Functional bioactive compounds in ginger, turmeric, and garlic

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Dec. 8, 2022

Nutrition plays a very important role in the health promotion of individuals and brought about global paradigm shift from pharmaceuticals to nutraceuticals. This is due high cost, non-availability, side effects associated with unregulated consumption pharmaceuticals. Over ages, nutraceuticals food products were reported contain bioactive compounds great physiological benefits. report reviews selected foods namely ginger ( Zingiber officinale ), turmeric Curcuma longa garlic Allium sativum ) as potential natural therapeutics for ailments cancer heart-related diseases. Analytical profiles, functional activities, characterization these discussed possible recommendations prospective treatment diseases using

Language: Английский

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Effects of dietary polyphenol curcumin supplementation on metabolic, inflammatory, and oxidative stress indices in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: July 14, 2023

Objective The aim was to conduct a systematic review and meta-analysis for assessing the effectiveness safety of dietary polyphenol curcumin supplement on metabolic, inflammatory, oxidative stress indices in patients with metabolic syndrome (MetS). Methods A comprehensive search clinical trials conducted following scientific databases: PubMed, SCOPUS, Cochrane Library, EMBASE, Web Science, China Biological Medicine. Randomized controlled (RCTs) evaluating efficacy MetS were identified. random-effects performed using inverse variance, expressed as mean difference (MD) 95% confidence interval (CI). markers that evaluated present study included waist circumference (WC), fasting blood sugar (FBS), systolic pressure (SBP), diastolic (DBP), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), tumor necrosis factor-a (TNF-a), interleukin 6 (IL-6), C-reactive protein (CRP), ultrasensitive c-reactive (hsCRP), malondialdehyde (MDA). By employing tool, RCTs assessed bias risk. Results total 785 participants from 13 included, intervention durations ranging 4 12 weeks. Compared control group, group had positive effects WC (MD = -2.16, CI: -3.78 -0.54, p 0.009, seven studies), FBS -8.6, -15.45 -1.75, 0.01, nine DBP -2.8, -4.53 - 1.06, 0.002, five HDL-C 4.98, 2.58 7.38, < 0.0001, eight TNF-a -12.97, -18.37 -7.57, 0.00001, two CRP 1.24, -1.71 -0.77, MDA -2.35, -4.47 -0.24, 0.03, three studies). These improvements statistically significant. Meanwhile, there no significant improvement SBP -4.82, -9.98 0.35, 0.07, six TG 1.28, -3.75 6.30, 0.62, IL-6 -1.5, -3.97 0.97, 0.23, or hsCRP -1.10, -4.35 2.16, 0.51, FBS, SBP, HDL-C, IL-6, CRP, hsCRP, relatively high heterogeneity. Conclusion Curcumin exhibited promising potential enhancing associated syndrome, including inflammation. However, additional studies are required confirm such findings since evidence is limited has Systematic registration https://www.crd.york.ac.uk/prospero , identifier CRD42022362553.

Language: Английский

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Therapeutic effects of curcumin liposomes and nanocrystals on inflammatory osteolysis: In vitro and in vivo comparative study

Pharmacological Research, Journal Year: 2023, Volume and Issue: 192, P. 106778 - 106778

Published: April 23, 2023

Curcumin could inhibit periprosthetic osteolysis induced by wear debris and adherent endotoxin, which commonly cause prosthesis loosening negatively influence the long-term survival of joint arthroplasty. However, its limited water solubility poor stability pose challenges for further clinical application. To address these issues, we developed curcumin liposomes intraarticular injection, as possess good lubricant capacity pharmacological synergy with curcumin. Additionally, a nanocrystal dosage form was prepared to enable comparison based on their ability disperse effectively. A microfluidic method used controllability, repeatability, scalability. The Box-Behnken Design employed screen formulations flow parameters, while computational fluid dynamics simulate mixing process predict formation liposomes. optimized (Cur-LPs) had size 132.9 nm an encapsulation efficiency 97.1%, whereas nanocrystals (Cur-NCs) 172.3 nm. Both Cur-LPs Cur-NCs inhibited LPS-induced pro-inflammatory polarization macrophages reduced expression secretion inflammatory factors. mouse air pouch model demonstrated that both forms attenuated cell infiltration fibrosis in subcutaneous tissues. Interestingly, anti-inflammatory effect more potent than Cur-NCs, vitro vivo, although cellular uptake quicker. In conclusion, results demonstrate have great potential treatment therapeutic is closely related liposomal form.

Language: Английский

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Pea Protein–Curcumin Interactions and Their Effects on In Vitro Protein Digestibility

ACS Food Science & Technology, Journal Year: 2024, Volume and Issue: 4(3), P. 711 - 718

Published: Feb. 15, 2024

This study examined the effect of interaction between pea protein isolate (PPI) and curcumin on in vitro digestibility. PPI (0.125 mg/mL) was mixed with different amounts (2–100 μM) curcumin. UV–vis spectral analysis showed that formed complexes curcumin, which reduced transmittance surface hydrophobicity increased average particle size. Fluorescence transmission electron microscopy imaging revealed formation amorphous aggregates after complexation. Nonreducing sodium dodecyl–sulfate polyacrylamide gel electrophoresis did not affect profile. However, digestibility-corrected amino acid score by up to 30.5%. The findings offer valuable insights into food-matrix interactions quality formulated food products protein-based nutraceutical delivery systems.

Language: Английский

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The Effects of Curcuminoids Supplementation on Serum Adipokines: An Umbrella Review of Meta‐Analyses of Randomized Controlled Trials

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

ABSTRACT This umbrella review of randomized clinical trials aims to provide a unique and detailed understanding curcumin's effects on adipokines, adding novel perspective the existing body research. We carried out thorough search international databases up April 2024, including MEDLINE, SciVerse Scopus, Clarivate Analytics Web Science. A random‐effects model was utilized evaluate impact curcuminoid adipokines. The incorporated meta‐analyses that examined supplementation presenting associated effect sizes (ES) confidence intervals (CI). applied GRADE AMSTAR (A Tool for Assessing Risk Bias in Systematic Reviews system) assess certainty evidence quality systematic reviews. Our analysis one meta‐analysis, 14 RCTs plus 1 RCT not included meta‐analyses, revealed significant impactful findings. found substantial increase serum adiponectin levels with supplementation, indicating positive (SMD: 0.9; 95% CI, 0.4 1.3, p < 0.001; I 2 = 92.2%). However, we did observe leptin. assessment supports curcuminoids moderate evidence, while leptin supported by low evidence. Curcuminoid significantly increases moderate‐quality has no provides as safety effectiveness enhancing without adverse effects, reassuring audience about their potential adipokine

Language: Английский

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Potential of curcumin and its derivatives, modern insights on the anticancer properties: a comprehensive overview

Zeitschrift für Naturforschung C, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract Globally, cancer is the top cause of mortality, placing a heavy load on medical system. One first known secondary metabolites curcumin, bioactive substance. This study aims to emphasize chemopreventive and chemotherapeutic properties curcumin its derivatives, therefore, offering important insights for possible creation certain supplemental medications treatment different cancers. Electronic Google databases, including scholar, ResearchGate, PubMed/Medline, ScienceDirect, were searched gather pertinent data about effects derivatives. Various studies have revealed diverse array significant biological effects. The majority investigations pertaining potential anticancer associated processes are currently in experimental preclinical stage lack sufficient clinical trial validate their findings. Clinical research further needed clarify molecular specific targeted action as well toxicity side humans, order open up new therapeutic avenues treating cancer.

Language: Английский

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Nanotechnology for Pediatric Retinoblastoma Therapy

Pharmaceuticals, Journal Year: 2022, Volume and Issue: 15(9), P. 1087 - 1087

Published: Aug. 31, 2022

Retinoblastoma is a rare, sometimes hereditary, pediatric cancer. In high-income countries this disease has survival rate approaching 100%, while in low- and middle-income the prognosis fatal for about 80% of cases. Depending on stage disease, different therapeutic protocols are applied. more advanced forms surgical removal entire globe its intraocular contents (enucleation) is, unfortunately, necessary, whereas other cases, conventional chemotherapy normally used. To overcome side-effects reduced efficacy traditional chemotherapic drugs, nanodelivery systems that ensure sustained drug release manage to reach target site have recently been developed. This review takes into account current use advances nanomedicine treatment retinoblastoma discusses nanoparticulate formulations contain drugs natural products. addition, future developments discussed.

Language: Английский

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Curcumin suppresses cell proliferation and reduces cholesterol absorption in Caco-2 cells by activating the TRPA1 channel

Lipids in Health and Disease, Journal Year: 2023, Volume and Issue: 22(1)

Published: Jan. 14, 2023

Curcumin (Cur) is a bioactive dietary polyphenol of turmeric with various biological activities against several cancers. Colorectal cancer (CRC) one the leading causes cancer-related deaths. Intestinal cholesterol homeostasis associated CRC. Chemotherapy for CRC related to varied adverse effects. Therefore, natural products anti-cancer properties represent potential strategy primary prevention CRC.The present study used Cur as therapeutic approach using Caco-2 cell line. The cells were treated different concentrations duration time and then proliferation ability was assessed Cell Counting Kit-8 5-Ethynyl-2'-deoxyuridine assays. Oil red O staining assay kit evaluate cellular lipid content outward transportation. Finally, protein expressions transport-related signal transduction molecules Western blot assay.Cur inhibited in dose- time-dependent manner by activating transient receptor cation channel subfamily A member 1 (TRPA1) channel. Activation TRPA1 led increased intracellular calcium, peroxisome proliferator-activated gamma (PPARγ) upregulation, subsequent downregulation specificity protein-1 (SP-1)/sterol regulatory element-binding protein-2 (SREBP-2)/Niemann-Pick C1-like (NPC1L1) signaling pathway-related proteins, finally reduced absorption cells.Cur inhibits reduces through Ca2+/PPARγ/SP-1/SREBP-2/NPC1L1 channel, suggesting that can be supplement In cells, first stimulates calcium influx further upregulates PPARγ downregulates SP-1/SREBP-2/NPC1L1 pathway, cholesterol. TRPA1, 1; NPC1L1, Niemann-Pick PPARγ, gamma; SP-1, protein-1; SREBP-2, sterol protein-2; Cur, curcumin.

Language: Английский

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Plant-derived nanovesicles as an emerging platform for cancer therapy

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 14(1), P. 133 - 154

Published: Sept. 3, 2023

Plant-derived nanovesicles (PDNVs) derived from natural green products have emerged as an attractive nanoplatform in biomedical application. They are usually characterized by unique structural and biological functions, such the bioactive lipids/proteins/nucleic acids therapeutics targeting groups, immune-modulation, long-term circulation. With rapid development of nanotechnology, materials, synthetic chemistry, PDNVs can be engineered with multiple functions for efficient drug delivery specific killing diseased cells, which represent innovative biomaterial high biocompatibility fighting against cancer. In this review, we provide overview state-of-the-art studies concerning cancer therapy. The original sources, methods obtaining PDNVs, composition structure introduced systematically. emphasis on featured application, inherent anticancer properties well strategies constructing multifunctional PDNVs-based nanomaterials will discussed detail. Finally, some scientific issues technical challenges promising options improving therapy discussed, expected to promote further clinical translation.

Language: Английский

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Copper in Gynecological Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(24), P. 17578 - 17578

Published: Dec. 17, 2023

Copper (Cu) is an essential micronutrient for the correct development of eukaryotic organisms. This metal plays a key role in many cellular and physiological activities, including enzymatic activity, oxygen transport, cell signaling. Although redox activity Cu crucial reactions, this property also makes it potentially toxic when found at high levels. Due to dual action Cu, highly regulated mechanisms are necessary prevent both deficiency accumulation since its dyshomeostasis may favor multiple diseases, such as Menkes' Wilson's neurodegenerative diabetes mellitus, cancer. As relationship between cancer has been most studied, we analyze how can affect three fundamental processes tumor progression: proliferation, angiogenesis, metastasis. Gynecological diseases characterized by prevalence, morbidity, mortality, depending on case, mainly include benign malignant tumors. The that promote their progression affected occur be similar. We crosstalk deregulation gynecological focusing therapeutic strategies derived from metal.

Language: Английский

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