Cancers,
Journal Year:
2024,
Volume and Issue:
16(21), P. 3703 - 3703
Published: Nov. 1, 2024
Humans
cannot
avoid
plastic
exposure
due
to
its
ubiquitous
presence
in
the
natural
environment.
The
waste
generated
is
poorly
biodegradable
and
exists
form
of
MPs,
which
can
enter
human
body
primarily
through
digestive
tract,
respiratory
or
damaged
skin
accumulate
various
tissues
by
crossing
biological
membrane
barriers.
There
an
increasing
amount
research
on
health
effects
MPs.
Most
literature
reports
focus
impact
plastics
respiratory,
digestive,
reproductive,
hormonal,
nervous,
immune
systems,
as
well
metabolic
MPs
accumulation
leading
epidemics
obesity,
diabetes,
hypertension,
non-alcoholic
fatty
liver
disease.
xenobiotics,
undergo
ADMET
processes
body,
i.e.,
absorption,
distribution,
metabolism,
excretion,
are
not
fully
understood.
Of
particular
concern
carcinogenic
chemicals
added
during
manufacturing
adsorbed
from
environment,
such
chlorinated
paraffins,
phthalates,
phenols,
bisphenols,
be
released
when
absorbed
body.
continuous
increase
NMP
has
accelerated
SARS-CoV-2
pandemic
there
was
a
need
use
single-use
products
daily
life.
Therefore,
urgent
diagnose
problems
related
MP
detection.
Sustainability,
Journal Year:
2023,
Volume and Issue:
15(14), P. 10821 - 10821
Published: July 10, 2023
In
recent
years,
there
has
been
mounting
concern
about
the
bearing
of
microplastics
on
human
health
and
comprehensive
natural
environment.
These
particles
come
from
a
variety
sources,
such
as
soaps,
personal
care
products,
rundown
bigger
plastic
items.
The
impacts
marine
life
other
ecosystems
are
substantial,
including
ingestion
by
animals,
interference
with
their
reproductive
systems,
even
death.
economic
implications
also
significant,
industries,
fishing
tourism
being
affected
presence
in
Exposure
to
can
pose
potential
risks
humans,
respiratory
digestive
problems,
well
disrupt
sleep,
contribute
obesity,
increase
risk
diabetes.
To
address
this
issue,
policies
initiatives
have
put
place
reduce
microplastic
pollution,
but
challenges
that
need
be
overcome,
lack
awareness,
limited
resources,
ineffective
regulations.
Further
research
is
needed
fully
understand
our
develop
effective
strategies
mitigate
problem.
article,
we
discussed
requirement
multifaceted
approach
reducing
use,
promoting
proper
disposal
recycling
waste,
developing
innovative
technologies
for
capturing
removing
environment,
raising
public
implementing
regulations
policies.
It
only
through
concerted
efforts
collaboration
between
individuals,
governments
threat
tackled.
Archives of Toxicology,
Journal Year:
2023,
Volume and Issue:
98(1), P. 1 - 73
Published: Oct. 19, 2023
Bisphenol
A
(BPA)
is
an
endocrine-disrupting
chemical
(EDC)
and
one
of
the
most
produced
synthetic
compounds
worldwide.
BPA
can
be
found
in
epoxy
resins
polycarbonate
plastics,
which
are
frequently
used
food
storage
baby
bottles.
However,
bind
mainly
to
estrogen
receptors,
interfering
with
various
neurologic
functions,
its
use
a
topic
significant
concern.
Nonetheless,
neurotoxicity
has
not
been
fully
understood
despite
numerous
investigations
on
disruptive
effects.
Therefore,
this
review
aims
highlight
recent
studies
implications
system.
Our
findings
suggest
that
exposure
impairs
structural
molecular
brain
changes,
promoting
oxidative
stress,
changing
expression
levels
several
crucial
genes
proteins,
destructive
effects
neurotransmitters,
excitotoxicity
neuroinflammation,
damaged
blood-brain
barrier
function,
neuronal
damage,
apoptosis
effects,
disruption
intracellular
Ca
Journal of Advanced Research,
Journal Year:
2023,
Volume and Issue:
56, P. 31 - 41
Published: March 17, 2023
It
has
been
shown
that
polystyrene
nanoplastic
(PS-NP)
exposure
induces
toxicity
in
the
lungs.
This
study
aims
to
provide
foundational
evidence
corroborate
ferroptosis
and
abnormal
HIF-1α
activity
are
main
factors
contributing
pulmonary
dysfunction
induced
by
PS-NP
exposure.
Fifty
male
female
C57BL/6
mice
were
exposed
distilled
water
or
100
nm
200
PS-NPs
via
intratracheal
instillation
for
7
consecutive
days.
Hematoxylin
eosin
(H&E)
Masson
trichrome
staining
performed
observe
histomorphological
changes
To
clarify
mechanisms
of
PS-NP-induced
lung
injury,
we
used
μg/ml,
μg/ml
400
treat
human
bronchial
epithelial
cell
line
BEAS-2B
24
h.
RNA
sequencing
(RNA-seq)
cells
was
following
The
levels
glutathione,
malondialdehyde,
ferrous
iron
(Fe2+),
reactive
oxygen
species
(ROS)
measured.
expression
ferroptotic
proteins
detected
tissues
Western
blotting.
blotting,
immunohistochemistry,
immunofluorescence
evaluate
HIF-1α/HO-1
signaling
pathway
activity.
H&E
revealed
substantial
perivascular
lymphocytic
inflammation
a
bronchiolocentric
pattern,
demonstrated
critical
collagen
deposits
lungs
after
RNA-seq
differentially
expressed
genes
PS-NP-exposed
enriched
lipid
metabolism
ion
binding
processes.
After
exposure,
Fe2+,
ROS
increased,
but
glutathione
level
decreased.
altered
significantly.
These
results
verified
led
injury
through
ferroptosis.
Finally,
discovered
played
an
important
role
regulating
injury.
caused
activating
pathway,
eventually
Chemosphere,
Journal Year:
2023,
Volume and Issue:
321, P. 138032 - 138032
Published: Feb. 3, 2023
Microplastics
(MPs)
have
been
found
in
a
wide
range
of
animal
species
including
humans.
The
detection
MPs
human
lungs
suggests
that
humans
inhale
airborne
microplastics
(AMPs).
Although
birds
respire
more
efficiently
than
mammals
and
are
therefore
susceptible
to
air
pollution,
little
is
known
about
their
inhalation
exposure
MPs.
In
this
study,
we
analyzed
samples
isolated
from
the
several
wild
Japan
by
attenuated
total
reflection
(ATR)
imaging
method
micro-Fourier
transform
infrared
(μFTIR)
spectroscopy
clear
whether
AMPs
can
be
inhaled
accumulate
within
birds.
To
isolate
lung
rock
doves
(Columba
livia),
black
kites
(Milvus
migrans),
barn
swallows
(Hirundo
rustica)
euthanized
for
pest
control,
digestion
density
separation
were
performed.
After
each
sample
collected
on
an
alumina
filter
was
measured
ATR
using
μFTIR
spectroscopy,
physical
chemical
characteristics
detected
evaluated.
Six
3
22
samples.
Polypropylene
polyethylene
ethylene
vinyl
acetate
swallow.
Most
fragments
28.0-70.5
μm.
Our
results
demonstrated
addition
dietary
sources,
some
exposed
inhalation,
these
reach
lungs.
Microplastics,
Journal Year:
2023,
Volume and Issue:
2(3), P. 278 - 303
Published: Sept. 4, 2023
Microplastic
pollution
has
become
a
global
environmental
concern
with
detrimental
effects
on
ecosystems
and
human
health.
Effective
removal
of
microplastics
from
water
sources
is
crucial
to
mitigate
their
impacts.
Advanced
oxidative
processes
(AOPs)
have
emerged
as
promising
strategies
for
the
degradation
elimination
microplastics.
This
review
provides
comprehensive
overview
application
AOPs
in
water.
Various
AOPs,
such
photocatalysis,
ozonation,
Fenton-like
processes,
shown
significant
potential
microplastic
degradation.
These
generate
highly
reactive
species,
hydroxyl
radicals,
which
can
break
down
into
smaller
fragments
or
even
mineralize
them
harmless
byproducts.
The
efficiency
photocatalytic
oxidation
depends
several
factors,
including
choice
photocatalysts,
reaction
conditions,
physicochemical
properties
Furthermore,
this
discusses
challenges
associated
oxidation,
need
optimization
operating
parameters
formation
harmful
Overall,
offers
avenue
water,
contributing
preservation
aquatic
safeguarding
However,
further
research
needed
address
limitations
optimize
implementation
process
effective
sustainable
remediation.
Environmental Pollutants and Bioavailability,
Journal Year:
2024,
Volume and Issue:
36(1)
Published: Jan. 4, 2024
Groundwater,
a
crucial
freshwater
source
faces
increasing
pollution
from
microplastics
(MPs).
This
study
aims
to
comprehensively
review
the
aquifers,
sampling
and
analysis
methods,
levels,
polymer
types,
sizes
of
MPs
in
groundwater
worldwide
between
2017
2023.
Very
few
reports
exist
on
abundance,
type,
size,
other
characteristics
field.
The
tools,
sample
collection
quantities
used
for
field
varied
considerably
among
studies.
However,
efforts
enhance
our
understanding
MP
results
through
level
measurements,
on-site
water
quality
parameters,
ion
analysis,
blanks
have
been
limited.
mostly
indicated
higher
concentrations
urban
industrial
areas
landfill
sites,
whereas
lower
were
observed
with
minimal
human
influence.
are
predominantly
polypropylene
polyethylene.
Standardized
methods
needed
further
promote
research
facilitate
cross-comparisons.
