Assessment of the potential toxic of naringenin nanoparticles using ex vivo and in silico models DOI Creative Commons
Gaetano Bruno Costa,

Bruna Franzon Rossi,

Byanca Pereira Moreira de Oliveira

et al.

Brazilian Journal of Biology, Journal Year: 2024, Volume and Issue: 84

Published: Jan. 1, 2024

Abstract Naringenin is a flavonoid known for its anti-inflammatory, antineoplastic, antiatherogenic, and antioxidant properties. However, it has poor technological characteristics limited bioavailability, which hinder use in food applications. Nanoencapsulation could address these limitations, but safety concerns regarding nanoengineered bioactives need to be resolved before they can effectively utilized as additives. The objective of this study was evaluate the potential cytotoxic, genotoxic, mutagenic effects both free encapsulated naringenin through vivo experiments using Allium cepa L. roots, along with pharmacokinetic molecular docking analyses. results showed that nanoparticles did not produce significant changes cell division index meristematic cells A. roots. Additionally, no alterations mitotic spindle or chromosomal breaks were observed. Molecular studies indicated binds active site catalase enzyme (CAT) competitive manner, while attaches away from superoxide dismutase (SOD2), demonstrating non-competitive interaction. ADMET property assessments suggested exhibits relatively low toxicity favorable oral administration. In summary, supports naringenin, particularly nanoencapsulated form, safe effective ingredient functional foods, provided nanoencapsulation are adequately addressed.

Language: Английский

Ecotoxicity of the Antimicrobials Methylparaben and Propylparaben in Mixture to Plants DOI

Thalia Aparecida Correia Vaz,

Lizandra de Souza Ratuchinski,

Sara Splendor Beijora

et al.

Water Air & Soil Pollution, Journal Year: 2024, Volume and Issue: 235(6)

Published: May 18, 2024

Language: Английский

Citations

4
Plastic particles in urban compost and their grain size distribution DOI

Hana Brťková,

Jana Růžičková,

Karolína Slamová

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 351, P. 124025 - 124025

Published: April 24, 2024

Language: Английский

Citations

2
Application of Salvinia biloba Raddi. in the Phytoextraction of the Emerging Pollutant Octocrylene in an Aquatic Environment DOI Open Access

Matheus A. S. Moura,

Gabrielle C. S. G. Nascimento,

Osvaldo Valarini

et al.

Processes, Journal Year: 2024, Volume and Issue: 12(8), P. 1631 - 1631

Published: Aug. 2, 2024

The phytotreatment technique, which has never been used to treat emerging compounds, is in this work measure the phytoextraction of octocrylene (OC) three concentrations (200, 400, and 600 μg/L OC) by Salvinia biloba Raddi. species proved be a phytoextractor accumulating OC floating leaves at 1,500,000 μg/kg treatment 200 1,050,000 OC. Chlorophyll synthesis was affected all concentrations, especially 400 μg/L, with chlorophyll a/b ratio less than 1. Enzymatic activity responded contaminant: CAT APX are inhibited submerged portions after 48 h, staying below 2.0E−6 μmol/min/μg protein. GPOX totally during experiment, SOD remains active μg/L. cytogenotoxic effects confirm were evaluated globally regulated tests Allium cepa bulbs germinal Lactuca sativa Avena fatua every h. These showed that 72 h phytoextraction, medium no longer seeds germinated above 30%, confirming capacity S. biloba. Thus, we can affirm aquatic environments contaminated

Language: Английский

Citations

2
Understudied and underestimated impacts of organic UV filters on terrestrial ecosystems DOI
Krishna Gautam, Sadasivam Anbumani

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 953, P. 176008 - 176008

Published: Sept. 3, 2024

Language: Английский

Citations

2
Prospecting toxicity of the avobenzone sunscreen in plants DOI

Sara Splendor Beijora,

Thalia Aparecida Correia Vaz,

Diego Espirito Santo

et al.

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(31), P. 44308 - 44317

Published: June 29, 2024

Language: Английский

Citations

1
Green extraction of valuable compounds from the byproduct of oil extraction from forage radish seed DOI Creative Commons
Natália Stevanato, Jaqueline Hoscheid, Ana Paula Peron

et al.

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 224, P. 120257 - 120257

Published: Dec. 17, 2024

Language: Английский

Citations

1
Toxicity of the emerging pollutants propylparaben and dichloropropylparaben to terrestrial plants DOI

Caio Okon,

Mylena Bathke Rocha,

Lizandra de Souza Ratuchinski

et al.

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(33), P. 45834 - 45846

Published: July 8, 2024

Language: Английский

Citations

0
Assessment of the potential toxic of naringenin nanoparticles using ex vivo and in silico models DOI Creative Commons
Gaetano Bruno Costa,

Bruna Franzon Rossi,

Byanca Pereira Moreira de Oliveira

et al.

Brazilian Journal of Biology, Journal Year: 2024, Volume and Issue: 84

Published: Jan. 1, 2024

Abstract Naringenin is a flavonoid known for its anti-inflammatory, antineoplastic, antiatherogenic, and antioxidant properties. However, it has poor technological characteristics limited bioavailability, which hinder use in food applications. Nanoencapsulation could address these limitations, but safety concerns regarding nanoengineered bioactives need to be resolved before they can effectively utilized as additives. The objective of this study was evaluate the potential cytotoxic, genotoxic, mutagenic effects both free encapsulated naringenin through vivo experiments using Allium cepa L. roots, along with pharmacokinetic molecular docking analyses. results showed that nanoparticles did not produce significant changes cell division index meristematic cells A. roots. Additionally, no alterations mitotic spindle or chromosomal breaks were observed. Molecular studies indicated binds active site catalase enzyme (CAT) competitive manner, while attaches away from superoxide dismutase (SOD2), demonstrating non-competitive interaction. ADMET property assessments suggested exhibits relatively low toxicity favorable oral administration. In summary, supports naringenin, particularly nanoencapsulated form, safe effective ingredient functional foods, provided nanoencapsulation are adequately addressed.

Language: Английский

Citations

0