperative unlock full potential precision medicine.

Language: Английский

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Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(2), P. 217 - 217

Published: Feb. 18, 2024

Infectious diseases have long posed a significant threat to global health and require constant innovation in treatment approaches. However, recent groundbreaking research has shed light on previously overlooked player the pathogenesis of disease-the human microbiome. This review article addresses intricate relationship between microbiome infectious unravels its role as crucial mediator host-pathogen interactions. We explore remarkable potential harnessing this dynamic ecosystem develop innovative strategies that could revolutionize management diseases. By exploring latest advances emerging trends, aims provide new perspective combating by targeting

Language: Английский

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Microplastic consumption induces inflammatory signatures in the colon and prolongs a viral arthritis

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 809, P. 152212 - 152212

Published: Dec. 7, 2021

Global microplastic (MP) contamination and the effects on environment are well described. However, potential for MP consumption to affect human health remains controversial. Mice consuming ≈80 μg/kg/day of 1 μm polystyrene MPs via their drinking water showed no weight loss, nor were detected in internal organs. The microbiome was also not significantly changed. did lead small transcriptional changes colon suggesting plasma membrane perturbations mild inflammation. challenged with arthritogenic chikungunya virus, leading a prolonged arthritic foot swelling that associated elevated Th1, NK cell neutrophil signatures. Immunohistochemistry significant increase ratio neutrophils monocyte/macrophages. picture emerges is reminiscent enteropathic arthritis, whereby thought activate innate lymphoid cells can inter alia migrate joint tissues promote

Language: Английский

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The Role of The Tumor Microbiome in Tumor Development and Its Treatment

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: July 15, 2022

Commensal bacteria and other microorganisms that reside in the human body are closely associated with development treatment of cancers. Recently, tumor microbiome (TM) has been identified a variety cancers such as pancreatic, lung, breast TM different compositions tumors effects on tumors. plays an important role formation microenvironment, regulation local immunity, modification cell biology, directly affects efficacy drug for is expected to be biomarker tumors, engineered tumor-targeting anti-cancer microbial agents (GEN-001) have This paper reviews relevant studies recent years describes its distribution correlation clinical features, effect research directions treatment.

Language: Английский

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Multiple health benefits of curcumin and its therapeutic potential

Environmental Science and Pollution Research, Journal Year: 2022, Volume and Issue: 29(29), P. 43732 - 43744

Published: April 20, 2022

Language: Английский

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Future regenerative medicine developments and their therapeutic applications

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 158, P. 114131 - 114131

Published: Dec. 18, 2022

Although the currently available pharmacological assays can cure most pathological disorders, they have limited therapeutic value in relieving certain disorders like myocardial infarct, peripheral vascular disease, amputated limbs, or organ failure (e.g. renal failure). Pilot studies to overcome such problems using regenerative medicine (RM) delivered promising data. Comprehensive investigations of RM zebrafish reptilians are necessary for better understanding. However, precise mechanisms remain poorly understood despite tremendous amount data obtained model investigating exact behind their capability. Indeed, understanding and application humans save millions lives from dying due potentially life-threatening events. Recent launched a revolution replacing damaged human organs via different approaches last few decades. The newly established branch (known as Regenerative Medicine aims enhance natural repair mechanisms. This be done through several advanced broad-spectrum technologies transplantation, tissue engineering, Scaffolds technology (support vascularization an extracellular matrix), stem cell therapy, miRNA treatment, development 3D mini-organs (organoids), construction artificial tissues nanomedicine bio-printers. Moreover, next decades, revolutionary will applied based on intelligence wireless exchange, soft biomaterials, nanorobotics, even living robotics capable self-repair. present work presents comprehensive overview that summarizes new future advances field RM.

Language: Английский

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Microbiota of the gastrointestinal tract: Friend or foe?

World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(1), P. 19 - 42

Published: Jan. 3, 2023

The gut microbiota is currently considered an external organ of the human body that provides important mechanisms metabolic regulation and protection. encodes over 3 million genes, which approximately 150 times more than total number genes present in genome. Changes qualitative quantitative composition microbiome lead to disruption synthesis key bacterial metabolites, changes intestinal barrier function, inflammation can cause development a wide variety diseases, such as diabetes, obesity, gastrointestinal disorders, cardiovascular issues, neurological disorders oncological concerns. In this review, I consider issues related role its influence on physiological pathological processes occurring body, potential new therapeutic strategies aimed at restoring microbiome. Herewith, it understand should be single biological system, where change one element will inevitably affect other components. Thus, study impact health only taking into account numerous factors, has not yet been fully elucidated.

Language: Английский

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Probiotics, Live Biotherapeutic Products (LBPs), and Gut-Brain Axis Related Psychological Conditions: Implications for Research and Dietetics

Probiotics and Antimicrobial Proteins, Journal Year: 2023, Volume and Issue: 15(4), P. 1014 - 1031

Published: May 24, 2023

Language: Английский

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Microbiota in Irritable Bowel Syndrome and Endometriosis: Birds of a Feather Flock Together—A Review

Microorganisms, Journal Year: 2023, Volume and Issue: 11(8), P. 2089 - 2089

Published: Aug. 15, 2023

Endometriosis and irritable bowel syndrome (IBS) are chronic conditions affecting up to 10% of the global population, imposing significant burdens on healthcare systems patient quality life. Interestingly, around 20% endometriosis patients also present with symptoms indicative IBS. The pathogenesis both these multifactorial remains be fully elucidated, but connections gut microbiota becoming more apparent. Emerging research underscores differences in composition between healthy individuals those suffering from either or Intestinal dysbiosis appears pivotal conditions, exerting an influence via similar mechanisms. It impacts intestinal permeability, triggers inflammatory reactions, initiates immune responses. Furthermore, it is entwined a bidirectional relationship brain, as part gut–brain axis, whereby influences influenced by mental health pain perception. Recent years have witnessed development microbiota-focused therapies, such low FODMAP diets, prebiotics, probiotics, antibiotics, fecal transplantation, designed tackle relieve symptoms. While promising, treatments inconsistent data, highlighting need for further research. This review explores evidence IBS endometriosis, underscoring role conditions. A deeper understanding this common mechanism may enable enhanced diagnostics therapeutic advancements.

Language: Английский

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Gut-Brain Axis: Role of Microbiome, Metabolomics, Hormones, and Stress in Mental Health Disorders

Cells, Journal Year: 2024, Volume and Issue: 13(17), P. 1436 - 1436

Published: Aug. 27, 2024

The influence of gut microbiome, metabolites, omics, hormones, and stress on general mental health is increasingly being recognized. Ancient cultures recognized the importance diet overall an individual. Western science modern scientific methods are beginning to unravel foundations mechanisms behind some ancient beliefs customs. organ itself, now thought almost all other organs, ranging from brain reproductive systems. Gut biological sex also a myriad conditions that range disorders, obesity, gastrointestinal cardiovascular diseases health. Here, we review history current understanding gut-brain axis bidirectional talk in various disorders with special emphasis anxiety depressive whose prevalence has increased by over 50% past three decades COVID-19 pandemic biggest risk factor last few years. vagal nerve important contributor this talk, but pathways contribute, most remain understudied. Probiotics containing

Language: Английский

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