Heliyon,
Journal Year:
2023,
Volume and Issue:
9(10), P. e20977 - e20977
Published: Oct. 1, 2023
Sustainable
dairy
farms
are
characterised
by
the
self-production
of
forage
for
animal
feed.
These
sometimes
located
near
industrial
areas,
entailing
a
risk
food
chain
contamination
with
hazardous
metals
and
polycyclic
aromatic
hydrocarbons
(PAHs).
Accordingly,
evaluating
impact
pollution
on
milk
is
great
interest.
In
this
study,
effects
factors
sustainable
from
43
possible
correlations
between
inorganic
elements
PAHs
were
studied.
Spearman's
correlation
principal
component
analysis
(PCA)
performed
milk.
Most
in
below
maximum
residual
limits
cadmium
(Cd)
lead
(Pb),
established
EU
2013/1275
2019/1869,
respectively.
However,
arsenic
(As)
mercury
(Hg)
levels
above
their
respective
(EU
2019/1869).
No
samples
exceeded
Pb
488/2014)
or
Cd
1881/2006)
products.
Heavy-weight
(HW-PAHs,
four
more
rings)
detected
but
not
samples,
HW-PAHs
positively
correlated
Zn
Cd.
addition,
some
(chromium
(Cr),
iron
(Fe),
As,
Hg,
Pb)
also
Interestingly,
no
found
pollutants
milk,
suggesting
that
these
have
low
transfer
rate
to
The
PCA
results
highlighted
predominant
contribution
global
variance
collected
at
different
distances
areas.
contributions
balanced
than
forages.
Finally,
when
potential
sources
included
negative
was
observed
former
concentrations
HW-PAHs,
Cd,
Zn,
thermal
power
plants
steel
factory
emissions
main
polluting
area.
Biomolecules,
Journal Year:
2023,
Volume and Issue:
13(12), P. 1768 - 1768
Published: Dec. 9, 2023
Recent
years
have
seen
an
increased
interest
in
the
role
of
oxidative
stress
(OS)
pregnancy.
Pregnancy
inherently
heightens
susceptibility
to
OS,
a
condition
fueled
by
systemic
inflammatory
response
that
culminates
elevated
presence
reactive
oxygen
species
(ROS)
and
nitrogen
(RNS)
circulatory
system.
The
amplified
OS
pregnancy
can
trigger
series
detrimental
outcomes
such
as
underdevelopment,
abnormal
placental
function,
host
complications,
including
pre-eclampsia,
embryonic
resorption,
recurrent
loss,
fetal
developmental
anomalies,
intrauterine
growth
restriction,
and,
extreme
instances,
death.
body’s
mitigate
uncontrolled
increase
RNS/ROS
levels
requires
trace
elements
take
part
non-enzymatic
enzymatic
defense
processes,
namely,
copper
(Cu),
zinc
(Zn),
manganese
(Mn),
selenium
(Se).
Determination
ROS
concentrations
poses
challenge
due
their
short
half-lives,
prompting
use
marker
proteins,
malondialdehyde
(MDA),
superoxide
dismutase
(SOD),
glutathione
peroxidase
(GPx),
reductase
(GR),
catalase
(CAT),
(GSH).
These
markers,
indicative
intensity,
offer
indirect
assessments
complications.
Given
limitations
conducting
experimental
studies
on
pregnant
women,
animal
models
serve
valuable
substitutes
for
in-depth
research.
This
review
delves
into
mechanism
underscores
pivotal
markers
evaluation.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: March 19, 2024
Heavy
metals,
common
environmental
pollutants
with
widespread
distribution
hazards
and
several
health
problems
linked
to
them
are
distinguished
from
other
toxic
compounds
by
their
bioaccumulation
in
living
organisms.
They
pollute
the
food
chain
threaten
of
animals.
Biologically,
heavy
metals
exhibit
both
beneficial
harmful
effects.
Certain
essential
such
as
Co,
Mn,
Se,
Zn,
Mg
play
crucial
roles
vital
physiological
processes
trace
amounts,
while
others
like
As,
Pb,
Hg,
Cd,
Cu
widely
recognized
for
properties.
Regardless
functions,
an
excess
intake
all
beyond
tolerance
limit
can
lead
toxicity.
Animals
face
exposure
through
contaminated
feed
water,
primarily
a
result
anthropogenic
pollution.
After
ingestion
persist
body
extended
duration
nature
dictates
whether
they
induce
acute
or
chronic,
clinical
subclinical,
subtle
toxicities.
The
effects
disruption
cellular
homeostasis
generation
free
radicals
that
develop
oxidative
stress.
In
cases
metal
poisoning,
characteristic
symptoms
may
arise,
potentially
culminating
death
animals
corresponding
necropsy
findings.
Chronic
toxicities
manifest
decline
overall
condition
scoring
decrease
production
potential
Elevated
levels
consumable
animal
products
raise
public
concerns.
Timely
diagnosis,
targeted
antidotes,
management
strategies
significantly
mitigate
impact
on
livestock
health,
productivity,
reproductive
performance.
Environmental Pollution,
Journal Year:
2024,
Volume and Issue:
348, P. 123732 - 123732
Published: March 8, 2024
The
gut-brain
axis
is
a
crucial
interface
between
the
central
nervous
system
and
gut
microbiota.
Recent
evidence
shows
that
exposure
to
environmental
contaminants,
such
as
heavy
metals,
can
cause
dysbiosis
in
microbiota,
which
may
affect
communication,
impacting
aspects
of
brain
function
behavior.
This
systematic
review
literature
aims
evaluate
whether
deleterious
effects
on
due
metal
could
be
mediated
by
changes
microbiota
profile.
Animal
studies
involving
metals
comparison
with
control
group
evaluated
neuropsychological
outcomes
and/or
molecular
along
analysis
composition
were
reviewed.
authors
independently
assessed
for
inclusion,
extracted
data
risk
bias
using
protocol
Systematic
Review
Center
Laboratory
Experimentation
(SYRCLE)
preclinical
studies.
A
search
3
databases
yielded
16
eligible
focused
lead
(n
=
10),
cadmium
1),
mercury
3),
manganese
combined
Pb
Mn
1).
animal
species
rats
7),
mice
4),
zebrafish
carp
1)
fruit
fly
Heavy
found
adversely
cognitive
function,
behavior,
neuronal
morphology.
Moreover,
was
associated
abundance
specific
bacterial
phyla,
Firmicutes
Proteobacteria,
play
roles
health.
In
some
studies,
these
alterations
correlated
learning
memory
impairments
mood
disorders.
interplay
suggests
induce
direct
indirect
through
contributing
neurotoxicity
development
However,
small
number
papers
under
makes
it
difficult
draw
definitive
conclusions.
Further
research
warranted
unravel
underlying
mechanisms
translational
implications
human
Ecotoxicology and Environmental Safety,
Journal Year:
2025,
Volume and Issue:
291, P. 117801 - 117801
Published: Feb. 1, 2025
Long-term
exposure
to
potentially
toxic
elements
(PTEs)
increases
carcinogenic
and
non-carcinogenic
risks
in
the
exposed
population.
The
current
study
was
conducted
with
aims
of
meta-analysis
concentrations
PTEs
including
Arsenic
(As),
Cadmium
(Cd),
Lead
(Pb),
Mercury
(Hg),
Nickel
(Ni)
Copper
(Cu)
water
resources
human
health
risk
assessment
for
adult
males
female
consumers
China.
Search
performed
international
databases
Web
Science,
Scopus,
PubMed,
Embase
Google
Scholar
(gery
literature)
from
January
1,
2005
April
2024.
concentration
meta-analyzed
using
random
effects
model
(surface
groundwater)
location
(urban
rural
locations)
subgroups.
Human
due
ingestion
dermal
contact
pathways
estimated
target
hazard
quintet
(THQ)
(CR)
One
hundred
twenty-six
papers
237
data-reports
(n
=
13,083)
were
included
this
study.
rank
order
based
on
pooled
As
(12.6530
µg/l)
>
Cu
(11.1810
µg/l)>
Ni
(2.4950
Pb
(2.0660
Cd
(0.5370
Hg
(0.3600
µg/l).
percentage
studies
higher
than
standard
limits
(28.37
%)
(16.67
(11.86
(9.91
(7.48
(2.38
%).
Pb,
Ni,
surface
groundwater
but
water.
high
(THQ
≥
1)
male
(30.49
(8.09
%)>
(6.90
(3.60
(3.39
(2.50
female,
(29.78
(2.70
(1.25
(TCR
1E-4)
(60.28
(33.33
(56.73
(29.93
Therefore,
reduce
especially
As,
continuous
monitoring
control
release
into
through
novel
approaches
is
recommended.
Human and Ecological Risk Assessment An International Journal,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 13
Published: Jan. 5, 2025
Heavy
metal
exposure
has
well-established
health
risks,
but
its
impact
on
all-cause
mortality
through
renal
function
remains
unclear.
This
study
used
data
from
1,342
participants
aged≥60
years
in
the
National
Health
and
Nutrition
Examination
Survey
(2005-2018).
A
cross-sectional
design
was
employed,
with
heavy
composite
scores
derived
using
least
absolute
shrinkage
selection
operator
regression.
Multivariate
Cox
proportional
hazards
models
assessed
relationship
between
mortality,
while
mediation
analysis
evaluated
role
of
estimated
glomerular
filtration
rate
(eGFR).
The
average
participant
age
69.4
years.
Higher
(CMES)
were
associated
older
age,
higher
smoking
rates,
increased
blood
lead
(Pb)
cadmium
(Cd)
levels.
CMES
significantly
(adjusted
HR=1.75,
95%
CI:1.04-2.96),
Kaplan-Meier
curves
showing
lower
survival
(p=0.02).
Pb
Cd
levels
independently
risk.
eGFR
negatively
correlated
HR=0.98,
CI:
0.97-0.99)
mediated
23.7%
CMES-mortality
relationship.
These
findings
suggest
that
increases
risk,
partly
impaired
function.
