Cancers,
Journal Year:
2024,
Volume and Issue:
16(5), P. 983 - 983
Published: Feb. 28, 2024
This
exploratory
narrative
review
paper
delves
into
the
intricate
interplay
between
per-
and
polyfluoroalkyl
substances
(PFAS)
exposure,
sociodemographic
factors,
influence
of
stressors
in
context
endometrial
cancer.
PFAS,
ubiquitous
environmental
contaminants
notorious
for
their
persistence
ecosystem,
have
garnered
attention
potential
to
disrupt
endocrine
systems
provoke
immune
responses.
We
comprehensively
examine
various
sources
PFAS
encompassing
household
items,
water,
air,
soil,
thus
shedding
light
on
multifaceted
routes
through
which
individuals
encounter
these
compounds.
Furthermore,
we
explore
such
as
income,
education,
occupation,
ethnicity/race,
geographical
location
relationship
cancer
risk.
also
investigated
role
stress
exposure
The
results
revealed
a
significant
impact
factors
both
levels
Stress
emerged
notable
contributing
factor
influencing
development
cancer,
further
emphasizing
importance
management
practices
overall
well-being.
By
synthesizing
evidence
from
diverse
fields,
this
underscores
need
interdisciplinary
research
targeted
interventions
address
complex
stressors,
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: March 19, 2024
Heavy
metals,
common
environmental
pollutants
with
widespread
distribution
hazards
and
several
health
problems
linked
to
them
are
distinguished
from
other
toxic
compounds
by
their
bioaccumulation
in
living
organisms.
They
pollute
the
food
chain
threaten
of
animals.
Biologically,
heavy
metals
exhibit
both
beneficial
harmful
effects.
Certain
essential
such
as
Co,
Mn,
Se,
Zn,
Mg
play
crucial
roles
vital
physiological
processes
trace
amounts,
while
others
like
As,
Pb,
Hg,
Cd,
Cu
widely
recognized
for
properties.
Regardless
functions,
an
excess
intake
all
beyond
tolerance
limit
can
lead
toxicity.
Animals
face
exposure
through
contaminated
feed
water,
primarily
a
result
anthropogenic
pollution.
After
ingestion
persist
body
extended
duration
nature
dictates
whether
they
induce
acute
or
chronic,
clinical
subclinical,
subtle
toxicities.
The
effects
disruption
cellular
homeostasis
generation
free
radicals
that
develop
oxidative
stress.
In
cases
metal
poisoning,
characteristic
symptoms
may
arise,
potentially
culminating
death
animals
corresponding
necropsy
findings.
Chronic
toxicities
manifest
decline
overall
condition
scoring
decrease
production
potential
Elevated
levels
consumable
animal
products
raise
public
concerns.
Timely
diagnosis,
targeted
antidotes,
management
strategies
significantly
mitigate
impact
on
livestock
health,
productivity,
reproductive
performance.
Frontiers in Veterinary Science,
Journal Year:
2023,
Volume and Issue:
10
Published: March 29, 2023
Toxicity
with
heavy
metals
has
proven
to
be
a
significant
hazard
several
health
problems
linked
it.
Heavy
bioaccumulate
in
living
organisms,
pollute
the
food
chain,
and
possibly
threaten
of
animals.
Many
industries,
fertilizers,
traffic,
automobile,
paint,
groundwater,
animal
feed
are
sources
contamination
metals.
Few
metals,
such
as
aluminum
(Al),
may
eliminated
by
elimination
processes,
but
other
like
lead
(Pb),
arsenic
(As),
cadmium
(Ca)
accumulate
body
leading
chronic
toxicity
Even
if
these
have
no
biological
purpose,
their
toxic
effects
still
present
some
form
that
is
damaging
its
appropriate
functioning.
Cadmium
(Cd)
Pb
negative
impacts
on
number
physiological
biochemical
processes
when
exposed
sub-lethal
doses.
The
nephrotoxic
Pb,
As,
Cd
well
known,
high
amounts
naturally
occurring
environmental
occupational
populations
exposures
an
adverse
relationship
between
kidney
damage
metal
exposure.
Metal
determined
absorbed
dosage,
route
exposure,
duration
whether
acute
or
chronic.
This
can
numerous
disorders
also
result
excessive
due
oxidative
stress
generated
free
radical
production.
concentration
decreased
through
various
procedures
including
bioremediation,
pyrolysis,
phytoremediation,
rhizofiltration,
biochar,
thermal
process.
review
discusses
few
mechanisms,
cattle
special
emphasis
kidneys.
Frontiers in Public Health,
Journal Year:
2023,
Volume and Issue:
11
Published: Feb. 14, 2023
Background
Infertility
has
been
confirmed
as
a
significant
medical
and
social
problem.
Heavy
metal
exposure
refers
to
risk
factor
for
infertility,
which
is
capable
of
damaging
the
reproductive
system
males
females.
However,
heavy
female
infertility
have
rarely
investigated.
The
aim
this
study
was
analyze
association
between
infertility.
Methods
A
cross-sectional
using
data
from
three
cycles
National
Health
Nutrition
Examination
Survey
(NHANES,
2013–2018)
performed.
Female
evaluated
by
positive
responses
question
rhq074
in
questionnaire.
Cadmium
(Cd),
lead
(Pb),
mercury
(Hg),
arsenic
(As)
levels
blood
or
urine
were
examined
inductively
coupled
plasma
mass
spectrometry.
correlation
analyzed
through
weighted
logistic
regression.
Results
total
838
American
women
aged
20–44
years
covered
study.
Among
all
participants,
112
(13.37%)
subjected
Urinary
Cd
urinary
As
significantly
higher
infertile
than
control
(
P
<
0.05,
0.05).
showed
with
prevalence
rose
increase
trend
=
0.045).
associated
some
regression
(Crude,
Q2:
OR
3.99,
95%
CI
1.82,
8.74,
Q3:
2.90,
1.42,
5.92.
Model
1,
3.68,
1.64,
8.27,
2.33,
1.13,
4.48.
2,
4.11,
1.63,
10.07,
2.44,
1.07,
5.53.
3,
3.77,
1.52,
9.35).
Moreover,
Pb
(OR
2.16),
1.68,
1.11,
2.55),
1.02,
1.00,
1.03)
positively
correlated
35–44
years.
1.67,
1.16,
2.40,
2.49)
1.54,
2.38)
BMI
≥25
Conclusions
increased
levels.
To
extent,
Blood/urine
related
advanced
age
overweight/obese
women.
results
need
be
further
validated
future
prospective
studies.
F1000Research,
Journal Year:
2025,
Volume and Issue:
14, P. 134 - 134
Published: Jan. 27, 2025
Heavy
metal
contamination
has
gradually
become
a
very
much
important
significant
global
issue
due
to
its
continual
existence
in
the
environment
and
bioaccumulation
ecosystems,
posing
deleterious
risks
human
health.
This
review
aims
investigate
sources,
pathways,
toxicological
impacts
of
heavy
metals
such
as
cadmium,
lead,
mercury,
arsenic,
elucidating
their
health
consequences
plausible
mitigation
strategies.
Furthermore,
explores
dual
origins
contamination;
natural
geological
processes
anthropogenic
activities
industrial
emissions,
mining,
agricultural
practices.
These
sip
into
soil,
water,
food
chains,
leading
bioaccumulation,
bio-magnification
causing
risks,
including
cardiovascular
diseases,
neurological
disorders,
reproductive
toxicity.
Additionally,
addition
indigenous
case
studies
from
Nigeria,
lead
poisoning
Zamfara
State
Great
Kwa
River
Cross
Rivers
underscores
disproportionate
impact
pollution
developing
nations.
reveal
socio-economic
environmental
dimensions
issue,
providing
contextual
understanding
region-specific
vulnerabilities
outcomes.
To
address
these
problems,
evaluates
already
existing
strategies,
chelation
therapy
phytoremediation,
while
proposing
sustainable,
cost-effective
solutions
for
reducing
exposure
mitigating
impacts.
It
emphasizes
importance
integrative
approaches
involving
policy,
community
engagement,
technological
innovations
fight
effectively.
In
conclusion,
this
seminar
contributes
toxicity,
giving
showcasing
insights
sources
implications
contamination.
By
integrating
theoretical
perspectives
with
practical
solutions,
provides
robust
framework
informing
policy
makers
advancing
sustainable
management
practices.
