Exposure Levels of Pyrethroids, Chlorpyrifos and Glyphosate in EU—An Overview of Human Biomonitoring Studies Published since 2000 DOI Creative Commons
Helle Raun Andersen, Loïc Rambaud, Margaux Riou

et al.

Toxics, Journal Year: 2022, Volume and Issue: 10(12), P. 789 - 789

Published: Dec. 15, 2022

Currently used pesticides are rapidly metabolised and excreted, primarily in urine, urinary concentrations of pesticides/metabolites therefore useful biomarkers for the integrated exposure from all sources. Pyrethroid insecticides, organophosphate insecticide chlorpyrifos, herbicide glyphosate, were among prioritised substances HBM4EU project comparable human biomonitoring (HBM)-data obtained Aligned Studies. The aim this review was to supplement these data by presenting additional HBM studies priority across partner countries published since 2000. We identified relevant (44 pyrethroids, 23 24 glyphosate) literature search using PubMed Web Science. Most Western Southern part EU lacking more than half HBM4EU-partner countries. Many regional with relatively small sample size few address residential occupational exposure. Variation urine sampling, analytical methods, reporting HBM-data hampered comparability results studies. Despite shortcomings, a widespread general population marked geographical differences indicated. findings emphasise need harmonisation methods future as initiated during HBM4EU.

Language: Английский

Glyphosate exposure and urinary oxidative stress biomarkers in the Agricultural Health Study DOI Creative Commons
Vicky C. Chang, Gabriella Andreotti, María Ospina

et al.

JNCI Journal of the National Cancer Institute, Journal Year: 2023, Volume and Issue: 115(4), P. 394 - 404

Published: Jan. 11, 2023

Glyphosate is the most widely applied herbicide worldwide, and its use has been associated with increased risks of certain hematopoietic cancers in epidemiologic studies. Animal vitro experiments suggest that glyphosate may induce oxidative stress, a key characteristic carcinogens; however, evidence human populations remains scarce. We investigated associations between exposure urinary stress biomarkers Biomarkers Exposure Effect Agriculture study, molecular subcohort Agricultural Health Study.

Language: Английский

Citations

45
Exposure to glyphosate in the United States: Data from the 2013–2014 National Health and Nutrition Examination Survey DOI
María Ospina,

André Schütze,

Pilar Morales-Agudelo

et al.

Environment International, Journal Year: 2022, Volume and Issue: 170, P. 107620 - 107620

Published: Nov. 4, 2022

Language: Английский

Citations

54
Occurrence and exposure assessment of glyphosate in the environment and its impact on human beings DOI
Juan P. Muñoz, Eduardo Silva-Pavez,

Diego Carrillo-Beltrán

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 231, P. 116201 - 116201

Published: May 19, 2023

Language: Английский

Citations

26
Glyphosate presence in human sperm: First report and positive correlation with oxidative stress in an infertile French population DOI Creative Commons

Claudine Vasseur,

Loïse Serra, Souleiman El Balkhi

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 278, P. 116410 - 116410

Published: May 1, 2024

Environmental exposure to endocrine disruptors, such as pesticides, could contribute a decline of human fertility. Glyphosate (GLY) is the main component Based Herbicides (GBHs), which are most commonly herbicides used in world. Various animal model studies demonstrated its reprotoxicity. In Europe, GLY authorization agriculture has been extended until 2034. Meanwhile toxicity humans still debate. The aims our study were firstly analyse concentration and metabolite, amino-methyl-phosphonic acid (AMPA) by LC/MS-MS seminal blood plasma an infertile French men population (n=128). We secondly determined Total Antioxidant Status (TAS) Oxidant (TOS) using commercial colorimetric kits some oxidative stress biomarkers including malondialdehyde (MDA) 8-hydroxy-2′-deoxyguanosine (8-OHdG) ELISA assays. next analysed potential correlations between sperm parameters (sperm concentration, progressive speed, anormal forms). Here, we detected for first time significant proportions showed that was four times higher than those observed plasma. At opposite, AMPA undetectable. also strong positive correlation concentrations 8-OHdG concentrations, latter reflecting DNA impact. addition, TOS, Oxidative Stress Index (OSI) (TOS/TAS), MDA significantly with glyphosate plasma, respectively. Taken together, results suggest negative impact on reproductive health possibly his progeny. A precaution principle should be applied at actual discussion GBHs formulants uses Europe authorities.

Language: Английский

Citations

11
Glyphosate, Roundup and the Failures of Regulatory Assessment DOI Creative Commons

Eva Novotny

Toxics, Journal Year: 2022, Volume and Issue: 10(6), P. 321 - 321

Published: June 13, 2022

Roundup is the most widely used herbicide in agriculture. It contains glyphosate as ‘active ingredient’, together with formulants. There are various versions of Roundup, somewhat different effects depending on Most genetically-modified crops designed to tolerate thus allowing spraying against weeds during growing season crop without destroying it. Having been so heavily used, this now found soil, water, air, and even humans worldwide. may also remain a residue edible crops. Many studies have harm environment health, making it imperative regulate use ensure that its formulations pose no danger when long-term. Unfortunately, regulators only assess glyphosate, ignore toxicity formulants, which can be far more toxic than active ingredient. This omission violation ruling by Court Justice European Union. close ties between industry they supposed regulate. Objectionable practices include ‘revolving doors’ industry, heavy reliance unpublished papers produced while dismissing published independent scientists, strong covert influence regulatory process industry. Although paper focuses Union (EU), situation much same United States.

Language: Английский

Citations

35
Does Glyphosate Affect the Human Microbiota? DOI Creative Commons
Pere Puigbò, L. Leino, Miia J. Rainio

et al.

Life, Journal Year: 2022, Volume and Issue: 12(5), P. 707 - 707

Published: May 9, 2022

Glyphosate is the world's most widely used agrochemical. Its use in agriculture and gardening has been proclaimed safe because humans other animals do not have target enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS). However, increasing numbers of studies demonstrated risks to shikimate metabolic pathway present many microbes. Here, we assess potential effect glyphosate on healthy human microbiota. Our results demonstrate that more than one-half microbiome are intrinsically sensitive glyphosate. further empirical needed determine

Language: Английский

Citations

34
Low-dose glyphosate exposure alters gut microbiota composition and modulates gut homeostasis DOI Creative Commons

Peter Lehman,

Nicole Cady, Sudeep Ghimire

et al.

Environmental Toxicology and Pharmacology, Journal Year: 2023, Volume and Issue: 100, P. 104149 - 104149

Published: May 15, 2023

Language: Английский

Citations

18
Exposure to Pesticides and Breast Cancer in an Agricultural Region in Brazil DOI Creative Commons
Carolina Panis, Luciano Zanetti Pessôa Candiotto, Shaiane Carla Gaboardi

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(24), P. 10470 - 10481

Published: June 6, 2024

Rural workers are disproportionally exposed to pesticides and might be at an increased risk of developing chronic diseases. Here, we investigated the impact pesticide exposure on breast cancer (BC) disease profile in rural female workers. This is a case-control study that prospectively included 758 individuals. The was conducted Southwest region Paraná state Brazil, characterized by family-based agriculture intensive use pesticides. We found this has 41% higher BC diagnosis rate 14% mortality than mean rates as well trade volume about 6 times national average. showed substantial population even women who did not work fields but performed equipment decontamination clothes washing male partners worked had urine samples positive for glyphosate, atrazine, and/or 2,4-D. crude association significantly among (OR: 1.58, 95% CI 1.18–2.13). Adjusted analyses lower nonstatistically significant 1.30, 41 0.87–1.95). Stratification lymph node metastasis (adjusted OR: 2.19, 1.31–3.72) Our findings suggest populations with more aggressive draw attention need monitor potentially field or home.

Language: Английский

Citations

7
Agricultural activities and risk of Alzheimer’s disease: the TRACTOR project, a nationwide retrospective cohort study DOI Creative Commons
Pascal Petit, Elise Gondard, Gérald Gandon

et al.

European Journal of Epidemiology, Journal Year: 2024, Volume and Issue: 39(3), P. 271 - 287

Published: Jan. 10, 2024

Data regarding Alzheimer's disease (AD) occurrence in farming populations is lacking. This study aimed to investigate whether, among the entire French farm manager (FM) workforce, certain agricultural activities are more strongly associated with AD than others, using nationwide data from TRACTOR (Tracking and monitoring occupational risks agriculture) project. Administrative health insurance (digital electronic health/medical records claims) for over period 2002-2016, on mainland France were used estimate risk of 26 Cox proportional hazards model. For each analysis (one activity), exposed group included all FMs that performed activity interest (e.g. crop farming), while reference who did not carry out never farmed crops between 2002 2016). There 5067 cases 1,036,069 worked at least one year 2016. Analyses showed higher (hazard ratio (HR) = 3.72 [3.47-3.98]), viticulture (HR 1.29 [1.18-1.42]), fruit arboriculture 1.36 [1.15-1.62]). By contrast, lower found several animal types, particular poultry rabbit 0.29 [0.20-0.44]), ovine caprine 0.50 [0.41-0.61]), mixed dairy cow 0.46 [0.37-0.57]), 0.67 [0.61-0.73]), pig 0.30 [0.18-0.52]). shed some light association a wide range population.

Language: Английский

Citations

6
Amino acid modified graphene oxide for the simultaneous capture and electrochemical detection of glyphosate DOI Creative Commons
Giulia Moro, Sara Khaliha,

Angela Pintus

et al.

Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 36, P. 101936 - 101936

Published: Jan. 30, 2024

Amino acid modified graphene oxide derivatives (GO-AA) are herein proposed as active materials for the capture and consequent electrochemical detection of organic pollutants in aqueous media. Glyphosate (GLY), an herbicide present many water compartments, was chosen benchmark species to test effectiveness these its electroactive nature, allowing direct evidence event. l-Lysine, l-Arginine or l-Methionine were grafted on GO surface through epoxide ring opening reaction, promoting amino acids binding concomitant partial reduction GO. The synthetic process results a charge resistance drop from 8.1 KΩ 0.8–2.1 various GO-AA, supporting applicability sensing. resulting GO-Lysine, GO-Arginine GO-Methionine exploited GLY adsorption water. GO-Lysine found have strongest interaction with GLY, removal efficiency 76 % after 1 h, which is about two-fold higher than those granular activated carbon, industrial adsorbent. GO-AAs outperform pristine unmodified material also when capturing following GLY. showed best sensitivity allowed recognition even at concentration levels down 2 μg/L. Molecular dynamics simulations confirmed that enhanced performance this can be ascribed hydrogen bond salt bridge interactions between Lys moieties originated interactions.

Language: Английский

Citations

6