Recent advances in fungal xenobiotic metabolism: enzymes and applications

World Journal of Microbiology and Biotechnology, Journal Year: 2023, Volume and Issue: 39(11)

Published: Sept. 2, 2023

Abstract Fungi have been extensively studied for their capacity to biotransform a wide range of natural and xenobiotic compounds. This versatility is reflection the broad substrate specificity fungal enzymes such as laccases, peroxidases cytochromes P450, which are involved in these reactions. review gives an account recent advances understanding metabolism drugs pollutants dyes, agrochemicals per- poly-fluorinated alkyl substances (PFAS), describes key biotransformation. The potential fungi bioremediation polluted environments biocatalytic production important compounds also discussed.

Language: Английский

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Biotransformation of fluorinated drugs and xenobiotics by the model fungus Cunninghamella elegans

Methods in enzymology on CD-ROM/Methods in enzymology, Journal Year: 2024, Volume and Issue: unknown, P. 251 - 285

Published: Jan. 1, 2024

Language: Английский

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Fungi as versatile biocatalytic tool for treatment of textile wastewater effluents

Environmental Sciences Europe, Journal Year: 2024, Volume and Issue: 36(1)

Published: Oct. 17, 2024

Abstract Textile wastewater poses a significant environmental challenge, primarily due to the presence of diverse contaminants, especially textile dyes. Untreated release these effluents directly into aquatic systems can lead esthetic degradation, eutrophication, reduced photosynthetic activity, and accumulation hazardous substances. Although conventional treatment methods are employed for reducing contaminant load in effluents, they often less efficient, thus prompting exploration innovative alternatives. Current review highlights myco-remediation as an inexpensive, promising environmentally sustainable solution. Fungi, with their decontamination mechanisms such biosorption, biotransformation, immobilization, prove effective heavy metals, persistent organic pollutants, emerging levels present However, more research effort is needed apply biodegradation strategy decompose completely “forever chemicals” per‐ polyfluorinated alkyl Fungi play key role degrading decolorizing dyes biocatalytic activity mediated by production oxidative enzymes, laccases, lignin peroxidases, manganese well dye adsorption capabilities. This comprehensive concentrates on fungi-based remediation including employ. While most studies concentrate effluent treatment, this also explores concurrent utilization biomass growth kinetics efficient reduction pollutant concentrations. Further, current work showed data optimization conditions pH, temperature nutrient requirements that decontamination.

Language: Английский

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Aerobic or anaerobic? Microbial degradation of per- and polyfluoroalkyl substances: A review

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136173 - 136173

Published: Oct. 18, 2024

Language: Английский

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Elucidating the degradation mechanisms of perfluorooctanoic acid and perfluorooctane sulfonate in various environmental matrices: a review of green degradation pathways

Environmental Geochemistry and Health, Journal Year: 2024, Volume and Issue: 46(9)

Published: July 29, 2024

Language: Английский

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Fungi for Sustainable Pharmaceutical Remediation: Enzymatic Innovations, Challenges, and Applications—A Review

Processes, Journal Year: 2025, Volume and Issue: 13(4), P. 1034 - 1034

Published: March 31, 2025

The extensive use of pharmaceuticals in human and veterinary medicine has led to their persistent environmental release, posing ecological public health risks. Major sources include manufacturing effluents, excretion, aquaculture, improper disposal, contributing bioaccumulation ecotoxicity. Mycoremediation is the fungal-mediated biodegradation pharmaceuticals, offers a promising sustainable approach mitigate pharmaceutical pollution. Studies have reported that certain fungal species, including Trametes versicolor Pleurotus ostreatus, can degrade up 90% contaminants, such as diclofenac, carbamazepine, ibuprofen, within days weeks, depending on conditions. Fungi produce range extracellular enzymes, laccases peroxidases, alongside intracellular enzymes like cytochrome P450 monooxygenases, which catalyze transformation complex compounds. These play an essential role modifying, detoxifying, mineralizing xenobiotics, thereby reducing persistence toxicity. effectiveness biotransformation influenced by factors substrate specificity, enzyme stability, Optimal degradation typically occurs at pH 4.5–6.0 temperatures 20–30 °C. Recent advancements engineering, immobilization techniques, bioreactor design improved catalytic efficiency process feasibility. However, scaling fungal-based remediation systems for large-scale applications remains challenge. Addressing these limitations with synthetic biology, metabolic other biotechnological innovations could further enhance enzymatic pharmaceuticals. This review highlights innovations, applications, challenges mycoremediation, emphasizing potential fungi transformative solution waste management.

Language: Английский

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Recent Advances in Microbial Enzyme Applications for Sustainable Textile Processing and Waste Management

Sci, Journal Year: 2025, Volume and Issue: 7(2), P. 46 - 46

Published: April 9, 2025

Microbial enzymes have revolutionised the textile industry by replacing harmful chemicals with eco-friendly alternatives, enhancing processes such as desizing, scouring, dyeing, finishing, and promoting water conservation while reducing pollution. This review explores role of like amylases, pectinases, cellulases, catalases, laccases, peroxidases in sustainable processing, focusing on their ability to mitigate environmental pollution from effluents. The also examines types characteristics hazardous waste evaluates traditional treatment methods, highlighting alternatives microbial enzyme treatments for effluent treatment. Recent advancements recombinant technology, including engineering immobilisation techniques enhance stability, reusability, catalytic performance, are explored. Additionally, potential extremozymes processing is explored, emphasising stability under harsh industrial conditions. Strategies through enzyme-based presented, principles circular economy. addresses challenges scalability, cost, process optimisation, proposing solutions outlining future directions widespread adoption production management. underscores transformative achieving greener manufacturing practices.

Language: Английский

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Advances on modification of photocatalyst for degradation/removal of organic pollutants from water

Cleaner Chemical Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 100176 - 100176

Published: April 1, 2025

Language: Английский

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Photocatalytic innovations in PFAS removal: Emerging trends and advances

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 980, P. 179567 - 179567

Published: May 1, 2025

Language: Английский

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Per- and polyfluoroalkyl substances sequestration by adsorption and photocatalysis: Technical challenges and pragmatic solution

Desalination and Water Treatment, Journal Year: 2024, Volume and Issue: 319, P. 100437 - 100437

Published: May 29, 2024

Consequent to the environmental persistence of Per- and polyfluoroalkyl substances (PFAS) their adverse effects on humans ecosystem, it is evident remove PFAS from drinking water aquatic ecosystem. This review enumerates significant contributions adsorption photocatalysis in removing while considering mechanism action. A comparative account sources water, toxicity, cost analysis, removal efficiencies, regeneration PFAS-spent adsorbents photocatalysts has been critically reviewed. Lastly, technical challenges associated with have highlighted considerations for future studies employing removal.

Language: Английский

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