Maternal body condition affects the response of larval spined toads’ faecal microbiome to a widespread contaminant DOI Open Access
Sabrina Tartu, Nicolas Pollet,

Isabelle Clavereau

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 18, 2023

Abstract Glyphosate’s primary metabolite, aminomethylphosphonic acid (AMPA), is the most detected pollutant in surface waters. Recent studies have raised concerns about its toxicity, yet underlying mechanisms remain poorly understood. A disruption of gut microbiome, which plays a crucial role host health, could mediate adverse effects. We investigated impact AMPA exposure on microbiome spined toad tadpoles ( Bufo spinosus ). hypothesized that alter microbiota composition and these effects depend source. exposed to minute concentrations analyzed their faecal using 16S rRNA gene sequencing as proxy microbiota. decreased bacterial biomass affected community tadpole’s faeces. Furthermore, we observed interactions between maternal body condition Bacteroidota Actinobacteriota phyla abundances. This suggests effect early-life microbial colonizers influence response AMPA. These findings highlight importance considering when studying environmental contaminants. Further research needed elucidate long-term implications this alteration for amphibian health.

Language: Английский

Polyethylene microplastics induced gut microbiota dysbiosis leading to liver injury via the TLR2/NF-κB/NLRP3 pathway in mice DOI
Ran Xu,

Jing-wen Cao,

Hongli Lv

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 917, P. 170518 - 170518

Published: Jan. 28, 2024

Language: Английский

Citations

38
Overview of human health effects related to glyphosate exposure DOI Creative Commons

Flavia Silvia Galli,

Marta Mollari,

Valentina Tassinari

et al.

Frontiers in Toxicology, Journal Year: 2024, Volume and Issue: 6

Published: Sept. 18, 2024

Glyphosate is a chemical compound derived from glycine, marketed as broad-spectrum herbicide, and represents one of the most widely used pesticides in world. For long time, it was assumed that glyphosate harmless, either due to its selective enzymatic acting method on plants, because commercial formulations were believed contain only inert chemicals. spread environment, general population daily exposed via different routes, including consumption both plant, non-plant based foods. has been detected high amounts workers’ urine, but likewise bodily fluids, such blood maternal milk, also 60%–80% population, children. Considering massive presence, exposure could be considered health risk for humans. Indeed, 2015, IARC (International Agency Research Cancer) classified derivatives Group 2A, probable human carcinogens. In 2022, nevertheless, EFSA (European Food Safety Authority) stated available data did not provide sufficient evidence prove mutagenic/carcinogenic effects glyphosate. Therefore, European Commission (EC) decided renew approval another 10 years. The purpose this review examine scientific literature, focusing potential risks arising glyphosate, metabolites products (e.g., Roundup ® ), with particular regard mutagenic carcinogenic endocrine disrupter (ED) especially reproductive system.

Language: Английский

Citations

4
Glyphosate-based herbicide as a potential risk factor for breast cancer DOI
Lyvia Neves Rebello Alves,

Luiza Poppe Merigueti,

Matheus Correia Casotti

et al.

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 115404 - 115404

Published: March 1, 2025

Language: Английский

Citations

0
Are glyphosate or glyphosate-based herbicides linked to Metabolic dysfunction-associated steatotic liver disease (MASLD)? The weight of current evidence DOI

Luana Riechelman-Casarin,

Letícia Cardoso Valente, Rosemari Otton

et al.

Environmental Toxicology and Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 104705 - 104705

Published: April 1, 2025

Language: Английский

Citations

0
Effects of glyphosate exposure on intestinal microbiota, metabolism and microstructure: a systematic review DOI
Amanda da Cunha Ignácio,

Andressa Maria dos Reis Guerra,

Thaiany Goulart de Souza e Silva

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(15), P. 7757 - 7781

Published: Jan. 1, 2024

Glyphosate is the most commercialized herbicide in Brazil and worldwide, this has become a worrying scenario recent years. In 2015 glyphosate was classified as potentially carcinogenic by World Health Organization, which opened avenues for numerous debates about its safe use regarding non-target species' health, including humans. This review aimed to observe impacts of formulations on gut microbiota, well microstructure animal metabolism. A systematic conducted based PRISMA recommendations, search original articles performed Pubmed/Medline, Scopus Web Science databases. The risk bias studies assessed using SYRCLE strategy. Our findings revealed that are able induce intestinal dysbiosis altering bacterial metabolism, permeability, mucus secretion, causing damage microvilli lumen. Additionally, immunological, enzymatic genetic changes were also observed models. At metabolic level, lipid energy circulatory system, cofactor vitamin replication, repair, translation processes. context, we pointed out these alterations, caused glyphosate-based herbicides, can lead systemic diseases, such Crohn's disease Alzheimer's disease.

Language: Английский

Citations

3
Associations between urine glyphosate levels and metabolic health risks: insights from a large cross-sectional population-based study DOI Creative Commons

Sarah Otaru,

Laura Jones, David O. Carpenter

et al.

Environmental Health, Journal Year: 2024, Volume and Issue: 23(1)

Published: June 27, 2024

Abstract Background The prevalence of metabolic syndrome (MetS) in American adults increased from 37.6% the 2011–12 period to 41.8% 2017–2018. Environmental exposure, particularly common compounds such as glyphosate, has drawn increasing attention a potential risk factor. Methods We employed three cycles data (2013–2018) National Health and Nutrition Examination Survey (NHANES) cross-sectional study examine associations between urine glyphosate measurements MetS incidence. first created score using exploratory factor analysis (EFA) International Diabetes Federation (IDF) criteria for MetS, with 2013–2018 NHANES cycles, validated this independently on an additional associated metric, albumin-to-creatinine (ACR) ratio. was via machine learning approach predicting ACR binary classification then used multivariable regression test association quartile-categorized exposure score. Results In adjusted regressions, regressions showed significant inverted U-shaped or saturating dose‒response profile, often largest effect exposures quartile 3. Exploration modification by sex, race, age category revealed differences race age, older people (aged > 65 years) non-Hispanic African participants showing larger sizes all quartiles. Conclusions found that urinary concentration is significantly statistical designed predict status dose–response coefficient nonlinear, advanced American, Mexican other Hispanic exhibiting greater sizes.

Language: Английский

Citations

3
Glyphosate exposure, muscular health and functional limitations in middle-aged and older adults DOI Creative Commons

Sara Jauregui-Zunzunegui,

Fernando Rodríguez‐Artalejo, María Téllez-Plaza

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: 251, P. 118547 - 118547

Published: March 6, 2024

Glyphosate is the most widely used herbicide worldwide, both in domestic and industrial settings. Experimental research animal models has demonstrated changes muscle physiology reduced contractile strength associated with glyphosate exposure, while epidemiological studies have shown associations between exposure adverse health outcomes critical biological systems affecting function. This study data from a nationally representative survey of non-institutionalized U.S. general population (NHANES, n = 2132). Urine concentrations were determined by ion chromatography tandem mass spectrometry. Hand grip (HGS) was measured using Takei Dynamometer, relative estimated as ratio HGS dominant hand appendicular lean (ALM) to body index (ALMBMI) ratio. Low low defined 1 sex-, age- race-specific SD below mean. Physical function limitations identified significant difficulty or incapacity various activities. In fully-adjusted models, Mean Differences (MD) 95% confidence intervals [95%CI] per doubling increase −0.55 [-1.09, −0.01] kg for hand, −0.90 [-1.58. −0.21] HGS/ALMBMI. The Odds Ratios (OR) [95% CI] HGS, functional 1.27 [1.03, 1.57] HGS; 1.43 [1.05; 1.94] 1.33 [1.08, 1.63] stooping, crouching kneeling difficulty; 1.17 [0.91, 1.50] lifting carrying items weighting up 10 pounds 1.21 [1.01, 1.40] standing armless chair 1.47 [1.05, 2.29] ascending ten steps without pause difficulty. may be risk factor decreased increased physical limitations. More investigating influence this other environmental pollutants on aging are needed.

Language: Английский

Citations

2
Pesticides and the Gut Microbiota: Implications for Parkinson’s Disease DOI

Nabanita Ghosh,

Krishnendu Sinha, Parames C. Sil

et al.

Chemical Research in Toxicology, Journal Year: 2024, Volume and Issue: 37(7), P. 1071 - 1085

Published: July 3, 2024

Parkinson's disease (PD) affects more people worldwide than just aging alone can explain. This is likely due to environmental influences, genetic makeup, and changes in daily habits. The develops a complex way, with movement problems caused by Lewy bodies the loss of dopamine-producing neurons. Some research suggests might start gut, hinting at connection between these structures gut health PD patients. These patients often have different bacteria metabolites. Pesticides are known increase risk PD, evidence showing they harm dopamine Long-term exposure pesticides food affect barrier, bacteria, blood-brain but exact link still unknown. review looks how separately influence development progression, highlighting harmful effects bacteria. We examined interaction patients, summarizing cause imbalances resulting changes, their overall on prognosis.

Language: Английский

Citations

2
Gestational urinary concentrations of glyphosate and aminomethylphosphonic acid in relation to preterm birth: the MIREC study DOI Creative Commons
Jillian Ashley‐Martin,

Leonora Marro,

James Owen

et al.

Journal of Exposure Science & Environmental Epidemiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Language: Английский

Citations

2
Glyphosate as a direct or indirect activator of pro-inflammatory signaling and cognitive impairment DOI Creative Commons
Yukitoshi Izumi,

Kazuko A. O’Dell,

Charles F. Zorumski

et al.

Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(10), P. 2212 - 2218

Published: Dec. 21, 2023

Glyphosate-based herbicides are widely used around the world, making it likely that most humans have significant exposure. Because of habitual exposure, there concerns about toxicity including neurotoxicity could result in neurological, psychiatric, or cognitive impairment. We recently found a single injection glyphosate inhibits long-term potentiation, cellular model learning and memory, rat hippocampal slices dissected 1 day after injection, indicating glyphosate-based can alter function. adversely affect function either indirectly and/or directly. Indirectly, gut microbiota, if dysbiosis results endotoxemia (leaky gut), infiltrated bacterial by-products such as lipopolysaccharides activate pro-inflammatory cascades. Glyphosate also directly trigger Indeed, we observed acute exposure potentiation slices. Interestingly, direct inhibition by appears to be similar lipopolysaccharides. There several possible measures control neuroinflammation caused glyphosate. Dietary intake polyphenols, quercetin, which overcome inhibitory effect on one effective strategy. The aim this narrative review is discuss mechanisms underlying following means identify potential treatments.

Language: Английский

Citations

5